Patients must have a Karnofsky performance level of >= 30 for patients > 16 years of age or a Lansky performance scale of >= 30 for patients =< 16 years of age and life expectancy > 8 weeks
400.0
Off treatment > 14 years
143.0
Chemotherapy within 5 years prior to registration; (hormonal therapy is allowable if the disease free interval is >= 5 years)
1120.0
Karnofsky performance scale (KPS for > 16 years [yrs.] of age) or Lansky performance score (LPS for =< 16 years of age) >= 60 assessed within two weeks prior to registration
180.0
Patients must be post-menopausal; post-menopausal will be defined as women meeting any of the following criteria:* >= 60 years of age; or* < 60 years of age and amenorrheic for >= 12 months prior to day 1 if uterus/ovaries are intact; or* < 60 years of age, and the last menstrual period 6-12 months prior to day 1, if intact uterus/ovaries and meets biochemical criteria for menopause (follicle-stimulating hormone [FSH] and estradiol within institutional standard for postmenopausal status); or* < 60 years of age, without a uterus, and meets biochemical criteria for menopause (FSH and estradiol within institutional standards for postmenopausal status); or* < 60 years of age and history of bilateral oophorectomy; surgery must have been completed at least 4 weeks prior to day 1; or* Prior radiation castration with amenorrhea for at least 6 months
1000.0
Karnofsky performance status >= 50 for patients >= 12 years of age; for children < 12 years of age, the Lansky play scale >= 50% can be substituted
75.0
Age > 18 years
140.0
PHASE I: >= 3 years and =< 18 years of age at the time of study enrollment, if able to swallow whole capsules
104.0
Karnofsky performance scale (KPS for >= 16 years [yrs] of age) or Lansky performance score (LPS for < 16 years of age) >= 60 assessed within two weeks prior to registration
52.0
Karnofsky performance scale (KPS for > 16 years of age) or Lansky performance score (LPS for =< 16 years of age) assessed within two weeks of enrollment must be >= 60
40.0
Age >= 18 years
84.0
Age:* Phase 1 (Part A)** Patients must be > than 12 months and =< 21 years of age at the time of study enrollment* Phase 2 (Part B and Part C)** Patients must be > than 12 months and =< 30 years of age at the time of study enrollment
148.0
Parts A & C: patients must be >= 12 months and < 18 years of age at the time of study enrollment
484.0
Parts B1-B6, B8, D1-D6, E3, E4: patients must be >= 12 months and =< 30 years of age at the time of study enrollment
484.0
Part B7: patients must be >= 12 months and < 18 years of age at the time of study enrollment
484.0
Hemoglobin >= 8 g/dL for patients =< 16 years of age; >= 9 g/dL for patients > 16 years of age; Note: no transfusions are permitted 7 days prior to laboratory studies to determine eligibility
340.0
Age >= 14 years (>= 18 years in Germany)
420.0
Patients with body mass index (BMI) < 3rd percentile for age, as defined by WHO criteria for patients 1-2 years of age and Centers for Disease Control and Prevention (CDC) criteria for patients > 2 years of age, are not eligible
81.0
Female patients must have a bone age of equal to or greater than 12 years of age as determined by local read of appropriate radiographic imaging
90.0
Male patients must have a bone age of equal to or greater than 14 years of age as determined by local read of appropriate radiographic imaging
90.0
Cohort 1 patients must have measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1* Note: patients in Cohort 1 will be stratified as follows:** Stratum 1: Patients >= 11 years of age but < 18 years** Stratum 2: Patients >= 11 years of age but < 50 years
90.0
Efficacy Phase: Patients must be =< 40 years of age at the time of enrollment
337.0
Patient must have had a cancer diagnosis < 22 years of age, irrespective of current age
250.0
Patient must have completed cancer treatment >= 2 years prior to study enrollment
250.0
Patients must be >= 18 years of age
969.0
Infants must be > 36 weeks gestational age at the time of enrollment
116.0
Age >= 6 years at the NCI clinical center (>= 18 years at other participating sites)
35.0
Standard risk 1: Patient must be < 11 years of age at enrollment
1680.0
Standard risk 2: Patients must be >= 11 and < 25 years of age at enrollment
1680.0
>= 11 and < 25 years old at enrollment
1680.0