Appropriate for protocol entry based upon the following minimum diagnostic workup:\r\n* History/physical examination including examination for encephalopathy, ascites, weight, height, and blood pressure within 14 days prior to study entry\r\n* Assessment by radiation oncologist and medical oncologist or hepatologist who specializes in treatment of HCC within 28 days prior to study entry\r\n* Pre-randomization scan (REQUIRED for all patients): Within 28 days prior to study entry, CT scan chest/abdomen/pelvis or positron emission tomography (PET) CT chest/abdomen/pelvis with multiphasic liver CT or multiphasic liver magnetic resonance (MR) scan (MRI of abdomen and pelvis with contrast with CT chest) is permitted
Absence of residual disease and absence of metastasis, as confirmed by a negative baseline computed tomography (CT) of the pelvis, abdomen, and chest no more than 4 weeks prior to randomization. Confirmation of disease-free status will be assessed by an independent central radiologic review of imaging data.
Baseline chest computed tomography (CT) with or without contrast must be performed within 6 months (180 days) prior to randomization to ensure no evidence of disease; if clinically indicated additional imaging studies must be performed to rule out metastatic disease
Investigations, including chest X-ray or computed tomography (CT) chest, bone scan (with radiographs of suspicious areas) and abdominal ultrasound or liver scan or CT abdomen have been performed between the first histologic diagnosis and the time of registration\r\n* Chest X-ray, 2 view (or chest CT, or positron emission tomography [PET]/CT) is required only if clinically indicated or recommended by National Comprehensive Cancer Network (NCCN) guidelines\r\n* Bone scans (with x-rays of abnormal areas) are required only if indicated or recommended by NCCN guidelines\r\n* Abdominal imaging is required only if clinically indicated or recommended by NCCN guidelines
Clinical stage: T2N1, T3N0, T3N1\r\n* N2 disease is to be estimated as four or more lymph nodes that are >= 10 mm\r\n* Clinical staging should be estimated based on the combination of the following assessments: physical exam by the primary surgeon, computed tomography (CT) or positron emission tomography (PET)/CT scan of the chest/abdomen/pelvis and either a pelvic magnetic resonance imaging (MRI) or an ultrasound (endorectal ultrasound [ERUS]); if a pelvic MRI is performed, it is acceptable to perform CT of the chest/abdomen, omitting CT imaging of the pelvis
Baseline chest computed tomography (CT) must be performed within 1 month (30 days) of randomization to ensure no evidence of disease; if clinically indicated, additional imaging studies must be performed to rule out metastatic disease
Contrast-enhanced computed tomography (CT) scans of the neck, chest, abdomen and pelvis are required; a whole body positron emission tomography (PET)/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the neck, chest, abdomen and pelvis; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the Baseline Tumor Assessment Form (RECIST 1.1)
The patient must have the following assessments done =< 8 weeks prior to randomization:\r\n* Examination by a head and neck surgeon\r\n* Chest x-ray (or chest computed tomography [CT] scan or CT/positron emission tomography [PET] of the chest or magnetic resonance imaging [MRI]) to rule out distant metastatic disease
Metastatic disease as evidenced by the presence of soft tissue and/or bone metastases on imaging studies (CT/magnetic resonance imaging [MRI] of abdomen/pelvis, bone scintigraphy or NaF PET/CT)
Patients must have no evidence of extrapelvic disease; complete workup staging should be performed prior to initiation of therapy to rule-out presence of metastatic disease; this should include: computed tomography (CT) scan of the thorax with IV contrast, as well as a CT of the pelvis and abdomen with IV and oral (PO) contrast performed using multi-detector CT and equal or less than 5 mm slice thickness; if the patient is unable to tolerate contrast, then magnetic resonance imaging (MRI) with IV gadolinium should be performed; a chest x-ray should be done first, and if abnormal, then a CT scan of the chest should be done
Any pT-stage based on American Joint Committee on Cancer 7th edition eligible; study entry will be based on the following diagnostic workup:\r\n* History/physical examination within 60 days prior to step 1 registration\r\n* Negative distant metastatic workup: \r\n** A computed tomography (CT) scan of the abdomen and pelvis (with contrast [CT without contrast is permitted if the patient is not a candidate for contrast, i.e., renal function or allergy]) or magnetic resonance imaging (MRI) of the pelvis within 120 days prior to step 1 registration; (Please note: Lymph nodes will be considered negative (NO)if they are =< 1.5 cm short axis);\r\n** Bone scan within 120 days prior to step 1 registration; (please note: a sodium fluoride [NaF] positron emission tomography [PET]/CT is an acceptable substitute and if the bone scan is suspicious, a plain x-ray, CT scan, NaF PET/CT and/or MRI must be obtained to rule out metastasis)
Contrast-enhanced computed tomography (CT) scans of the chest, abdomen and pelvis are required; a whole body positron emission tomography (PET)/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the chest, abdomen and pelvis; imaging of the head and neck is required only if the patient has a head/neck primary; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; if skin lesions are being followed as measurable disease, photograph with a ruler included and physician measurements, must be kept in the patient’s chart as source documentation; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the baseline tumor assessment form (RECIST 1.1)
Stage II-IVB disease (American Joint Committee on Cancer [AJCC], 7th edition [ed.]) with no evidence of distant metastasis, based upon the following minimum diagnostic workup:\r\n* History/physical examination by a Medical Oncologist or Clinical Oncologist or Radiation Oncologist or Ear, Nose, Throat specialist (ENT), which must include an endoscopic evaluation, a complete list of current medications, and assessment of weight and weight loss in the past 6 months within 21 days prior to registration\r\n* Evaluation of tumor extent with one of the following combinations required within 28 days prior to registration:\r\n** Magnetic resonance imaging (MRI) of the nasopharynx and neck; or computed tomography (CT) of the nasopharynx and neck with =< 3 mm contiguous slices with contrast and bone windows (to evaluate base of skull involvement). \r\n** MRI of the nasopharynx and positron emission tomography (PET)/CT (with contrast) of the neck\r\n*** Note: If a treatment planning CT scan is used, it must be with =< 3 mm contiguous slices with contrast and be read by a radiologist\r\n* To rule out distant metastasis, patients must undergo the following imaging within 28 days prior to registration:\r\n** A CT scan with contrast of the chest and abdomen (required), and the pelvis (optional), or a total body PET/CT scan (non-contrast PET/CT is acceptable)\r\n** A bone scan only when there is suspicion of bone metastases (a PET/CT scan can substitute for the bone scan)
Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 60 days prior to registration\r\n* Clinical grade computed tomography (CT) scans of the chest, abdomen, and pelvis with radionuclide bone scan OR whole body positron emission tomography (PET)/CT within 60 days prior to study registration
