Known central nervous system (CNS) metastases or seizure disorder; patients with known brain metastases that have been successfully treated and stable for >= 6 months without requirement for corticosteroids and without seizure activity will be eligibleXx_NEWLINE_xXActive seizure or history of seizure disorderXx_NEWLINE_xXPatients with prior seizure history who have experienced a seizure within the three months prior to enrollment are excludedXx_NEWLINE_xXPatients with active seizure or history of seizure are not eligibleXx_NEWLINE_xXPatients with seizure disorder may be enrolled if well controlledXx_NEWLINE_xXPatients with active seizure or a history of seizure are not eligibleXx_NEWLINE_xXHistory of intractable epilepsy, or uncontrolled seizure disorderXx_NEWLINE_xXSTEP I: Patients must not have active, uncontrolled seizure disorder; patients must have had no seizures in the last 6 monthsXx_NEWLINE_xXPatients receiving glucocorticoids and/or anti-seizure medications are eligible for this studyXx_NEWLINE_xXPatients with a history of encephalitis, multiple sclerosis, or seizures within the last year (from seizure disorder or brain metastasis) should be excluded from this clinical trialXx_NEWLINE_xXComorbid conditions: patients are unable to participate due to the following:* Generalized or partial seizure disorder that is uncontrolled at the time of registration; the definition of controlled generalized seizures is patients must be on a stable dose of anti-seizure medication and without generalized seizures for at least 10 days prior to registration; the definition of controlled partial seizures is patients must be on a stable dose of anti-seizure medication for at least 10 days prior to registration; patients with occasional breakthrough partial seizures are allowed at treating physician�s discretion* Grade 3 or 4 thromboembolic disease within 6 months (mo) of registration* Known history of prolonged QT syndromeXx_NEWLINE_xXPatients with uncontrolled seizure disorder are not eligible; (patients with seizure disorders that do not require antiepileptic drugs, or are well controlled with stable doses of antiepileptic drugs remain eligible)Xx_NEWLINE_xXPatients considered at poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection; examples include, but are not limited to, uncontrolled ventricular arrhythmia, recent (within 3 months) myocardial infarction, uncontrolled major seizure disorder, extensive bilateral lung disease on high resolution computed tomography scan or any psychiatric disorder that prohibits obtaining informed consentXx_NEWLINE_xXUncontrolled seizure disorderXx_NEWLINE_xXIntractable seizures while on adequate anticonvulsant therapy�more than 1 seizure per month for the past 2 monthsXx_NEWLINE_xXPatient has no known history of seizure disorderXx_NEWLINE_xXPatients with a history of uncontrolled seizure disorder; including focal or generalized seizure may not have had a seizure within one year prior to registrationXx_NEWLINE_xXPatients with a high risk of seizures should be excluded from the protocol (e.g. those patients with an uncontrolled seizure disorder, and/or patients who have had a focal or generalized seizure within the last 12 months)Xx_NEWLINE_xXPatients must not have active seizure or history of seizureXx_NEWLINE_xXActive seizure disorder uncontrolled by medicationXx_NEWLINE_xXPatients with seizure disorder requiring medicationXx_NEWLINE_xXPatients with a seizure history will not be permitted on protocol; patients on anticonvulsant medications will not be permitted on studyXx_NEWLINE_xXPatients with active seizures or a history of uncontrolled seizure disorder, including focal or generalized seizure within the past yearXx_NEWLINE_xX