Cluster 0: patients prior study eligible disease patient history treatment days registration Cluster 1: zubrod performance status patients registration days prior criteria step study Cluster 2: interstitial lung pneumonitis disease history pulmonary patients detection known symptomatic Cluster 3: monitoring comply safety opinion investigator able requirements eligible study patients Cluster 4: physical examination history registration days complete prior prestudy obtained patients Cluster 5: autoimmune disease systemic syndrome replacement history patients sclerosis treatment arthritis Cluster 6: composition compounds similar attributed chemical allergic reactions biologic used agents Cluster 7: compounds composition chemical similar attributed allergic reactions biologic history mln Cluster 8: olaparib chemical composition compounds attributed reactions similar allergic biologic cediranib Cluster 9: mother breastfeeding discontinued treated pregnant excluded women study vx mln Cluster 10: pregnant breastfeeding women excluded study discontinued treatment drug dose refrain Cluster 11: olaparib mother breastfeeding discontinued cediranib treated pregnant excluded women study Cluster 12: solid marrow tumors bone involvement known peripheral count anc patients Cluster 13: transplantation organ solid received allogeneic prior eligible patients marrow bone Cluster 14: marrow bone peripheral blood blasts biopsy aspirate patients performed involvement Cluster 15: standard survival prolong therapy progressed histologically tumors solid shown exist Cluster 16: tumors verification patients original elevations relapse fetoprotein beta hcg intrinsic Cluster 17: consent informed signed sign dated form written patient institutional guidelines Cluster 18: informed federal nature accordance guidelines sign written consent investigational institutional Cluster 19: guardians legal parents sign written informed consent patients assent according Cluster 20: representatives assent parents legally authorized according appropriate guidelines sign written Cluster 21: permitting authorization release personal information health signed approved informed consent Cluster 22: hcv hepatitis hbv virus infection cleared known chronic patients eligible Cluster 23: hepatitis antibody positive antigen hcv surface virus negative hbsag core Cluster 24: hepatitis known infection active virus chronic hiv viral patients immunodeficiency Cluster 25: transaminase aminotransferase uln serum ast glutamic alt liver sgot sgpt Cluster 26: transaminase aminotransferase serum sgpt glutamic sgot glutamate pyruvate oxaloacetic alt Cluster 27: sgpt alt uln purpose alanine transaminase glutamate pyruvate aminotransferase serum Cluster 28: transaminase serum aminotransferase sgot glutamic oxaloacetic ast uln aspartate sgpt Cluster 29: score lansky years karnofsky performance age patients status paralysis ambulatory Cluster 30: karnofsky performance status days step registration prior score sequencing ecog Cluster 31: help occasional care karnofsky able performance status patient patients kps Cluster 32: age years score walk wheelchair ambulatory assessing performance lansky patients Cluster 33: years age lansky performance ecog karnofsky scores cooperative eastern corresponding Cluster 34: years age enrollment patients time performance scale months lansky study Cluster 35: acquisition muga ejection fraction echocardiogram left gated ventricular multi scan Cluster 36: fraction echocardiogram shortening ejection radionuclide angiogram gated cardiac echo study Cluster 37: left fraction ejection ventricular lvef normal institutional function indicated heart Cluster 38: lln echo lower left echocardiogram ejection ventricular fraction institutional limit Cluster 39: understand document willingness ability written sign informed consent able guardian Cluster 40: provide informed consent written able willing ability inability patients unable Cluster 41: lar representative legally authorized understand document willingness ability sign written Cluster 42: limits normal institutional creatinine upper bilirubin days uln registration serum Cluster 43: iuln bilirubin total upper registration institutional limit normal days prior Cluster 44: bilirubin upper normal limit total uln institutional times days prior Cluster 45: conjugated sum unconjugated age bilirubin uln upper limit normal subprotocols Cluster 46: limits bilirubin normal total institutional uln upper gilberts direct registration Cluster 47: creatinine uln serum institutional times obtained grade prior days randomization Cluster 48: lln calcium serum magnesium potassium lower phosphorus limit normal delaying Cluster 49: age bilirubin total upper uln limit normal direct times institution Cluster 50: bilirubin uln total gilbert