Patients must have corrected QT (QTc) interval < 500/msec (by Bazett’s formula) on baseline ECG
Corrected QT interval (QTc) < 480 msec
Patients with a baseline QTc of > 450 msec are excluded; Bazett’s formula is to be used for measurement of the corrected QT interval: the QT interval (msec) divided by the square root of the RR interval (msec)
Corrected QT interval, QTc < 480 msec\r\n* Note: Repeat echocardiogram is not required if echocardiogram was obtained within 21 days of study enrollment
Baseline corrected QT interval (QTc) =< 450 msec\r\n* Note: QT interval calculation by the Fridericia formula is permitted
Corrected QT interval (QTc) < 480 msec
Rate-corrected QT interval of electrocardiograph (QTc) > 470 msec on a 12-lead electrocardiography (ECG) during screening
Unstable cardiac dysrhythmias or persistent prolongation of the corrected QT interval (QTc) (Fridericia) to >450 msec for males or >470 msec for females.
Corrected QT interval (QTc) interval greater than 450 msec (males) or greater than 470 msec (females).
Patients must have a corrected QT (QTc) interval of less than 480 msec
Patients must not have a corrected QT interval (QTc) of > 480 msec using Bazett’s formula
Corrected QT (QTc) interval > 470 msec
Corrected QT (QTc) interval < 470 msec
Participants must have a corrected QT (QTc) of =< 470 msec on the screening electrocardiography (EKG)
Corrected QT (QTc) interval > 500 msec, unless a bundle branch block is also present
Corrected QT interval (QTc) =< 480 msec
Consistent corrected QT (QTc) > 450 msec for men and > 470 msec for women by Fridericia formula, on 3 separate electrocardiograms (ECGs)
INCLUSION CRITERIA FOR REGISTRATION (HER2 MUTATION IDENTIFIED BY WASH U GPS LABORATORY): Corrected QT (QTc) interval =< 450 msec for men or =< 470 msec for women within 2 weeks of registration
Patients with corrected QT (QTc) interval of > 450 msec or those on medications known to prolong QTc interval
Ongoing cardiac dysrhythmias of National Cancer Institute (NCI) CTCAE grade >= 2 or prolongation of the corrected QT interval (QTc) interval to > 500 msec
Participants with any history of corrected QT (QTc) prolongation (i.e. QTc interval of > 450 msec)
Mean QT interval ? 470 msec
COHORT 3: ENDOMETRIAL CANCER: Patients with a mean corrected QT (QTc) interval of > 500 msec or receiving therapeutic agents known to prolong the QT interval
Corrected QT (QTc) < 500 msec by Fridericia
Corrected QT interval (QTc) prolongation > 480 msec
Subjects with a corrected QT (QTc) > 480 ms (QTc > 510 msec for subjects with a bundle branch block at baseline
Screening rate-corrected QT interval (QTc) must be <450msec and a resting heart rate of at least 50-90 bpm via a standard 12-lead ECG within 28 days prior to registration.
Subjects with a corrected QT (QTc) > 480 ms (QTc > 510 msec for subjects with a bundle branch block at baseline)
Rate-corrected QT interval of electrocardiograph (QTc) > 470 msec on a 12-lead ECG during screening
Mean resting corrected QT interval (QTc) >470 msec
PART 2 GROUP 1 INCLUSION CRITERIA: Corrected QTc =< 480 msec
PART 2 GROUP 2A INCLUSION CRITERIA: Corrected QTc =< 480 msec
PART 2 GROUP 3 INCLUSION CRITERIA: Corrected QTc =< 480 msec
Corrected QT (QTc) =< 450 msec. for men or QTc =< 470 msec. for women
Mean resting corrected QT interval (QTc) >470 msec, obtained from 3 ECGs, using the screening clinic ECG machine-derived QTc value.
Corrected QT interval (QTc) =< 480 msec
Screening electrocardiography (ECG) with corrected QT (QTc) interval > 480 milliseconds (corrected by Fridericia); in the event that a single QTc is > 480 msec, the subject may enroll if the average QTc for 3 ECGs is < 480 msec
Patients with prolonged corrected QT interval, defined as corrected QT (QTc) > 450 msec
Corrected QT (QTc) interval >= 480 msec (>= 500 msec for subjects with bundle branch block)
Nilotinib\r\n* Normal QTc interval on screening ECG evaluation, defined as < 450 msec for men and < 470 msec for women\r\n* Discontinuation of any medications known to contribute significantly to the risk of QT prolongation at least 48 hours prior to start of study drug; Levaquin and Zofran are an exception; of note, certain agents that prolong the corrected QT interval may be allowed but only after discussion with the chemotherapy pharmacist; should the investigator believe that therapy with a potentially QT prolonging medication is vital to an individual subject’s care, then additional ECGs should be done at the investigator’s discretion to ensure the subject’s safety
Syndrome of congenital corrected QT interval (QTc) prolongation or QTc > 500 msec
Mean resting corrected QT interval (QTc) >450 millisecond (msec), obtained from 3 ECGs recordings, using the screening clinic ECG machine-derived QTc value.
