Patients with prior anthracycline therapy will be excludedXx_NEWLINE_xXPatients must not have received previous systemic anthracycline (intravesical anthracycline is allowed)Xx_NEWLINE_xXPatients must have no prior radiation therapy to >= 25% of the bone marrow for prior systemic anthracycline therapy; prior intravesical anthracycline therapy for non-muscle invasive urothelial carcinoma of the bladder is permittedXx_NEWLINE_xX