Current use of a prohibited medication; patients receiving any medications or substances that are strong inhibitors or inducers of cytochrome P450, family 3, subfamily A (CYP3A) or cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8) are ineligible; current use of, or intended ongoing treatment with: herbal remedies (e.g., St. John�s wort), or strong inhibitors or inducers of P-glycoprotein (Pgp) or breast cancer resistance protein 1 (Bcrp1) should also be excluded; it is important to regularly consult a frequently-updated list of these agents; as part of the enrollment/informed consent procedures, the patient will be counseled on the risk of interactions with other agents, and what to do if new medications need to be prescribed or if the patient is considering a new over-the-counter medicine or herbal product* Prohibited: strong inducers of CYP3A or CYP2C8** Antibiotics: rifamycin class agents (e.g., rifampin, rifabutin, rifapentine)** Anticonvulsant: carbamazepine, oxcarbazepine phenobarbital, phenytoin, s-mephenytoin** Miscellaneous: bosentan, St. John�s wort* Prohibited: strong inhibitors of CYP3A or CYP2C8** Antibiotics: clarithromycin, telithromycin, troleandomycin** Antidepressant: nefazodone** Antifungals: itraconazole, ketoconazole, posaconazole, voriconazole** Hyperlipidemia: gemfibrozil** Antiretroviral: ritonavir, saquinavir, atazanavir** Miscellaneous: conivaptanXx_NEWLINE_xXPatients receiving any medications or substances that are strong inhibitors or inducers of CYP3A or CYP2C8 are ineligible; current use of, or intended ongoing treatment with: herbal remedies (e.g., St. John�s wort), or strong inhibitors or inducers of permeability-glycoprotein (Pgp) or breast cancer resistance protein 1 (Bcrp1) should also be excluded; below are a few examples of the agents:* Strong inducers of CYP3A or CYP2C8:** Antibiotics: rifamycin class agents (e.g., rifampin, rifabutin, rifapentine)** Anticonvulsants: carbamazepine, oxcarbazepine, phenobarbital, phenytoin, s-mephenytoin** Miscellaneous: bosentan, St. John's wort* Strong inhibitors of CYP3A or CYP2C8** Antibiotics: clarithromycin, telithromycin, troleandomycin** Antidepressants: nefazodone** Antifungals: itraconazole, ketoconazole, posaconazole, voriconazole** Hyperlipidemia: gemfibrozil** Antiretroviral: ritonavir, saquinavir, atazanavir** Miscellaneous: conivaptanXx_NEWLINE_xX