serum known level upper normal enrolled Cluster 51: bilirubin gilberts uln total normal upper syndrome limit institutional unless Cluster 52: gilbert bilirubin total uln syndrome upper limit normal exception institutional Cluster 53: bilirubin total upper institutional normal limit direct range sequencing allowed Cluster 54: vessels invading encasing major blood tumor subject contact indicate participant Cluster 55: endotracheal endobronchial tumor evidence invading tract gi esophagus anus rectum Cluster 56: cavitating radiographic pulmonary lesion evidence subject participant extended extensive extent Cluster 57: institutions identity process ensure board approval order open date entered Cluster 58: identity process ensure board approval order open entered date institution Cluster 59: weeks entering recovered adverse events earlier administered nitrosoureas mitomycin agents Cluster 60: radiotherapy weeks prior chemotherapy patients therapy entering study mitomycin nitrosoureas Cluster 61: grade alopecia toxicities recovered prior related adverse toxicity therapy patients Cluster 62: aminotransferase alt ast alanine aspartate uln iuln institutional days registration Cluster 63: aminotransferase aspartate ast alanine upper alt normal limit uln institutional Cluster 64: ast uln alt performed aminotransferase instead registration value lab practice Cluster 65: upper limit normal creatinine uln institutional ast serum prothrombin alt Cluster 66: corticosteroids decreasing stable corticosteroid dose receiving days prior mri patients Cluster 67: corticosteroid dose modify corticosteroids days elapsed immune decreasing stable related Cluster 68: nodal lesions mm measured measurable axis short longest recorded accurately Cluster 69: measurable neuroblastoma lesions disease detected fluid mibg bone collections gallium Cluster 70: dimension mm ct diameter lesion spiral longest recorded measurable accurately Cluster 71: childbearing pregnancy test potential negative women serum registration days prior Cluster 72: bearing pregnancy test child negative females potential urine serum prior Cluster 73: female pregnancy childbearing potential pregnant test negative patients result urine Cluster 74: nursing childbearing pregnancy test pregnant negative women potential required registration Cluster 75: nursing pregnant women mothers patients excluded unwilling pregnancy step birth Cluster 76: platelets mcl platelet transfusion transfusions requiring plt weeks equal cells Cluster 77: platelet independent transfusion transfusions mm count enrollment defined receiving involvement Cluster 78: ul platelet count transfusion cells independent cd unsupported platelets days Cluster 79: ul platelets mcl untransfused unsupported cells sequencing biopsy treatment tumor Cluster 80: monoclonal hypersensitivity antibody reaction severe history ineligible grade exclusion stratum Cluster 81: dmso immediate chemically dimethyl sulfoxide excipients idiosyncrasy delayed trametinib hypersensitivity Cluster 82: humanized anaphylactic proteins chimeric antibodies fusion allergic reactions severe hypersensitivity Cluster 83: immunotherapies activating conjugates brentuximab prior vedotin restrictions checkpoint purposes monoclonal Cluster 84: myelodysplastic mds aml leukemia myeloid syndrome acute suggestive features smear Cluster 85: syndrome fanconi anemia bloom telangiectasia shwachman kostmann ataxia known genetic Cluster 86: transfusions hematologic evaluable toxicity provided red known platelet meet refractory Cluster 87: chinese hamster ovary recombinant products hypersensitivity antibodies cell human known Cluster 88: syndrome patients gilberts known excluded trisomy necrolysis stevens history epidermal Cluster 89: protein urine urinalysis hour mg dipstick proteinuria screened obtained electrophoresis Cluster 90: protein urine ratio upc creatinine upcr proteinuria hour dipstick collection Cluster 91: expectancy life greater months weeks appropriate patient estimated sequencing equal Cluster 92: expectancy life weeks patients estimated participants physician years procurement year Cluster 93: pregnant partner participating inform suspect immediately woman physician treating study Cluster 94: chemotherapy randomization surgery adjuvant administered days breast neoadjuvant cancer interval Cluster 95: cancer breast invasive situ skin years malignancy carcinoma non melanoma Cluster 96: malignancy melanotic cancer specific cervix situ skin carcinoma exceptions prior Cluster 97: received prior patients treatment days therapy study chemotherapy dose previously Cluster 98: inhibitor parp mek prior treatment kinase braf patients received therapy Cluster 99: rankl denosumab atezolizumab discontinue treatment inhibitor requiring patients kappa require Cluster 100: hsp