Known central nervous system (CNS) metastases or seizure disorder; patients with known brain metastases that have been successfully treated and stable for >= 6 months without requirement for corticosteroids and without seizure activity will be eligible
102.0
Active seizure or history of seizure disorder
276.0
Patients with prior seizure history who have experienced a seizure within the three months prior to enrollment are excluded
130.0
Patients with active seizure or history of seizure are not eligible
107.0
Patients with seizure disorder may be enrolled if well controlled
275.0
Patients with active seizure or a history of seizure are not eligible
110.0
History of intractable epilepsy, or uncontrolled seizure disorder
330.0
STEP I: Patients must not have active, uncontrolled seizure disorder; patients must have had no seizures in the last 6 months
1080.0
Patients receiving glucocorticoids and/or anti-seizure medications are eligible for this study
75.0
Patients with a history of encephalitis, multiple sclerosis, or seizures within the last year (from seizure disorder or brain metastasis) should be excluded from this clinical trial
54.0
Comorbid conditions: patients are unable to participate due to the following:* Generalized or partial seizure disorder that is uncontrolled at the time of registration; the definition of controlled generalized seizures is patients must be on a stable dose of anti-seizure medication and without generalized seizures for at least 10 days prior to registration; the definition of controlled partial seizures is patients must be on a stable dose of anti-seizure medication for at least 10 days prior to registration; patients with occasional breakthrough partial seizures are allowed at treating physician�s discretion* Grade 3 or 4 thromboembolic disease within 6 months (mo) of registration* Known history of prolonged QT syndrome
440.0
Patients with uncontrolled seizure disorder are not eligible; (patients with seizure disorders that do not require antiepileptic drugs, or are well controlled with stable doses of antiepileptic drugs remain eligible)
598.0
Patients considered at poor medical risk due to a serious, uncontrolled medical disorder, non-malignant systemic disease or active, uncontrolled infection; examples include, but are not limited to, uncontrolled ventricular arrhythmia, recent (within 3 months) myocardial infarction, uncontrolled major seizure disorder, extensive bilateral lung disease on high resolution computed tomography scan or any psychiatric disorder that prohibits obtaining informed consent
1500.0
Uncontrolled seizure disorder
1400.0
Intractable seizures while on adequate anticonvulsant therapy�more than 1 seizure per month for the past 2 months
510.0
Patient has no known history of seizure disorder
44.0
Patients with a history of uncontrolled seizure disorder; including focal or generalized seizure may not have had a seizure within one year prior to registration
333.0
Patients with a high risk of seizures should be excluded from the protocol (e.g. those patients with an uncontrolled seizure disorder, and/or patients who have had a focal or generalized seizure within the last 12 months)
48.0
Patients must not have active seizure or history of seizure
143.0
Active seizure disorder uncontrolled by medication
348.0
Patients with seizure disorder requiring medication
84.0
Patients with a seizure history will not be permitted on protocol; patients on anticonvulsant medications will not be permitted on study
60.0
Patients with active seizures or a history of uncontrolled seizure disorder, including focal or generalized seizure within the past year
72.0