QT interval corrected for heart rate (QTc) (corrected by Fridericia's method) > 450 msec at Screening
QT interval corrected for rate (QTc) > 480 msec for on the ECG obtained at Screening using Fridericia method for QTc calculation
Ongoing symptomatic cardiac dysrhythmias, uncontrolled atrial fibrillation, or prolongation of the corrected QT interval defined as > 450 msec for males and > 470 msec for female
Corrected QT (QTc) interval =< 450 msec
Patients with prolonged corrected QT(QTc) interval defined as male > 450 msec and female > 470 msec
Corrected QT (QTc) interval > 470 msec (females) or > 450 msec (males)
Corrected QT interval (QTc) =< 470 msec (based on average of screening triplicates)
Subjects must have normal corrected QT interval (QTc) =< 470 msec (based on average of screening triplicates)
Baseline corrected QT (QTc) interval > 500 msec
Corrected QT interval (QTc) =< 480 msec per Fridericia’s formula AND PR interval =< 200 msec (using 12-lead electrocardiography [EKG])
Corrected QT interval (QTc) =< 480 msec
Patients with corrected QT interval (QTc) prolongation greater than Common Terminology Criteria for Adverse Events (CTCAE) grade 1 (> 480 msec); in addition, patients should not be receiving non-study medications known to prolong QTc
Corrected QT interval (QTc) =< 480 msec
Heart-rate corrected QT interval (QTc) prolongation > 470 msec at screening
Has QT interval corrected for heart rate (QTc) ?480 msec.
Have chronic atrial fibrillation or QTc interval corrected for heart rate of greater than 470 msec in adults and 450 msec in pediatrics (< 18 years).
Mean resting corrected QT interval (QTc) ?450 msec for males and ?470 msec for females.
Patients must have corrected QT (QTc) =< 500 msec
Corrected QT interval (QTc) < 480 msec
Corrected QT (QTc) interval > 500 msec; if QTc interval is > 500 msec, then 2 additional electrocardiograms (ECGs) should be obtained over a brief period of time (e.g., within 15-20 minutes) to confirm the abnormality; the average QTc interval will be determined from the 3 ECG tracings by manual evaluation and will be used to determine if the subject will be excluded from the study; the same method of QTc determination must be used throughout the subject’s participation in the trial
QT interval corrected (QTc) <450 millisecond (msec) or QTc <480 msec for patients with bundle branch block.
Mean resting correct QT interval (QTc) >470 msec obtained from triplicate electrocardiagrams
Grade 3 corrected QT interval (QTc) prolongation (QTc > 500 msec on two separate electrocardiograms (ECGs)
Subjects with a corrected QT interval (QTc) > 480 msec (QTc > 510 msec for subjects with bundle branch block) at baseline
Corrected QT interval (QTc) of > 480 msec using Bazett’s formula
No ongoing cardiac dysrhythmias, atrial fibrillation, or prolongation of corrected QT (QTc) interval to > 480 msec
Corrected QT (QTc) interval > 500 msec, unless a bundle branch block is also present
Patient with corrected QT (QTc) interval must be less than 500 msec
Patients must have corrected QT (QTc) < 500 msec
Corrected QTc > 470 msec; the corrected QTc may be corrected using either Bazett’s or Fridericia’s formula; in general Fridericia corrected QT interval (QTcf) is the preferred correction method
Corrected QT (QTc) interval > 470 msec
Corrected QT interval (QTc) (based on Bazett) > 450 msec on baseline ECG; if QTc > 450 msec and electrolytes are not within normal ranges, electrolytes should be corrected and then the patient re-screened for QTc
Bazett-corrected QT (QTcB) interval ?501 msec at the time of transition to this study
Corrected QT (QTc) interval >/= 480 msec at the time of transition to this study
Corrected QT interval (QTc) must be < 500 msec
Subjects with a corrected QT interval (QTc) <450 milliseconds (msec) or <480msec for subjects with bundle branch block. The QTc is the QT interval corrected for heart rate according to Fridericia's formula (QTcF), machine or manual overread. For subject eligibility and withdrawal, QTcF will be used. For purposes of data analysis, QTcF will be used. The QTc should be based on single or averaged QTc values of triplicate electrocardiograms (ECGs) obtained over a brief recording period
Participants with mean corrected QTc interval > 500 msec, as assessed within 4 weeks prior to enrollment, or participants who require medication known to prolong the QT interval
Corrected QT (QTc) (Frederica) prolongation > 470 msec
Corrected QT (QTc) interval =< 470 msec
Corrected QT interval (QTc) > 480 msec
Patients with a baseline QT/corrected QT (QTc) interval >= 501 msec
QTc (corrected QT) interval < 480 msec.
Corrected QT (QTc) interval > 450 msec (males) or > 470 msec (females)
Subjects with a QT interval corrected for heart rate according to Bazett's formula (QTcB) <450millisecond (msec) or <480msec for subjects with bundle branch block. The QTc should be based on single or averaged QTc values of triplicate electrocardiograms (ECGs) obtained over a brief recording period.
Corrected QT interval (QTc) of greater than 500 msec
Have chronic atrial fibrillation or QTc interval corrected for heart rate of greater than 470 msec.
Patient must have a QT/QTc interval ? 450 msec.
Corrected QT (QTc) interval > 500 msec
Corrected QT interval (QTc) ? 450 msec at least 7 days prior to registration for protocol therapy.
Patients with marked baseline prolongation of QT/corrected QT (QTc) interval (QTc interval > 450 msec for males or > 470 msec for females) using the Fridericia method for QTc analysis
Corrected QT interval (QTc) =< 480 msec
Patients with a known or screening-period-determined corrected QT (QTc) interval > 450 msec and patients who require a therapy with a drug known to prolong the QT/QTc interval, are ineligible
Corrected QT interval (QTc) =< 480 msec
Cardiovascular risk, including:\r\n* Poorly controlled hypertension, defined as either systolic > 170 or diastolic > 110\r\n* Congestive heart failure\r\n* Myocardial infarction within the past year\r\n* QT prolongation, defined as pretreatment corrected QT interval (QTc) > 440 msec in males or > 460 msec in females