inhibitor prior therapy received treatment patients zubrod expiratory experiences Cluster 101: abdominal abscess intra perforation gastrointestinal fistula months obstruction history diverticulitis Cluster 102: fistula gastrointestinal perforation history abdominal months repaired postoperative starting surgically Cluster 103: qtc prolong drugs alternatives interval receiving pointes torsades cause alternative Cluster 104: qt qtc interval milliseconds corrected torsades pointes prolongation long congenital Cluster 105: qt syndrome long congenital qtc family history ecg corrected msec Cluster 106: qt interval qtc corrected msec qtcf fridericia formula electrocardiogram ms Cluster 107: cardiac heart york association iii resulting activity iv new physical Cluster 108: heart myocardial infarction failure months congestive angina history york association Cluster 109: stage iv iii disease patients cancer ii carcinoma ovarian diagnosis Cluster 110: time measurements obtain prothrombin ptt thromboplastin pt normalized inr neurologic Cluster 111: thromboplastin partial time aptt ptt activated uln normal upper limit Cluster 112: inr normalized international ratio time thromboplastin prothrombin ptt partial uln Cluster 113: pt anticoagulant ptt time thromboplastin anticoagulants intended therapeutic range partial Cluster 114: hodgkin expansion lymphoma cohort participants enrollment weeks prior dl serum Cluster 115: albumin dl serum days registration patients prior hypersensitivity mg inclusion Cluster 116: phosphatase alkaline uln involvement iuln days liver prior registration bone Cluster 117: creatinine mg dl serum registration iuln days prior umol level Cluster 118: area surface body bsa enrollment patients time study mg level Cluster 119: bilirubin mg dl total direct serum gilbert patient syndrome registration Cluster 120: requiring hypothyroidism autoimmune mellitus recur trigger psoriasis diabetes expected vitiligo Cluster 121: glucose fasting mg dl blood diabetes serum mellitus age random Cluster 122: bun urea nitrogen blood mg dl chloride bicarbonate glucose phosphatase Cluster 123: transplant stem cell allogeneic autologous prior graft host patients transplantation Cluster 124: tacrolimus cyclosporine transplant prevent host post versus graft marrow trial Cluster 125: creatinine clearance gault min formula cockcroft ml calculated hour serum Cluster 126: creatinine clearance min ml calculated serum measured uln crcl obtained Cluster 127: creatinine institutional normal levels clearance min ml upper limit patients Cluster 128: calc creatinine calculated min clearance ml uln upper mg normal Cluster 129: gfr glomerular filtration rate min ml creatinine radioisotope clearance estimated Cluster 130: creatinine gault cockcroft clearance min ml equation using calculated formula Cluster 131: gp inhibitors glycoprotein inducers bcrp strong binding member cypa adenosine Cluster 132: cytochrome subfamily cypa family polypeptide strong inhibitors inducers cypc medications Cluster 133: strong cypc miscellaneous inducers cypa inhibitors wort st antibiotics agents Cluster 134: cypa inducers strong inhibitors medications drugs use substances concomitant moderate Cluster 135: cypc strong inducers inhibitors cyp cytochrome week preceding cypa alternative Cluster 136: inhibitors azacitidine decitabine deacetylase histone hydroxyurea interferon tyrosine hematopoietic thalidomide Cluster 137: swallow able pills absorb medication patients inability drug explained experiencing Cluster 138: oral swallow medications ability medication retain able absorption gastrointestinal unable Cluster 139: retain stomach malabsorption bowels alter medication abnormalities swallow absorption major Cluster 140: bowel gastrointestinal vomiting absorption nausea resection disease significantly inflammatory diseases Cluster 141: fast mln maintain oral hour hours medication administration required bowel Cluster 142: obstruction bowel signs symptoms starting drugs history month current study Cluster 143: state curative survival quality therapy prolong current proven life acceptable Cluster 144: oximetry pulse dyspnea rest air room exercise evidence intolerance breathing Cluster 145: rvo retinal occlusion vein history evidence current risk csr intraocular Cluster 146: dependency tpn hydration nutrition parenteral iv total intravenous current participants Cluster 147: history coronary heart evidence cardiac controlled mmhg current defined subjects Cluster 148: overlap fields radiation result pelvis therapy neck head irradiation previous Cluster 149: overlap fields region result radiotherapy radiation cancer therapy prior study Cluster 150: dipg stratum progressed progressive recurrent non patients irradiation refractory enrollment Cluster 151: eiaed epileptic drugs inducing