Patients with T1 disease must have cross-sectional imaging of abdomen/pelvis demonstrating no evidence of nodal involvement or metastatic disease (magnetic resonance imaging [MRI] or computed tomography [CT] scan) within 90 days prior to registration; patients with T1 disease must have re-resection confirming =< T1 disease within 90 days prior to registration
Patient must have computed tomography (CT) chest/abdomen/pelvis with contrast or fludeoxyglucose F-18 (FDG)-positron emission tomography (PET)/CT scan performed within 28 days prior to step 1 registration
Patient must have a CT of chest/abdomen with contrast or FDG-PET/CT scan within 28 days prior to step 2 registration; patients must not have evidence of progression per RECIST 1.1 or modified RECIST for pleural tumors
Patient must have a CT of chest/abdomen/pelvis with contrast or FDG-PET/CT scan within 28 days prior to step 3 registration; patient must not have evidence of progression per RECIST 1.1 or modified RECIST for pleural tumors
Patients with evidence of extramedullary disease at diagnosis will have computed tomography (CT) scan or magnetic resonance imaging (MRI) of the chest, abdomen and pelvis to obtain baseline values within 28 days prior to registration
The following imaging workup to document metastases within 45 days prior to study registration are required: CT scans of the chest, abdomen and pelvis with radionuclide bone scan OR whole body (at least skullbase to midthigh) positron emission tomography (PET)/CT
No evidence of metastatic cancer on imaging including a bone scan and computed tomography (CT) scan of chest/abdomen/pelvis
Patients with evidence of extramedullary disease at diagnosis will have computed tomography (CT) scan of the chest, abdomen and pelvis to obtain baseline values within 28 days prior to registration
Chest imaging =< 3 months of enrollment, including computed tomography (CT)-scan or chest x-ray
Systemic staging of the chest/abdomen (abd), pelvis is required for study entry; body fluid will be assessed based on this study
Positron emission tomography (PET)/CT scan including neck, chest, abdomen, pelvis within 4 weeks of study enrollment documenting the absence of distant metastases
Patients with N2 or N3 nodal disease or T3 primary disease must undergo liver and bone imaging (as described in 4.1.13 and 4.1.14) within 28 days prior to randomization, irrespective of baseline lab results, and studies must not demonstrate metastatic disease. Chest imaging with chest x-ray PA and Lateral, CT of the chest, or PET-CT must also be performed.
Scans used to determine eligibility (CT scan of the chest/abdomen/pelvis and liver) must be performed within 28 days prior to initiation of Induction Phase treatment.
Metastatic disease identified via radiographic assessment by computed tomography (CT) scans of the chest, abdomen, pelvis, and nuclear bone scan; magnetic resonance imaging (MRI) may be used if deemed necessary by the investigator; more specifically, patients must have at least one of the following at time of study enrollment:\r\n* Any visceral metastases identified by CT scans or MRI\r\n* Site(s) of bony metastasis identified by nuclear bone scan, MRI, and/or CT scan\r\n* Lymph node based disease not considered to be within a single radiation therapy port (e.g. at or above the aortic bifurcation)
Absence of residual disease and absence of metastasis, as confirmed by a negative baseline computed tomography (CT) or magnetic resonance imaging scan of the pelvis, abdomen, and chest no more than 4 weeks prior to randomization
Patient has one or more metastatic tumors evaluable by CT scan with contrast (or MRI, if patient is allergic to CT contrast media) per RECIST 1.1. Imaging investigations including CT/MRI of chest/abdomen/pelvis or other scans as necessary to document all sites of disease must be performed within 14 days prior to randomization. Qualifying scans performed as part of standard of care prior to patient signature of the study informed consent will be acceptable as baseline scanning as long as scanning is performed < 14 days prior to randomization.
Patients must have staging scans with abdominal/pelvic computed tomography (CT) or magnetic resonance imaging (MRI) scan, and CT scan or x-ray of the chest within 56 days prior to registration; if the alkaline phosphatase is > 1.5 x upper limit of normal (ULN), there is a presence of suspicious bone pain, or if there is other clinical suspicion of bone metastases, a whole body bone scan is required within 56 days prior to registration
Prior to chemotherapy +/- or thoracic radiotherapy, patients must be defined as limited-stage or extensive-stage SCLC after clinical staging evaluation involving the following:\r\n* History/physical examination;\r\n* Computed tomography (CT) of the chest and abdomen with contrast (does not have to be done if the patient has had a positron emission tomography (PET)/CT scan prior to initiating chemotherapy or thoracic radiotherapy)\r\n* MRI of the brain with contrast or diagnostic head CT with contrast\r\n* For patients without evidence of extensive-stage SCLC on chest and abdomen CT and brain MRI or head CT, a PET/CT or bone scan is required to confirm limited-stage SCLC
Patients must have had at least a computed tomography (CT) of the chest, abdomen, and pelvis within 4 weeks of registration in the trial; CT or magnetic resonance imaging (MRI) of the brain is only required in the presence of neurologic symptoms
Stage III A or B disease, including no distant metastases- based on following diagnostic workup:\r\n* History/physical examination prior to registration\r\n* Computed tomography (CT) scan of the chest or positron emission tomography (PET) scan within 28 days of study entry\r\n* CT scan of abdomen or magnetic resonance imaging (MRI) of abdomen or PET scan within 28 days of study entry\r\n* An MRI of the brain or head CT scan with contrast within 28 days of study entry\r\n* Total body PET scan within 28 days of study entry\r\n* Mediastinoscopies are highly recommended
Subjects must be free of visible disease on imaging (computed tomography [CT], positron emission tomography CT [PETCT] or magnetic resonance imaging [MRI]) evaluating chest, abdomen, and pelvis within 28 days of enrollment on the study
Patients with muscle-invasive (i.e. T2, T3, T4), locally advanced non-resectable, or metastatic urothelial carcinoma as assessed on baseline radiographic imaging obtained within 28 days prior to study registration; the required radiographic imaging includes:\r\n* Abdomen/Pelvis – computed tomography (CT) scan\r\n* Chest – chest x-ray or CT scan
Has visceral metastases with >= 3 lung and/or liver metastases or individual lesion >= 2 cm, as assessed by computed tomography (CT) scan or magnetic resonance imaging (MRI) of the chest/abdomen/pelvis within the last 8 weeks prior to randomization
Clinical stage T1N0, T2N0, T3N0; high risk T1 and low risk T3 stage patients are also allowed. Clinical staging should be estimated based on the combination of the following assessments: physical exam by the primary surgeon, computed tomography (CT) chest/abdomen/pelvis or positron-emission tomography (PET)/CT along with pelvic MRI and endoscopic rectal ultrasound (ERUS). If a pelvic MRI is performed, it is acceptable to perform CT of the chest/abdomen, omitting CT imaging of the pelvis.
