Pulmonary function: a. Pulse oximetry with a baseline O2 saturation of ? 85% b. Diffusing capacity of the lung for carbon monoxide (DLCO) > 40% (corrected for hemoglobin) d. Renal function: Serum creatinine ? 1.5 x the upper limit of normal for age as per local laboratory and 24 hour urine creatinine clearance >70 mL/min; or GFR > 70 mL/min/1.73 m2 by radionuclide Glomerular Filtration Rate (GFR). e. Hepatic function:
Patients with pulmonary, cardiac, hepatic or renal impairment that would limit their ability to receive cytoreductive therapy and compromise their survival; this should include patients with any of the following:\r\n* Severe pulmonary dysfunction associated with a carbon monoxide diffusing capacity (DLCO) (corrected for hemoglobin) < 60%, or requires supplemental oxygen\r\n* Uncontrolled malignant arrhythmias, or clinical evidence of congestive heart failure (New York class III-IV) or ejection fraction < 50%\r\n* Renal disease with estimated glomerular filtration rate (GFR) by creatinine clearance or iothalamate clearance < 50 ml/min/1.73 m^2 body surface area\r\n* Serum glutamate pyruvate transaminase (SGPT)/aspartate aminotransferase (AST) > 3 times normal or direct bilirubin greater than 2.5 mg/dL on two repeated tests
Decreased renal function with a GFR of less than 50ml/1.73m2/min.
Adequate renal function as evidenced by serum creatinine ?2.0 × ULN or creatinine clearance 40 mL/min based on the Cockcroft-Gault glomerular filtration rate (GFR)
Within 7-10 days of study drug administration: Renal function\r\n* Adults (age 18 or >): Serum creatinine =< 1.2 mg/dl; if serum creatinine is > 1.2 mg/dL, nuclear glomerular filtration rate (GFR) will be measured\r\n** GFR will need to be >= 80 ml/min/1.73 m^2 for subjects =< 40 years old\r\n** >= 70 ml/min/1.73 m^2 for subjects between 41-50\r\n** >= 60 ml/min/1.73 m^2 for subjects between 51-60\r\n** >= 50 ml/min/1.73 m^2 for subjects > 60 years old\r\n* Children (age < 18): nuclear GFR >= 80 mL/min/1.73 m^2
Inadequate renal function at screening as demonstrated by creatinine clearance < 50 mL/min or glomerular filtration rate < 50 mL/min/1.73 m^2
Adequate renal function with glomerular filtration rate equal to or greater than 30 ml/min/1.73 m2
Adequate renal function defined as normal serum creatinine for the participant's age or creatinine clearance or radioisotope glomerular filtration rate (GFR) 70 milliliter per minute per 1.73 square meter (mL/min/1.73 m^2) at Cycle 1 Day 1 pre-dosing
Patients must have adequate renal/hematologic function, as defined by creatinine clearance > 30ml/min and platelets>50,000.
Adequate renal function defined by a creatinine clearance of ?30 mL/min
Adequate renal function: Estimated glomerular filtration rate ? 30 mL/minute using the Cockroft-Gault formula or: a serum creatinine based on age/gender as outlined in the protocol
Subjects must have adequate kidney function, with serum creatinine < 1.5 x upper limit of normal (ULN) or calculated glomerular filtration rate (GFR) of > 45/mL/min/1.73 m^2
Subjects must have adequate renal function as evidenced by a serum creatinine ?2.0 × ULN or creatinine clearance >40mL/min based on Cockroft-Gault glomerular filtration rate (GFR)
Patient must have adequate renal function as evidenced by: Serum creatinine ?2.0 × ULN or Creatinine clearance >40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimated: (140-Age) x (weight in kg) x (0.85 if female)/72 x serum creatinine
Adequate renal function, defined as serum creatinine ?1.5x ULN or GFR >50 mL/min
Renal function\r\n* >= 70 ml/min/1.73 m^2 for subjects between 41-50\r\n* >= 60 ml/min/1.73 m^2 for subjects between 51-60\r\n* >= 50 ml/min/1.73 m^2 for subjects > 60 years old\r\n** Renal function criteria based on our previous experience with 90Y-DOTATOC therapy and known changes in GFR with age
Adequate renal function defined as glomerular filtration rate ? 40 mL/min,
Subjects must have adequate renal function as evidenced by: a. Serum creatinine ?2.0 × ULN OR b. Creatinine clearance >40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimation: (140 - Age) x (weight in kg) x (0.85 if female)/72 x serum creatinine
Subjects with end stage renal function (creatinine clearance [CrCl] < 15 mL/min or glomerular filtration rate [GFR] <15 mL/min) regardless of whether hemodialysis is required
Subjects must have adequate renal function as evidenced by: • Serum creatinine ?2.0 × ULN OR • Creatinine clearance greater than 40 mL/min based on the Cockroft-Gault glomerular filtration rate (GFR) estimation: (140 - Age) x (weight in kg) x (0.85 if female)/72 x serum creatinine
Creatinine clearance > 60 ml/min/1.73 m^2; glomerular filtration rate (GFR) may also demonstrate adequate renal function
Renal Function: Patients must have serum creatinine ? 1.5 times upper limit of institutional normal for age and/or GFR ? 70 mL/min/1.73 m2.