anti enzyme taking patients previously enrolled Cluster 152: aallb aall apecb open enrolled enrollment patients classification project sample Cluster 153: anticonvulsants seizure inducing enzyme disorder controlled enrolled seizures patients non Cluster 154: seizure disorder uncontrolled history patients seizures active generalized months medication Cluster 155: metastatic disease locally advanced patients evidence unresectable prior cancer definitive Cluster 156: histologically confirmed cytologically cancer diagnosis metastatic patients proven unresectable cell Cluster 157: ain anal stain intraepithelial neoplasia hsil proven biopsy cyclin junction Cluster 158: higher neuropathy grade peripheral terminology common ctcae events adverse step Cluster 159: sensory motor neuropathy grade ctcae peripheral terminology common equal events Cluster 160: neuropathy grade peripheral greater patients severity exceeds registration sensory permitted Cluster 161: myelosuppressive days dose enrollment prior chemotherapy agent immunomodulatory elapsed nitrosourea Cluster 162: days events adverse infusion growth known agent elapsed occurring extended Cluster 163: myelosuppressive weeks nitrosourea anticancer received chemotherapy study prior dose known Cluster 164: step registration prior weeks mcl induction screening treatment optional pre Cluster 165: pre criteria registration eligibility inclusion step experiences experiencing experimental expert Cluster 166: eligibility criteria step randomization registration induction meet preregistration screening operative Cluster 167: neutrophil absolute count mm microliters cells randomization enrollment weeks days Cluster 168: platelet count mm days registration randomization prior mcl obtained ml Cluster 169: absolute neutrophil mcl count growth hematopoietic factors days prior ul Cluster 170: leukocytes mcl mm ul lower registration equal days initiation obtained Cluster 171: granulocytes ul anc cells mcl absolute extending explained experiencing experimental Cluster 172: peripheral anc neutrophil absolute mm count zubrod exposed experimental expert Cluster 173: absolute neutrophil count ul anc peripheral unsupported cells lymphocyte weeks Cluster 174: anc neutrophil absolute count mcl registration days prior obtained equal Cluster 175: white wbc blood ul count cell cells randomization prior obtained Cluster 176: anc neutrophil absolute mm count cells days registration prior obtained Cluster 177: cells platelets mm days prior registration obtained entry study experiencing Cluster 178: brain metastases treated patients stable prior treatment mri imaging untreated Cluster 179: corticosteroids brain anticonvulsants inducing enzyme subjects weeks stable metastases month Cluster 180: alchemist screen alliance registered trial randomization prior patients express expressing Cluster 181: cns nervous central metastases involvement patients disease brain lumbar puncture Cluster 182: brain metastases carcinomatous meningitis remained stable trial patients clinical metastatic Cluster 183: brain metastases trial excluded clinical known patients participants described trials Cluster 184: contraceptive measures reproductive pregnancy effective bilateral potential use time celibacy Cluster 185: study agree contraception use male pregnant potential dose effective method Cluster 186: accepted males abstain sexually intercourse effective advised sexual contraception strongly Cluster 187: females method agreed males contraceptive reproductive effective participate unless menarchal Cluster 188: reproductive contraceptive sexually effective method agreed duration potential use participation Cluster 189: infection exhibiting bacterial fungal signs despite improvement antibiotics symptoms appropriate Cluster 190: signs symptoms cycle infection day weeks prior tuberculosis clinical active Cluster 191: infection active requiring systemic antibiotics severe patients therapy fungal septicemia Cluster 192: cancer adequately treated surveillance cell program patient localized followed cervical Cluster 193: carcinoma cell squamous skin basal situ malignancies treated malignancy years Cluster 194: cancer adequately treated cell basal patient squamous free situ skin Cluster 195: cancers skin patient thyroid advanced known active basal screening squamous Cluster 196: laboratory clia certified mutation braf improvement clinical amendments approved mutations Cluster 197: choice apecsc actionable match assignment given molecular analysis mutation presence Cluster 198: egfr exon tki tm mutation generation erlotinib deletion treatment testing Cluster 199: return enrolling institution follow willing alliance willingness monitoring active phase Cluster 200: permit circumstances follow completion required study travel issue instance