Locoregional lymph node metastases are permitted but patients with distant metastases are ineligible; imaging to evaluate for distant metastases should consist of a minimum of computed tomography (CT)/magnetic resonance imaging (MRI) of abdomen/pelvis or CT urogram and a chest x-ray (CXR) or CT chest; patients for which there is clinical suspicion or symptoms of bone metastasis should have a bone scan completed to rule out metastatic disease prior to enrollment on study
To be eligible for randomization, patients must: \r\n* Meet all the inclusion criteria;\r\n* Have no progression of disease after 6-12 weeks of osimertinib per RECIST 1.1. (To assess for progressive disease patients must have the following imaging: \r\n** Either a positron emission tomography (PET)/computed tomography (CT) scan or a CT scan of the chest/abdomen/pelvis (or CT chest) ** A CT scan or a magnetic resonance imaging (MRI) of the brain);\r\n* Have target lesions (lesions that will be treated with LCT if the patient is randomized to that arm). Patients that have a complete response (CR) to front-line osimertinib (e.g. no visible disease to target) will continue to be followed for progression on study but will not be randomized
Must be tumor-free as assessed by the Investigator and validated by either computed tomography (CT) or magnetic resonance imaging (MRI) scan of the brain and chest, abdomen, and pelvis and a bone scan ?28 days from randomization.
Absence of baseline imaging studies (CT abdomen/pelvis and Chest x-ray minimum) both prior to beginning chemotherapy and following chemotherapy
Locally advanced or metastatic disease not amenable to surgery with curative intent with measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as determined by the investigator based on an assessment of all known disease sites by computerized tomography (CT) scan or magnetic resonance imaging (MRI) of chest/abdomen/pelvis within 28 days before the first dose of cabozantinib. In patients with intravenous (IV) contrast allergy or borderline renal function, CT without IV contrast or 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) CT may be used as clinically indicated.
Metastatic disease as evidenced by soft tissue and/or bony metastases on baseline bone scan and/or computed tomography (CT) scan of the chest, abdomen, and pelvis
Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination within 28 days prior to registration;\r\n* Computed tomography (CT) imaging of the chest, abdomen and pelvis within 28 days prior to registration documenting disease consistent with FIGO stage Ill or IV disease (patients who cannot receive contrast may instead undergo magnetic resonance imaging [MRI] of abdomen and pelvis along with non-contrast chest CT);
Pretreatment computed tomography (CT) chest /abdomen /pelvis within 28 days of protocol enrollment
Has had restaging imaging after initiation of immunotherapy, at least 4 weeks after pre-immunotherapy baseline imaging; computed tomography (CT) or positron emission tomography (PET)/CT of at least chest/upper abdomen must be performed within 4 weeks prior to registration; for patients with history of brain metastases, brain magnetic resonance imaging (MRI) or CT is required within 4 weeks of registration; for other patients brain MRI or CT is required within 12 weeks of registration; diagnostic PET/CT performed as part of radiation simulation can be used as the restaging imaging
Measurable disease on computed tomography (CT) scan of thorax, abdomen, and pelvis per RECIST v1.1 criteria
Patients with locally advanced unresectable or metastatic urothelial carcinoma as assessed on baseline radiographic imaging obtained within 28 days prior to study registration; the required radiographic imaging includes:\r\n* Abdomen/Pelvis – computed tomography (CT) scan\r\n* Chest – chest x-ray or CT scan
Patients will undergo CT imaging of the chest, abdomen, and pelvis to evaluate lung and liver metastases within 30 days of registration; for patients who cannot tolerate CT contrast or have hepatic steatosis that reduces the sensitivity of CT, MRI of the liver will be performed
Surgically resectable (T2N0, T3N0, Tany with node positivity, M0), as determined by endoscopic ultrasound (EUS) and the following minimum diagnostic work-up:\r\n* Whole-body PET/computed tomography (CT) (PET/CT of skull base to mid-thigh is acceptable)\r\n* EUS =< 21 days prior to registration\r\n* NOTE: Patients may have regional adenopathy including para-esophageal, gastric, gastrohepatic and celiac nodes; if celiac adenopathy is present, it must be < 2 cm\r\n* NOTE: If patient unable to have PET/CT then CT chest/abdomen/pelvis with contrast (preferred) or MRI chest/abdomen/pelvis with contrast
No evidence of metastases other than regional lymphadenopathy as assessed by imaging of the chest, abdomen and pelvis with CT of the chest and CT or MRI of the abdomen; regional lymph nodes, per 7th edition American Joint Committee on Cancer (AJCC) staging manual (2010) for kidney cancer, include the following positions: renal hilar, precaval, paracaval, retrocaval, interaortocaval, paraaortic, preaortic, and retroaortic
No evidence of metastasis on staging computed tomography (CT) scans of the chest, abdomen and pelvis
No distant metastases, based on the following workup within 60 days prior to registration\r\n* Magnetic resonance imaging (MRI) of the pelvis or computed tomography (CT) abdomen/pelvis (A/P)\r\n* Bone scan or sodium fluoride positron emission tomography (PET), that if suspicious has MRI or plain X-rays to rule out bone metastasis
Radiographically measurable or clinically evaluable disease by computed tomography (CT) scan of chest/abdomen/pelvis with and without contrast =< 28 days prior to registration
No evidence of metastatic disease based on imaging of the chest, abdomen and pelvis
Computed tomography of the chest, abdomen, and pelvis (CT CAP) and bone scan performed within 30 days prior to study entry and does not demonstrate metastatic disease
Within 60 days of registration: patients must have fludeoxyglucose F 18 (FDG)-positron emission tomography (PET)-CT scan (or CT chest/abdomen/pelvis with IV contrast), and magnetic resonance imaging (MRI) brain with IV contrast (preferred) or CT scan of the brain with contrast; non-contrast MRI scans of the chest/abdomen/pelvis or brain are permitted for workup if patient has allergy to CT contrast or renal insufficiency
Patients must have a CT of chest, abdomen, and pelvis with PET within 28 days of enrollment; patients with evidence of lymphadenopathy in the neck must have a dedicated CT of neck
Patients must have a computed tomography (CT) (preferred) or magnetic resonance imaging (MRI) scan of the chest, abdomen, and pelvis within 28 days of enrollment
Uncontrolled infections, defined as positive blood cultures within 72 hours of study entry, or evidence of progressive infection by imaging studies such as chest computed tomography (CT) scan within 14 days of registration
Patients with no evidence of distant metastatic disease based on CT scan of the chest/abdomen/pelvis; diagnostic laparoscopy, is recommended but not required and is at the discretion of the surgical oncologist; peri-pancreatic or regional lymphadenopathy that does not preclude a surgical resection is acceptable
Participants must have no clinical, radiographic, or laboratory evidence of cancer dissemination to the peritoneal cavity, chest cavity, or spread via hematogenous dissemination; computed tomography (CT) or positron emission tomography (PET)/CT of the chest, abdomen and pelvis must have been obtained within 10 weeks of study entry; there must be no measurable (macroscopic) disease within the radiation target volume following hysterectomy and lymphadenectomy
Baseline imaging in the form of CT chest, abdomen, pelvis with oral and intravenous contrast within 28 days of study entry; for patients with a contrast allergy, choice of alternative body imaging will be at the discretion of the investigator or his designee; magnetic resonance imaging (MRI) of the brain is only needed if clinically indicated
Patients must have no evidence of metastatic disease based on routine imaging (computed tomography [CT] or magnetic resonance imaging [MRI] of the chest/abdomen/pelvis, bone scan, etc.)