Adequate renal function [creatinine ? 1.5x ULN (upper limit of normal)] or GFR of ? 60mL/min.
Adequate renal function (creatinine ? 1.5×ULN [upper limit of normal]) or glomerular filtration rate of ? 60 mL/min
Adequate renal function, defined as serum creatinine ?2.0 times ULN and creatinine clearance >50 mL/min or estimated glomerular filtration rate (eGFR) >50 mL/min/1.73 m^2
Adequate renal function (creatinine ? 1.5x upper limit of normal [ULN]) and/or glomerular filtration rate (GFR) of ?50 mL/min.
13. Adequate renal function (creatinine ? 1.5 x ULN [upper limit of normal] or glomerular filtration rate of ? 50mL/min).
Adequate renal function as evidenced by: serum creatinine ?2.0 × ULN; OR creatinine clearance > 40 mL/min based on the Cockroft-Gault GFR estimation: (140 - Age) x (weight in kg) x (0.85 if female)/72 x serum creatinine
Must have adequate organ function as defined by the following values: renal function - 24 hr creatinine clearance (revised Schwartz formula), or radioisotope glomerular filtration rate (GFR) >=60 milliliter (mL) per minute per 1.73 meter square (mL/min/1.73m^2); or a serum creatinine <=upper limit of normal (ULN) for age and gender; liver functions as bilirubin (sum of conjugated + unconjugated) <=1.5 x ULN for age, alanine aminotransferase (ALT) <=2.5 x ULN; for the purposes of enrollment and toxicity monitoring the ULN for ALT will be 45 unit per liter (U/L); cardiac function - corrected QT (QTcB) interval <480 milliseconds (msec), left ventricular ejection fraction (LVEF) >=lower limit of normal (LLN) by ECHO.
Adequate renal and metabolic function defined as: calculated glomerular filtration rate (eGFR) (Schwartz formula), or radioisotope GFR >=90 milliliters/minutes (mL/min)/1.73 meter square (m^2); or a serum creatinine within the institutional reference range upper limit of normal (for age/gender, if available).
Requirement for CD34+ stem cell selection for a second infusion of stem cells following an allogeneic stem cell transplant from a related or unrelated adult donor for the following conditions:\r\n* Primary graft rejection\r\n* Secondary graft rejection\r\n* Poor graft function \r\n* Disease recurrence\r\nNote: pre-infusion conditioning with chemotherapy and/or immunotherapy to be determined by the primary BMT physician and the protocol principal investigator (PI) based on clinical condition of the patient\r\n* Specific Organ System Function Requirements from PBMT 1001\r\n** Myeloablative\r\n*** Cardiac (shortening fraction of > 26% by echo or ejection fraction of > 47%)\r\n*** Renal (creatinine clearance or glomerular filtration rate [GFR] >= 40 ml/min, or > 60 ml/min.1.73 m^2)\r\n*** Pulmonary (DLCO > 50% by pulmonary function test [PFT])\r\n*** Liver (AST/ALT no greater than 3 times the upper limit of normal)\r\n** Reduced Intensity\r\n*** Cardiac (shortening fraction of > 20% by echo or ejection fraction of > 40%)\r\n*** Renal (creatinine clearance or GFR >= 30 ml/min, or > 40 ml/min 1.73 m^2)\r\n*** Pulmonary (DLCO > 40% by PFT)\r\n*** Liver (AST/ALT no greater than 5 times the upper limit of normal)
Patients with inadequate renal function (creatinine >= 1.5 times upper limit of normal) or acute or chronic renal insufficiency (glomerular filtration rate < 20 ml/min)