patients Cluster 201: permits psychological general follow health ability completion requirements required study Cluster 202: sequencing antiretroviral combination immunodeficiency ineligible hiv biopsy virus human positive Cluster 203: immunodeficiency hiv virus human known positive infection patients excluded individuals Cluster 204: antiretroviral combination hiv ineligible immunodeficiency positive human virus therapy patients Cluster 205: hiv licensed assay record approved documentation test rapid western blot Cluster 206: immunocompromised hiv positive immunodeficiency virus human known corticosteroids related patients Cluster 207: hiv retroviral positive opportunistic virus haart immunodeficiency human cd regimen Cluster 208: hiv cd immunodeficiency cluster differentiation positive virus human antiretroviral count Cluster 209: medications systemic adrenocortical anti tnf mineralocorticoids azathioprine orthostatic fludrocortisone dose Cluster 210: anthracycline intravesical therapy prior excluded systemic patients muscle previous urothelial Cluster 211: chemotherapy cancer different allowable prior systemic note study egf current Cluster 212: radiation therapy prior chemotherapy received weeks patients pelvic elapsed treatment Cluster 213: edition ajcc committee joint th american cancer stage staging nsclc Cluster 214: therapy prior chemotherapy cancer systemic patients hormonal treatment anti radiation Cluster 215: registration therapy days prior radiation treatment investigational immunotherapy chemotherapy mitomycin Cluster 216: chemotherapy prior neoadjuvant patients received therapy treatment surgery radiation adjuvant Cluster 217: illness uncontrolled compliance social situations psychiatric intercurrent pectoris requirements arrhythmia Cluster 218: bp mmhg pressure blood antihypertensive diastolic systolic hypertension medications controlled Cluster 219: pressure blood mmhg hypertension systolic diastolic hypertensive uncontrolled controlled hg Cluster 220: triglyceride mg dl level fasting serum applicable mmol gsk nf Cluster 221: cholesterol mg dl level serum fasting mmol total draw gsk Cluster 222: fasting triglycerides mg dl equal cholesterol mmol lowering lipid values Cluster 223: mmol dl normalize mg despite intervention levels calcium hemoglobin adjusted Cluster 224: mg years age dl males creatinine females serum maximum min Cluster 225: mg dl years male female age creatinine gender radioisotope gfr Cluster 226: male female years creatinine age gender follows serum based radioisotope Cluster 227: maximum creatinine mg dl male age serum female years gender Cluster 228: transfusion hemoglobin dl days blood past enrollment prior administration preceding Cluster 229: hemoglobin dl transfused level weeks unsupported hg mg randomization criterion Cluster 230: platelets mm prior weeks days equivalent cell randomization ctcae enrollment Cluster 231: platelets mcl registration days prior obtained equal administration start step Cluster 232: hemoglobin dl hgb achieve intervention transfusion acceptable note use days Cluster 233: transfusions hemoglobin rbc dl red receive blood cell requiring involvement Cluster 234: step randomization ii prior days dl bilirubin mg cells mm Cluster 235: hemoglobin dl days registration prior randomization obtained step transfusions weeks Cluster 236: phase ii arms randomized portion patients criteria registration weeks prior Cluster 237: hbac glycosylated hemoglobin ac hb measurement equal registration days prior Cluster 238: hgb hemoglobin dl obtained transfusions registration days prior allowed procurement Cluster 239: cbc differential obtained blood count registration days complete step prior Cluster 240: corticosteroids steroids systemic prednisone mg inhaled immunosuppressive topical daily doses Cluster 241: complications resolved related infectious medical significant induction consolidation therapy cycle Cluster 242: ischemic revascularization artery event procedures including fibrillation ventricular cerebrovascular attack Cluster 243: significant unrelated organ dysfunction infections hepatic results interfere systemic procedures Cluster 244: fda food nci institute met national studies requirements human administration Cluster 245: adverse events common terminology ctcae grade criteria version alopecia prior Cluster 246: ctcae grade alopecia nci version institute terminology national unresolved common Cluster 247: pd anti prior therapy treatment agents patients ctla antibody progression Cluster 248: anti pd antibody ctla programmed death cell targeting lymphocyte cytotoxic Cluster 249: consent mandatory provide specific study entry informed tissue submission including Cluster 250: specific informed consent provide study registration signed representative prior legally