If liver cirrhosis is present, patient must have a Child-Pugh A or B (7 points) classification.
Child-Pugh score B or C (for cirrhosis patients only)
Cirrhosis with Child-Pugh score > 7
Ongoing chronic alcohol consumption or cirrhosis with Child-Pugh score B or C. Known Gilbert disease.
Cirrhosis of the liver, Child-Pugh Stage B or C, or history of liver transplant,
Subjects with child Pugh B or C cirrhosis; patients with child Pugh A cirrhosis will be excluded from the dose escalation portion of the trial but can be included in the dose expansion portion of the trial with one dose reduction from the established dose
If patient has underlying cirrhosis, only Child-Pugh classification group A patients should be included in this study; clinical assessment of ascites and encephalopathy is required; Child-Pugh classification must be determined for all study participants at the time of eligibility analysis; as albumin and prothrombin time (PT)/international normalized ratio (INR) are required for Child-Pugh classification; these labs should be drawn with other labs required for eligibility analysis
Patients with cirrhosis and severe synthetic liver dysfunction (Child Pugh B-C)
Child Pugh class A (score = 5 or 6) cirrhosis (assessed within 14 days of SBRT)
Liver cirrhosis or chronic liver disease Child-Pugh B or C
Underlying hepatic cirrhosis with Child-Pugh class B9 or C
If liver cirrhosis is present, patient must have a Child-Pugh A/B7 classification
Total bilirubin; if cirrhosis present: part of Child Pugh requirement; if no cirrhosis: bilirubin should be =< 2 x upper limit of normal (ULN)
Serum albumin; if cirrhosis present: part of Child Pugh requirement; if no cirrhosis: albumin should be >= 2.5 g/dl
Patients with a Child-Pugh score less than 6 or greater than 9 for radiation naive patients with cirrhosis (cohort 1)
Child-Pugh score of greater than 6 for patients with cirrhosis who previously received liver directed radiation (EBRT or Y90 RE) (cohort 3)
No evidence of cirrhosis or cirrhosis grade of Child-Pugh class A or B7
Cirrhosis classified as Child-Pugh Class B (Appendix C).
Child-Pugh Class A or C cirrhosis, or hepatic encephalopathy.
Patients with Child-Pugh Class B or C cirrhosis or with evidence of portal hypertension by history, endoscopy, or radiologic studies.
Cirrhosis of any Child Pugh class
Patient with a Child-Pugh score B or C (for cirrhosis patients only)
Child-pugh B or C cirrhosis.
cirrhosis at a level of Child-Pugh B (or worse)
Cirrhosis with Child-Pugh score of B or C
Have a history of or have current hepatic encephalopathy of any grade, or ascites of Grade >1, or cirrhosis with Child-Pugh Stage B or higher.
cirrhosis at a level of Child-Pugh B (or worse) or
Patients with Child Pugh class B or C hepatic cirrhosis
Liver cirrhosis ? Child-Pugh class B with uncontrolled ascites
Cirrhosis grade of Child-Pugh class A; Child-Pugh status should be calculated based on clinical findings and laboratory results during the screening period
If liver cirrhosis is present, patient must have a Child-Pugh A/B7 classification
Total bilirubin\r\n* If cirrhosis present: part of Child Pugh requirement\r\n* If no cirrhosis: bilirubin (bili) should be =< 2 x upper limit of normal (ULN)
Serum albumin\r\n* If cirrhosis present: part of Child Pugh requirement\r\n* If no cirrhosis: albumin should be >= 2.5 g/dl
Non-cirrhotic or no more than Child-Pugh A cirrhosis
No cirrhosis or Child-Pugh A (Child-Turcotte-Pugh [CTP] score < 7) cirrhosis
Child-Pugh B or C cirrhosis (CTP score >= 7)
If cirrhosis, Child-Pugh classification A or B
Patients with cirrhosis classed as Child-Pugh B or C.
Have liver cirrhosis with a Child-Pugh Stage of B or C.
If patient has underlying cirrhosis, only Child-Pugh classification Group A patients may be included in the resectable cohort of this study; for patients with unresectable disease, Child-Pugh classification Groups A and B are allowed; clinical assessment of ascites and encephalopathy is required; Child-Pugh classification must be determined for all study participants at the time of eligibility analysis; note albumin and prothrombin time (PT)/international normalized ratio (INR) are required for Child-Pugh classification; these laboratories (labs) should be drawn with the other labs required for eligibility analysis
Patients with chronic hepatitis and/or cirrhosis are eligible, but must be Child-Pugh class A
If liver cirrhosis is present, patient must have a Child-Pugh A or B (7 points) classification
Have received a liver transplant, or have liver cirrhosis with a Child-Pugh Stage of B or C.
Have hepatocellular cancer, liver cirrhosis with a Child-Pugh stage of B or higher, or have received a liver transplant
cirrhosis at a level of Child-Pugh B (or worse) or
History of cirrhosis of the liver based on the Child-Pugh score of Class B or C are not eligible to participate. (Appendix B.)
Individuals with a clinical diagnosis fibrosis or cirrhosis of the liver (no more than Child-Pugh classification A; Child-Pugh-Turcotte score of 6 or less) who have:\r\n* An indication for surgical liver resection, OR\r\n* A clinical liver biopsy (with research tissue specimens available for analysis) =< 3 months prior to pre-registration
Known cirrhosis diagnosed with Child Pugh class A or higher liver disease
Child Pugh C cirrhosis or other significant comorbid conditions