No distant metastases, based upon the following minimum diagnostic workup:\r\n* History and physical exam including a detailed description of the location, size and stage of the sarcoma, within 10 weeks prior to study entry\r\n* CT or magnetic resonance imaging (MRI) with contrast of the abdomen and pelvis within 8 weeks prior to study entry; the maximal dimension of the primary tumor will be measured in CT and MRI images; and\r\n* CT scan of the chest within 8 weeks prior to study entry
Participants with multifocal disease, lymph node or distant metastases; Note: multiple pulmonary nodules < 8 mm without a histological diagnosis detected incidentally in a non-screening CT scan may not be a basis for study exclusion because of the sensitivity/specificity of the CT scans of the chest/abdomen/pelvis
CT, magnetic resonance imaging (MRI), or PET/CT imaging of the chest, abdomen, and pelvic regions within 42 days prior to registration (for stage I patients, posterior-anterior [PA] and lateral chest x-ray is sufficient for chest imaging)
MRI/CT of brain within 42 days of lymphodepletion; CT scan of chest/abdomen/pelvis or PET/CT within 30 days of lymphodepletion; Exception: patients randomized to receive dendritic cells may have an MRI of the brain within 30 days of lymphodepletion (Turnstile II-Chemotherapy/Cell Infusion-Inclusion Criteria)
Patients must have imaging of the chest/abdomen/pelvis, preferably with a computed tomography (CT) scan, and a bone scan within 4 weeks prior to randomization; (NOTE: if a patient is unable to receive CT contrast, a magnetic resonance imaging [MRI] of the abdomen/pelvis and non-contrast chest CT should be performed; positron emission tomography/computed tomography [PET/CT] is not an acceptable alternative)
No evidence of metastatic disease on baseline imaging (chest x-ray [CXR] or chest CT, abdominal CT or MRI)
BLADDER: Patients may not have evidence of metastatic disease on baseline computed tomography (CT) or magnetic imaging resonance of the chest, abdomen, or pelvis
Patients must have a FDG-PET-computed tomography (CT) of chest, abdomen, and pelvis within 28 days of enrollment
Definitive clinical or radiologic evidence of metastatic disease; required imaging studies must have been performed within 28 days prior to randomization; Note: Distant clinical staging to exclude patients with overt metastatic disease is determined by:\r\n* Chest: CT scan (preferred); chest x-ray posterioranterior (PA) and lateral (acceptable); or positron emission tomography (PET) scan (acceptable)\r\n* Abdomen: CT scan with IV contrast (preferred); or MRI (acceptable)\r\n* Pelvis: MRI (preferred) or CT scan with IV contrast (acceptable)\r\n** (It is recommended that the same imaging tests that are performed before randomization be used at follow-up time points; Note: CT scans of the abdomen and pelvis must be performed with IV contrast)
Pathologic stage III or IV HNSCC, including no distant metastases, based on the following minimum diagnostic workup:\r\n* General history/physical examination by a radiation oncologist and/or medical oncologist within 84 days prior to registration\r\n* Examination by an ear nose and throat (ENT) or head & neck surgeon prior to surgery; a laryngopharyngoscopy (mirror and/or fiberoptic and/or direct procedure), if appropriate, is recommended but not required; intra-operative examination is acceptable documentation\r\n* Pre-op Imaging of the head and neck: a neck computerized tomography (CT) (with contrast) or CT/positron emission tomography (PET) (with contrast) and/or an magnetic resonance imaging (MRI) of the neck (T1 with gadolinium and T2) within 84 days prior to surgery; note: this imaging data (diagnostic pre-operative scan showing gross disease) is to be submitted in Digital Imaging and Communications in Medicine (DICOM) format via transfer of images and data (TRIAD); the report is to be uploaded into Rave\r\n* Chest imaging with either a CT scan (with or without contrast) or CT/PET (with or without contrast) that includes the chest within 120 days prior to registration; Note: if the CT/PET with or without contrast is done within 84 days prior to surgery, it fulfills the chest imaging requirement
Pathologic stage III or IV HNSCC, including no distant metastases, based upon the following minimum diagnostic workup:\r\n* General history and physical examination by a radiation oncologist and/or medical oncologist within 84 days prior to registration;\r\n* Examination by an ear nose throat (ENT) or head & neck surgeon prior to surgery; a laryngopharyngoscopy (mirror and/or fiber optic and/or direct procedure), if appropriate, is recommended but not required; intra-operative examination is acceptable documentation\r\n* Pre-operative (op) Imaging of the head and neck: A neck computed tomography (CT) (with contrast) or CT/positron emission tomography (PET) (with contrast) and/or an magnetic resonance imaging (MRI) of the neck (T1 with gadolinium and T2) within 84 days prior to surgery; Note: this imaging data (diagnostic pre-operative scan showing gross disease) is to be submitted in Digital Imaging and Communications in Medicine (DICOM) format via TRIAD; the report is to be uploaded into Rave\r\n* Chest CT scan (with or without contrast) or CT/PET that includes the chest (with or without contrast) either within 84 days prior to surgery or within 120 days prior to registration; Note: if the CT/PET with or without contrast is done within 84 days prior to surgery, it fulfills the chest imaging requirement
Metastatic disease as demonstrated by bone scan, computed tomography (CT) scan or magnetic resonance imaging (MRI) of the pelvis, or chest x-ray
The patient must be free of unresectable metastatic disease within 4 weeks prior to the surgery being performed with the intention to remove all melanoma; this pre-surgery baseline assessment must be documented by complete physical examination and imaging studies; imaging studies must include a total body positron emission tomography (PET)-computed tomography (CT) in conjunction with a brain magnetic resonance imaging (MRI) (or head CT if brain MRI is contraindicated); if a PET/CT scan cannot be done, a CT of the neck, chest, abdomen, and pelvis should be performed
All patients must have disease-free status documented by a complete physical examination and imaging studies within 4 weeks prior to randomization; imaging studies must include a total body positron emission tomography (PET)-computed tomography (CT) scan (with or without brain) and brain magnetic resonance imaging (MRI) or CT (if MRI is contraindicated); if PET-CT cannot be done, CT of neck, chest, abdomen, and pelvis should be done\r\n* If for some reason a CT cannot be done, an MRI may be done instead; any other imaging studies if performed (eg, bone scan) must show no evidence of disease
Negative metastatic workup with bone scan and computed tomography (CT) abdomen/pelvis, within 6 months of study treatment, if indicated by PSA > 10
Computed tomography (CT) chest, abdomen, and pelvis performed
Clinical stage T1-T2, N1-N2b or T3, N0-N2b (American Joint Committee on Cancer [AJCC], 7th edition [ed.]) including no distant metastases based on the following diagnostic workup:\r\n* General history and physical examination within 56 days prior to registration\r\n* Fiberoptic exam with laryngopharyngoscopy (mirror and/or fiberoptic and/or direct procedure) within 70 days prior to registration\r\n* One of the following combinations of imaging is required within 56 days prior to registration:\r\n** A CT scan of the neck (with contrast) and a chest CT scan (with or without contrast)\r\n** Or a magnetic resonance imaging (MRI) of the neck (with contrast) and a chest CT scan (with or without contrast)\r\n** Or a CT scan of neck (with contrast) and a PET/CT of neck and chest (with or without contrast)\r\n** Or an MRI of the neck (with contrast) and a PET/CT of neck and chest (with or without contrast)\r\n*** Note: a CT scan of neck and/or a PET/CT performed for the purpose of radiation planning may serve as both staging and planning tools