Cluster 251: specific study provide informed consent entry patient prior representative legally Cluster 252: platelets microliters plt dependent study day transfusion dose weeks treatment Cluster 253: months teaspoon dose hemoptysis red treatment study indicative bleeding hemorrhage Cluster 254: half lives whichever dose shorter days investigational minimum preceding study Cluster 255: wound healing fracture ulcer non bone cabozantinib dose surgeries history Cluster 256: live vaccine attenuated influenza vaccines vaccination flu seasonal dose study Cluster 257: ppi pump proton inhibitor receiving dose study concomitant stop using Cluster 258: consecutive female childbearing months mature naturally potential postmenopausal menses bilateral Cluster 259: fathering willing childbearing birth control child potential medically form treated Cluster 260: consecutive undergone childbearing potential months orientation naturally meets sexual ligation Cluster 261: fcbp pregnancy lenalidomide agree effective method childbearing consecutive days commit Cluster 262: capsules swallow able patients tube nasogastric broken crushed inability tablets Cluster 263: uncontrolled infection eligible patients active patient step subprotocols excluded general Cluster 264: intact capsules swallow able patients subprotocol subprotocols assigned general tablets Cluster 265: tablets swallow able unable intact patients subject ability eligible chewed Cluster 266: karnofsky eastern cooperative ecog performance group oncology status kps greater Cluster 267: gog performance gynecologic status group oncology patients grade patient protocol Cluster 268: performance ecog status ps patients step registration score criteria greater Cluster 269: cooperative eastern ecog group oncology performance status ps patients score Cluster 270: recist measurable response criteria solid evaluation disease tumors evaluable defined Cluster 271: measurable disease ct recist patients imaging tomography mri assessed resonance Cluster 272: evaluable measurable disease patients parts radiologically recist ca participants clinically Cluster 273: feeding breast women pregnant females eligible lactating study girls menarchal Cluster 274: allografts organ patients zubrod experimental expert expiratory explained exploratory exposed Cluster 275: sun exposure sunscreen protection excessive anticipated avoid willingness adequate use Cluster 276: lactating breastfeed females plan infants eligible excluded exposure expert expiratory Cluster 277: breastfeed lactating agreed infants unless females eligible female pregnancy potential Cluster 278: study pregnant contraception agree participation adequate duration men women use Cluster 279: forms medically willing sexually acceptable able contraception childbearing women men Cluster 280: bisphosphonate hypercalcemia osteoporosis reasons taking therapy use metastasis symptomatic allowed Cluster 281: prohibited use bisphosphonates herbal concurrent dhea ephedra ginseng dehydroepiandrosterone yohimbe Cluster 282: wocbp women contraception nivolumab potential men postmenopausal childbearing use instructed Cluster 283: women childbearing potential contraception adequate employ unwilling practice male men Cluster 284: major procedure surgical anticipation traumatic injury course days biopsy need Cluster 285: phase study weeks administered levels referred eligibility early recovered prior Cluster 286: major surgery days registration prior delayed immunotherapy toxicity treatment extensive Cluster 287: weeks prior therapy study completed radiation shorter recovered half toxicity Cluster 288: surgery major weeks recovered prior effects patients placement surgical study Cluster 289: investigational receiving agents patients ineligible participants study treatment trials cancer Cluster 290: investigational currently drug receiving eligible patients anticancer therapy ineligible anti Cluster 291: currently agents anti receiving cancer eligible patients anticancer platelet study Cluster 292: receiving agents eligible corticosteroid currently anti corticosteroids investigational cypa drugs Cluster 293: blocks slides tissue notified unavailable sent chair enrollment available study Cluster 294: approaching biospecimens department regarding check release investigators submission pathology site Cluster 295: tissue tumor biopsy available archival submission slides paraffin patients block Cluster 296: investigational agent receiving received treatment days neoplasm type patients dose Cluster 297: investigational agents weeks receive past received planning patients receiving anticancer Cluster 298: cycle day herbal therapy week weeks prior contraceptives anticancer radiotherapy Cluster 299: cycle day investigational agent weeks treatment prior past agents received