STEP I: Bilirubin =< 1.5 mg/dL (obtained within 28 days prior to randomization)Xx_NEWLINE_xXSTEP II: Any adverse event related to step 1 therapy must have resolved to grade 2 or lessXx_NEWLINE_xXSTEP II: Hemoglobin >= 8 g/dL (within 28 days prior to randomization to Step II)Xx_NEWLINE_xXSTEP II: Platelet count >= 75,000 cells/mm^3 (within 28 days prior to randomization to Step II)Xx_NEWLINE_xXSTEP II: Absolute neutrophil count >= 1000 cells/mm^3 (within 28 days prior to randomization to Step II)Xx_NEWLINE_xXSTEP II: Calculated creatinine clearance >= 30 mL/min (within 28 days prior to randomization to Step II)Xx_NEWLINE_xXSTEP II: Bilirubin =< 1.5 mg/dL (within 28 days prior to randomization to Step II)Xx_NEWLINE_xXSTEP II: SGPT (ALT) and SGOT (AST) < 2.5 times the upper limit of normal (within 28 days prior to randomization to Step II)Xx_NEWLINE_xXSTEP 2: RANDOMIZATIONXx_NEWLINE_xXRANDOMIZATION (STEP 1)Xx_NEWLINE_xXPRIOR TO STEP ONE RANDOMIZATION:Xx_NEWLINE_xXPRIOR TO STEP TWO RANDOMIZATION:Xx_NEWLINE_xX