Computerized tomography (CT) urogram or magnetic resonance imaging (MRI) urogram; if urogram protocol not available or contrast allergy/poor renal function preclude such imaging, then noncontrast CT or MRI of the abdomen/pelvis within 45 days of study entry will suffice
No distant metastases, based upon the following minimum diagnostic workup:\r\n* History/physical examination within 30 days prior to registration\r\n* Whole body fludeoxyglucose F 18 (FDG)-positron emission tomography (PET)/CT within 30 days prior to registration\r\n** NOTE: if whole-body FDG-PET/CT is not performed, CT of the chest and CT (or MRI) of abdomen and pelvis must be obtained (imaging of abdomen and pelvis need not be repeated if already included in pancreas protocol study)
Metastatic disease as evidenced by soft tissue and/or bony metastases on baseline bone scan and/or computed tomography (CT) scan or magnetic resonance imaging (MRI) of the abdomen or pelvis
Appropriate stage for protocol entry, including no distant metastases, based upon the following minimum diagnostic workup:\r\n* History/physical examination within 45 days prior to registration\r\n* Computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET)-CT including the abdomen and pelvis should be performed for initial radiological staging; this may be performed pre- or post-surgery within 90 days prior to registration; imaging performed post-operatively should show no evidence of residual disease; any evidence of malignancy identified on pre-operative imaging should have been completely resected surgically prior to protocol treatment; chest CT or chest x-ray must be performed within 90 days prior to registration (unless a PET-CT has been performed)
Appropriate diagnostic imaging performed including a CT or MRI of the brain and CTs of the thorax, abdomen, pelvis; CT of the neck and imaging of the extremities may be indicated depending on the clinical presentation must be complete and satisfactory within 30 days of initiation of chemotherapy
Histologically documented adenocarcinoma of the prostate with metastatic disease as evidenced by soft tissue (e.g. lymphoid) and/or bony metastases on baseline computed tomography (CT) scan of the abdomen and pelvis and/or bone scan
CT scan or sim CT of chest and upper abdomen (IV contrast is recommended unless medically contraindicated) within 6 weeks prior to registration
No evidence of systemic non-Hodgkin lymphoma as demonstrated by a computed tomography (CT) scan of the chest, abdomen, and pelvis within 6 weeks prior to registration (note: bone marrow biopsy is not required for registration but must be obtained prior to start of treatment)
Patients will have a baseline computed tomography (CT) chest, abdomen and pelvis within 30 days of registration
The following minimum diagnostic workup is required:\r\n* History/physical examination within 2 weeks prior to registration\r\n* Imaging of neck and brain (computed tomography [CT] scan or magnetic resonance imaging [MRI]) and chest/abdominal imaging (chest x-ray or chest CT scan, or full body positron emission tomography [PET]/CT are acceptable) within 4 weeks prior to registration\r\n* Note: the CT scan of the neck must be done with contrast or if an MRI is done, with gadolinium; therefore, the CT portion of a full body PET/CT has to be a high resolution CT to be acceptable for eligibility\r\n* Abdominal imaging must cover the liver and adrenal glands; therefore, separate imaging is not required if these areas are covered by a chest CT scan\r\n* Electrocardiogram within 10 days prior to registration
Patients must have staging scans with abdominal/pelvic computed tomography (CT) or magnetic resonance imaging (MRI) scan and CT scan or x-ray of the chest within 56 days prior to registration; if alkaline phosphatase is above the treating institution’s upper limit of normal (ULN), presence of suspicious bone pain, or if other clinical suspicion, a whole body bone scan is required within 56 days prior to registration
All patients must have disease-free status documented by a complete physical examination and imaging studies within 42 days prior to registration; imaging studies must include a total body positron emission tomography (PET)-computed tomography (CT) scan that is of diagnostic quality (with or without brain) or a CT of the chest, abdomen and pelvis; for patients with melanoma arising from the head and neck, dedicated neck imaging (CT with IV contrast or PET-CT through the region) is required; if the patient has had unknown primary with disease in the axilla, neck imaging is required to assure region is clear of cancer; CT imaging should be done with intravenous contrast if there are no contraindications for it; any other clinically-indicated imaging studies if performed (e.g. bone scan) must show no evidence of disease
Patients must not have any evidence of residual or metastatic renal cell cancer on computed tomography (CT) scan of the chest, abdomen, and pelvis, all with oral and intravenous (IV) contrast after nephrectomy and within a maximum of 28 days prior to registration; a magnetic resonance imaging (MRI) scan of the abdomen/pelvis with gadolinium and a non-contrast CT of the chest is an acceptable imaging alternative; non-contrast CT of the chest/abdomen/pelvis should only be performed if, in the opinion of the investigator, it is in the best medical interest of the patient to not receive IV contrast of any form; NOTE: positron emission tomography (PET)/CT is not an acceptable imaging alternative; patients who display subcentimeter pulmonary nodules (by CT scan) that are non-specific and considered unlikely to represent metastatic disease by the treating investigator will be considered eligible
All patients must have no evidence of persistent or metastatic disease as documented by a post-resection computed tomography (CT) of the chest/abdomen/pelvis or by CT chest + magnetic resonance imaging (MRI) abdomen/pelvis; the post-resection imaging studies should be performed within 4 weeks of registration on study
Abdominal/pelvic computed tomography (CT) scan with contrast is preferred; abdominal CT alone is acceptable only if insurance restrictions are experienced; chest CT/x-ray (CT of chest preferred) within 31 days of registration on study (or within 31 days prior to day 1 of chemo post-surgery for those patients having started chemotherapy prior to first step registration); patients allergic to intravenous (IV) contrast can have magnetic resonance imaging (MRI) of the abdomen/pelvis instead
Clinical stage T1, N1-2 or T2-4a, N0-2, M0 including no distant metastases, based upon the following minimum diagnostic workup:\r\n* General history and physical examination by a radiation oncologist and/or medical oncologist within 8 weeks prior to registration\r\n* Examination by an ear, nose and throat (ENT) or head & neck surgeon, within 8 weeks prior to registration; a laryngopharyngoscopy (mirror and/or fiberoptic and/or direct procedure) is recommended but not required\r\n* Chest x-ray (at a minimum) or chest computed tomography (CT) scan (with or without contrast) or CT/positron emission tomography (PET) of chest (with or without contrast) within 8 weeks prior to registration
Imaging (positron emission tomography/computed tomography (PET/CT) scan, CT scan, or magnetic resonance imaging (MRI)) of chest, abdomen, and pelvis must be performed within 90 days prior to randomization and must demonstrate no evidence of metastatic disease. If findings noted in imaging study reports are equivocal, the determination of whether or not the findings represent metastatic disease will be at the investigator's discretion.
