Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST), alanine aminotransferase (ALT) =< grade 1Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 10 x ULNXx_NEWLINE_xXPatients must have aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 5 x IULN, unless due to lymphoma, within 42 days prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 times the institutional ULN (unless elevated secondary to lymphomatous involvement of the liver, in which case the AST/ALT must be =< 5 times the institutional ULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3.0 x ULNXx_NEWLINE_xXObtained =< 7 days prior to registration: Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 3 x institutional ULNXx_NEWLINE_xXSerum alanine aminotransferase (ALT), aspartate aminotransferase (AST) > 2.5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x the institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x institutional ULN within 14 days prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases)Xx_NEWLINE_xXSerum alanine aminotransferase (ALT) < 2.5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN, within 2 weeks of the first dose of study treatmentXx_NEWLINE_xXAspartate aminotransferase level (AST) =< 3 x ULN, within 30 days prior to enrollmentXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than or equal to 3 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULNXx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3 x ULN within 14 days prior to study registrationXx_NEWLINE_xXAspartate aminotransferase (AST) =< 3 x ULN within 14 days prior to study registrationXx_NEWLINE_xXEither alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN within 28 days prior to sub-study registration (if both ALT and AST are done, both must be =< 2 IULN); for patients with liver metastases, either ALT or AST must be =< 5 x IULN (if both ALT and AST are done, both must be =< 5 x IULN)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 1.5 x institutional ULN, within 21 days prior to registrationXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULNXx_NEWLINE_xXObtained within 28 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or =< 5 x IULN for patients with known liver metastases)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases)Xx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 2.5 x ULN (values post biliary stenting allowed for eligibility)Xx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 2.5 x IULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULNXx_NEWLINE_xXWithin 14 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN; patients with liver metastases may have AST and ALT of =< 5.0 x IULNXx_NEWLINE_xXCLINICAL/LABORATORY CRITERIA: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or =< 5 x IULN for patients with known liver metastases); these results must be obtained within 28 days prior to registrationXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULN, within 14 days prior to registrationXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x ULN, within 4 weeks of randomizationXx_NEWLINE_xXObtained within 28 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or < 5 x IULN for patients with known liver metastases)Xx_NEWLINE_xXAlanine aminotransferase (ALT) =< 3.0 X ULNXx_NEWLINE_xXWithin 28 days prior to registration: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 3 x IULNXx_NEWLINE_xXWithin 14 days prior to registration: Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN (AST and/or ALT =< 5 x ULN for patients with liver involvement)Xx_NEWLINE_xXAspartate aminotransferase (AST) or alanine aminotransferase (ALT) =< 2 x IULNXx_NEWLINE_xXWithin less than or equal to 14 days prior to registration: Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) both < 2.5 x IULN within 28 days prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULNXx_NEWLINE_xXTransaminases (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) < 6 x institutional ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (=< 5 x IULN secondary to lymphoma) within 28 days prior to registrationXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) both =< 5 x IULN within 28 days prior to registrationXx_NEWLINE_xXAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 3 x ULNXx_NEWLINE_xXAspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x institutional ULN within 30 days of day 1 of studyXx_NEWLINE_xX