Patients must have metastatic disease. Baseline imaging of chest, abdomen and pelvis (CT or MRI) within 21 days prior to initiation of protocol therapy is required.
Participants must have histologically or cytologically confirmed invasive squamous, basaloid, or cloacogenic carcinoma of the anal canal; pathology must be reviewed by the treating institution; patients must be clinically staged as T stage 1-4 and N0-N3 stage, based upon the following minimum diagnostic work-up:\r\n* History/physical examination within 42 days prior to registration\r\n* Anal examination with mandatory biopsy and any of the following: colonoscopy, sigmoidoscopy, rigid proctoscopy, or anoscopy; digital rectal examination (performed at the discretion of the treating physician) with documentation of primary anal lesion size, distance from the anal verge, and anal tone is also recommended\r\n* Groin examination with documentation of any groin adenopathy and lymphadenopathy (location: right vs. left, medial vs. lateral, mobile vs. fixed, and size)\r\n* A biopsy is not needed for pathologically enlarged or clinically suspicious inguinal, perirectal, or pelvic lymph nodes on examination, computed tomography (CT) scan, or positron emission tomography (PET)/CT and will be considered clinically positive\r\n* No evidence of distant metastatic disease as determined by CT scan with contrast, or PET/CT scan of the chest within 42 days prior to registration and CT scan with contrast, magnetic resonance imaging (MRI), or PET/CT of the abdomen and pelvis within 42 days prior to registration
The following imaging workup to document metastases within 45 days prior to study registration: \r\n* Computed tomography (CT) scans of the chest, abdomen and pelvis with radionuclide bone scan OR whole body positron emission tomography (PET)/CT
To rule out metastatic disease, patients must have the following tests:\r\n* Bone scan within 60 days prior to registration\r\n* Computed tomography (CT) of abdomen/pelvis within 60 days prior to registration
Negative radiographic metastatic work-up including whole body radionuclide bone scan, computed tomography (CT), and/or magnetic resonance (MR) scan of the pelvis and abdomen, and chest x-ray; patients with suspicious areas on conventional imaging studies may be included if they are biopsy negative
Contrast enhanced CT of the chest and upper abdomen
Evidence of metastatic disease as determined by chest computed tomography (CT) scan, abdomen/pelvis CT scan (or magnetic resonance imaging [MRI] with gadolinium and/or manganese) within six weeks of study entry; distant nodal disease is allowed if it is in the radiation port
Baseline bone scan, chest x-ray and computed tomography (CT)/magnetic resonance imaging (MRI) of abdomen/pelvis demonstrating no metastatic disease
A bone scan and a CT or MRI abdomen/pelvis and chest x-ray (CXR) or chest CT scan, will have been performed within 12 weeks of treatment start; radiographic assessments will be selected by the attending physician as clinically indicated
Prior radiation to the chest or abdomen
There should be no evidence of metastatic disease on imaging of the chest, abdomen, and pelvis; this imaging should be either a contrast-enhanced computed tomography (CT) scan, or a contrast-enhanced magnetic resonance imaging (MRI) scan; positron emission tomography (PET) scans alone will not be adequate alternatives; there should be no evidence of occult metastatic disease in the abdomen, confirmed by laparoscopic examination
Clinically determined to be clinically staged (American Joint Committee on Cancer [AJCC] 7th edition [ed.]) T3-4 N0 M0 or T any N1-2 M0 based upon the following minimum diagnostic workup within 90 days prior to registration:\r\n* Colonoscopy\r\n* History/physical examination (including medication history screen for contraindications)\r\n* Contrast-enhanced imaging of the abdomen and pelvis either by computed tomography (CT), magnetic resonance imaging (MRI), or whole body positron emission tomography (PET)-CT (preferred)\r\n* Chest x-ray (or CT) of the chest to exclude distant metastases (except for those who have had whole body PET-CT per above bullet point)\r\n* Transrectal ultrasound (TRUS) or MRI for T staging
Metastatic disease as evidenced by both lymphadenopathy and bony metastases or just bony metastases on baseline bone scan and/or computed tomography (CT) scan or magnetic resonance imaging (MRI) of the abdomen and pelvis within 28 days of registration; chest imaging is only required if clinically indicated or if there is known disease in the chest
Visceral metastases as assessed by chest, abdominal or pelvic computed tomography (CT) (or other imaging modality)
For all patients a bone scan must be performed within 60 days prior to registration for tumor assessment; computed tomography (CT) scans (abdomen and pelvis) and chest x-ray are optional, but must be repeated if used for disease assessment; for late induction registrations, tumor assessment imaging showing metastatic disease must be available prior to start of androgen deprivation therapy
Patients must have non-metastatic (M0) disease, as defined by a lack of metastases seen on computed tomography (CT) scan of the chest/abdomen/pelvis and whole-body radionuclide 99Tc (technetium-99) bone scan, (or sodium fluoride positron emission tomography [PET] scan) taken within 3 months of study entry
Imaging with positron emission tomography (PET) scan, computed tomography (CT) scan of the abdomen and pelvis, and/or magnetic resonance imaging (MRI) of the abdomen and pelvis must be performed and negative for metastatic disease within 12 weeks of enrollment
Evidence of metastatic disease as evidenced by a computed tomography (CT) or magnetic resonance imaging (MRI) of abdomen and pelvis and/or whole body bone scan (WBS); to be done prior to treatment start and up to 4 months prior to radical prostatectomy date
No evidence of regional nodal or distant metastases based on computed tomography (CT) abdomen and pelvis and whole body bone scan within 120 days prior to study entry; nodes less than 1.5 cm will be considered reactive and biopsy is not required; nodes 1.5 cm or larger are required to undergo biopsy and be negative prior to study registration; bone scan findings in the absence of blastic or lytic lesion correlates on CT imaging will also be deemed non-neoplastic
No evidence of metastatic disease as determined by chest computed tomography (CT) scan, abdomen/pelvis CT scan (or magnetic resonance imaging [MRI] with gadolinium and/or manganese); all patients must be staged with a physical exam, chest CT, abdominal CT with intravenous contrast (or abdominal MRI with gadolinium and/or manganese)
No evidence of metastatic disease on imaging by whole body bone scan and computerized tomography (CT) or Magnetic Resonance Imaging (MRI) of the abdomen/pelvis within 6 weeks prior to randomization
Participants must not have metastatic disease; pre-operative chest CT scan is required within 10 weeks prior to registration; patients with overt evidence of lung metastatic disease are excluded from the study; however, because of the sensitivity/specificity of the chest CT, small incidental lesions without a histologic diagnosis may not be a basis for study exclusion
Metastatic disease as evidenced by the presence of soft tissue and/or bone metastases on imaging studies (computed tomography [CT] of abdomen/pelvis, bone scintigraphy)
No evidence of metastatic disease as determined by chest computed tomography (CT) scan, abdomen/pelvis CT scan (or magnetic resonance imaging [MRI] with gadolinium and/or manganese) within six weeks of study entry; all patients must be staged with a physical exam, chest CT, abdominal CT with intravenous contrast (or abdominal [abd] MRI with gadolinium and/or manganese)
Appropriate stage for protocol entry, based upon the following minimum diagnostic workup:\r\n* History and physical examination, including a complete list of current medications\r\n* Chest x-ray (posteroanterior [PA] and lateral views)\r\n* Abdominal/pelvic computed tomography (CT) scan\r\n* Brain magnetic resonance imaging (MRI) if clinically indicated\r\n* Bone scan if clinically indicated
Subjects must have baseline (screening/baseline) radiographic images, (e.g. brain, chest, abdomen, pelvis, and bone scans with specific imaging tests to be determined by the attending physician) within 6 weeks of initiation of ipilimumab
Patients must not have evidence of bone metastases or lymph node involvement as determined by bone scan or computed tomography (CT) scan of the abdomen and pelvis within 4 weeks of study entry; Note: NaF-PET/CT scan information will NOT be used to determine evidence of metastases for eligibility purposes or for defining disease progression
Patients must have no evidence of visceral or nodal metastatic disease proximal to the common iliac bifurcation on 2 view chest x-ray or computed tomography (CT) of the chest and abdominal-pelvic imaging with computerized tomography or magnetic resonance imaging (MRI) of the abdomen and pelvis; chest x-ray or CT of the chest and CT or MRI of the abdomen and pelvis must be obtained within 56 days prior to registration; positron emission tomography (PET)/CT may be used as an alternative to CT or MRI or to resolve possible areas of metastases seen on cross sectional imaging
Metastatic disease or regional lymph node involvement. Chest CT will be mandatory prior to enrollment to evaluate for the presence of metastatic disease. Pulmonary nodule(s) < 5 mm without a histological diagnosis may not be the basis for study exclusion given the lack of specificity of chest CT. If pulmonary nodule(s) > 5 mm are noted on chest CT but appear stable relative to prior chest imaging of at least 6 months duration, then this is permitted.
Negative CT scans of the chest, abdomen, and pelvis within 6 months prior to enrollment to rule out possibility of metastases;
Patients must have the following within 4 weeks prior to registration:\r\n* Computed tomography (CT) chest with intravenous (IV) and oral agent\r\n* CT pelvis/abdomen with IV and oral agent\r\n* MRI brain with gadolinium\r\n* For patients with known bone metastases, elevated alkaline phosphatase or symptoms raising suspicion of bone metastases, a baseline bone scan is required
Computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET)/CT imaging of the chest, abdomen, and pelvic regions within 60 days prior to registration (for stage I patients, posteroanterior [PA] and lateral chest x-ray is sufficient for chest imaging)
Appropriate stage for study entry based on the following diagnostic workup:\r\n* History/physical examination =< 45 days prior to registration;\r\n* Computed tomography (CT) chest, CT or magnetic resonance imaging (MRI) or positron emission tomography (PET)-CT that includes abdomen and pelvis should be performed for initial radiological staging; this may be performed pre- or post-surgery =< 90 days prior to registration except in patients getting postoperative adjuvant chemotherapy, who will require CT, MRI or PET-CT including the chest and abdomen and pelvis no more than 30 days prior to registration; imaging performed postoperatively should show no evidence of residual disease
Appropriate stage for protocol entry, including no distant metastases, based upon the following minimum diagnostic workup:\r\n* History/physical examination within 30 days prior to registration \r\n* Assessment by medical oncologist who specializes in treatment of IHC within 30 days of registration \r\n* Pre-randomization scan (REQUIRED for all patients): computed tomography (CT) scan chest/abdomen/pelvis with multiphasic liver CT scan within 30 days prior to registration; if CT contrast is contraindicated, CT chest without contrast and magnetic resonance imaging (MRI) of abdomen and pelvis is permitted
Have had a CT or MRI scan (chest, abdomen, pelvis and other suspected sites as applicable) to determine eligibility for randomization within 4 weeks prior to randomization (hereafter referred to as the \eligibility scan\)
Appropriate stage for protocol entry, including no distant metastases, based upon the following minimum diagnostic workup:\r\n* History/physical examination, including recording of pulse, blood pressure (BP), weight, and body surface area, within 45 days prior to registration\r\n* Whole body fludeoxyglucose-positron emission tomography (FDG-PET)/CT (orbits to mid-thighs) within 30 days prior to registration; PET/CT must be negative for distant metastasis\r\n* CT scan with contrast of the chest and upper abdomen to include liver and adrenals (unless medically contraindicated) within 30 days prior to registration\r\n* Magnetic resonance imaging (MRI) of the brain with contrast (or CT scan with contrast, if MRI medically contraindicated) within 30 days prior to registration
No evidence of disease outside the breast or chest wall, except ipsilateral axillary lymph nodes on staging scans (computed tomography [CT] chest/abdomen/pelvis and bone scan or positron emission tomography [PET] scan)
No evidence of metastatic disease as determined by chest computed tomography (CT) scan, and abdominal CT scan (or magnetic resonance imaging [MRI] with gadolinium and/or manganese); all patients must be staged with a physical exam, chest CT, abdominal CT with intravenous contrast (or abdominal MRI with gadolinium and/or manganese)
All patients must have their disease status documented by a complete physical examination and imaging studies within 4 weeks prior to the first dose of study drug. Imaging studies must include computerized tomography (CT) scan of neck, chest, abdomen, pelvis, and all known sites of resected disease in the setting of Stage IIIb/c or Stage IV disease, and brain magnetic resonance imaging ([MRI], brain CT allowable if MRI is contraindicated).
Patients must have a diagnostic quality contrast computed tomography (CT) scan of the chest, abdomen and pelvis OR baseline positron emission tomography (PET)-CT scan performed within 28 days prior to registration
Stage clinical T1 N0 M0 or T2 N0 M0 as per American Joint Committee on Cancer (AJCC) Staging system 7th edition, based on the following criteria:\r\n* Chest computed tomography (CT) with upper abdomen to include the liver and adrenal glands with intravenous (IV) contrast (unless medically contraindicated) within 2 months of registration\r\n* Participants must have measurable disease, defined as >= 5 mm on a diagnostic CT scan with slice thickness of no more than 2.5 mm\r\n* Positron emission tomography (PET)/CT scan including neck, chest, abdomen, pelvis within 2 months of study enrollment characterizing the primary tumor and documenting the absence of nodal and distant metastasis\r\n* Brain magnetic resonance imaging (MRI) with gadolinium within 2 months of study enrollment demonstrating the absence of brain metastasis; if an MRI is medically contraindicated or if the patient refuses, a head CT with IV contrast is acceptable
Post-operative computed tomography (CT) scan of the chest, abdomen, and pelvis =< 30 days prior to registration demonstrating no evidence of residual or recurrent malignancy
No evidence of cancer within 28 days prior to start of study treatment; this should be determined by imaging of the chest, abdomen and pelvis by computed tomography (CT) and/or magnetic resonance imaging (MRI); staging of the chest using chest x-ray in lieu of CT and/or MRI should not be used for this purpose
CT scan chest, abdomen and pelvis or positron emission tomography (PET)/CT scan (diagnostic quality CT) performed within 28 days of study registration; for disease outside the brain, tumors must be > 10 mm by CT scan
Radiographic evidence of radiation pneumonitis on a computed tomography (CT) scan of the chest with or without contrast
Patients must have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1; contrast-enhanced computed tomography (CT) scans of the neck, chest, abdomen and pelvis are required; a whole body positron emission tomography (PET)/CT scan with diagnostic quality images and intravenous iodinated contrast may be used in lieu of a contrast enhanced CT of the chest, abdomen and pelvis; imaging of the head and neck is required only if the patient has a head/neck primary; contrast may be omitted if the treating investigator believes that exposure to contrast poses an excessive risk to the patient; if skin lesions are being followed as measurable disease, photograph with a ruler included and physician measurements, must be kept in the patients chart as source documentation; all measurable lesions must be assessed within 28 days prior to registration; tests to assess non-measurable disease must be performed within 42 days prior to registration; all disease must be assessed and documented on the baseline tumor assessment form (RECIST 1.1)
Chest radiograph or computed tomography (CT) scan within =< 3 months prior to study enrollment rules out primary or metastatic malignancy in the lungs or pleural space as a significant cause of respiratory insufficiency
Uncontrolled infections, defined as positive blood cultures within 72 hours of study entry, or evidence of progressive infection by imaging studies such as chest computed tomography (CT) scan within 14 days of registration
No evidence of any lymph node spread or distant metastases as determined by positron emission tomography (PET) computed tomography (CT) imaging within 16 weeks of enrollment; alternatively, for those without PET CT capability, a magnetic resonance imaging (MRI) or CT of the abdomen and pelvis and a chest x-ray confirming no evidence of metastatic disease is acceptable
Radiologic confirmation of the absence of hematogenous metastasis within 12 weeks prior to registration; at a minimum, chest x-ray is required; CT imaging of the chest or PET/CT is acceptable
Patients must have had a contrast-enhanced computerized tomographic (CT) scan of the chest and abdomen within 2 months of study entry and be willing to have a follow up scan within 2 months of the completion of the retreat
Subjects must have had a negative bone scan, and computed tomography (CT) of abdomen and pelvis within 16 weeks prior to registration; additional forms of imaging (Prostascint scan, magnetic resonance imaging [MRI]) may be substituted for a CT scan of the abdomen and pelvis if clinically indicated
Conventional chest abdomen and pelvis CT images demonstrating recurrent tumor must be submitted within 21 days from acquisition to the American College of Radiology (ACR) Core Lab
Patients scheduled and approved for contrast enhanced CT that includes imaging of the abdomen and pelvis following the Department of Radiology standard of care protocol
Subjects must have a computed tomography (CT) scan of the chest within 8 weeks of surgery
Patients will have undergone or have agreed to undergo standard of care CT of the chest, abdomen, and pelvis; 18F-FSPG PET imaging will be performed as investigational studies
Have undergone or agree to undergo standard of care imaging for ovarian cancer with CT chest, abdomen, and pelvis
Completed staging evaluation with bone scan as well as CT or magnetic resonance imaging (MRI) of the abdomen and pelvis at least 45 days prior to study enrollment
Patients with endobronchial involvement seen on chest CT
Baseline imaging to rule out distant metastatic disease (technetium Tc 99m [99mTc] bone scan, sodium fluoride [NaF] PET, total body MRI, or computed tomography [CT] chest/abdomen/pelvis)
Negative or equivocal findings on standard-of-care imaging for restaging of disease in the previous 60 days consisting of: Whole-body 99mTc bone scintigraphy or NaF PET-CT; and either CT or MRI of the pelvis (or the abdomen and pelvis).
Had a chest computed tomography (CT) scan within the past 18 months prior to enrollment
Computed tomography (CT) scan or magnetic resonance imaging (MRI) of the chest, abdomen, and pelvis within 28 days of Cycle 1 Day 1.