[c09aa8]: / clusters / ordered9kclusters / clust_2198.txt

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Clinical nodal staging of N2 or N3 disease
Pathologic nodal staging of N2b, N2c, or N3 disease
Patients must have one or more of the following characteristics and be eligible for breast or chest wall with or without regional nodal radiotherapy:\r\n* Prior chemotherapy for breast cancer\r\n* > 25 cm of breast separation (the largest distance on an axial slice of the planning computed tomography [CT] simulation scan between the entry and exit points of the radiation beam on the body)\r\n* Non-Caucasian race\r\n* Requiring regional nodal irradiation without evidence of N3 disease
Nodal disease as detected by clinical exam or CT
Pathologically confirmed squamous cell carcinoma of the oral cavity; clinical stage >= T2 (primary tumor greater than 2 cm in size) and/or evidence of regional nodal involvement by clinical exam or imaging
Histologic confirmation of breast cancer resected by mastectomy with or without immediate reconstruction and chest wall and regional nodal irradiation planned
Boosts to the chest wall after mastectomy; nodal boosts are allowed
Nodal recurrences can be treated on this protocol but prior curative surgery for lung cancer must have been at least 6 months prior to the nodal recurrence
Diagnosis of selected stage III or IVa/b head and neck squamous cell carcinoma (HNSCC); all patients must have T2-T4 primary tumors (patients with T1 tumors will be excluded); although most of these patients will have regional nodal disease, patients with no nodal disease will also be eligible
ARM 2 - A: Diagnosis of selected stage III or IVa/b HNSCC; all patients must have T2-T4 primary tumors (patients with T1 tumors will be excluded); although most of these patients will have regional nodal disease, patients with no nodal disease will also be eligible
Patient with clinically positive nodal disease
Patients with pathologically proven nodal disease
No evidence of in-transit, nodal or distant metastases as determined by clinical examination, CT or MRI
Symptomatic nodal disease (i.e., scrotal, penile, or leg edema)
Tumor > 2.0 cm, nodal involvement, or metastatic involvement
No clinical or pathologic evidence of nodal involvement
Gross total excision of both primary and nodal disease; this includes tonsillectomy, local excision of primary site, and nodal excision that removes all clinically and radiographically evident disease
Patients who are to undergo definitive chemoradiation must have clinically or radiographically evident measurable disease at the primary site and/or at nodal stations. Tonsillectomy or local excision of the primary without removal of nodal disease is permitted.
Clinical evidence of progression of disease > 20% in the breast or new evidence of nodal metastases
Treatment plan that includes regional nodal irradiation
N3 nodal disease
Invasion or ulceration of inguinal nodal disease into the overlying skin
Prior radiation therapy to the same regional nodal basin
Patients must have metastatic melanoma or stage III in-transit, subcutaneous, or regional nodal disease
Patients are eligible for this trial either at presentation for primary melanoma with concurrent regional nodal and/or in-transit metastasis, or at the time of clinically detected nodal and/or in-transit recurrence and may belong to any of the following groups:\r\n* Primary melanoma with clinically apparent (overt) regional lymph node metastases\r\n* Clinically detected recurrence of melanoma at the proximal regional lymph node(s) basin\r\n* Clinically detected primary melanoma involving multiple regional nodal groups\r\n* Clinically detected single site of nodal metastatic melanoma arising from an unknown primary\r\n* Patients with intransit or satellite metastases with or without lymph node involvement are allowed if they are considered potentially surgically resectable at baseline\r\n** NOTE: a patient should be determined to be potentially surgically resectable at baseline to be eligible for this neoadjuvant study
Evidence of nodal involvement identified in the operating room (OR)
Patients must have metastatic melanoma or stage III in-transit, subcutaneous, or regional nodal disease (Turnstile I)
No gross vascular invasion or regional nodal or distant metastases
The presence of cervical conglomerate nodal mass or extracapsular spread (ECS) on imaging
Patients must have metastatic melanoma or stage III in-transit, subcutaneous, or regional nodal disease (Turnstile I)
Patients must have histologically confirmed (by routine hematoxylin [H] & eosin [E] staining) adenocarcinoma of the breast with confirmed nodal metastasis; patients must have an axillary nodal evaluation by fine-needle aspiration (FNA), sentinel node biopsy (SNB) or nodal dissection; patients with triple negative breast cancer are eligible as long as they are node negative; patients with squamous, or metaplastic carcinomas or sarcomas of the breast are NOT eligible
Patient must have > 1.0 cm residual in-breast cancer and/or clinically positive residual nodal disease
Treatment plan that includes regional nodal irradiation
Patients whose only nodal disease is cystic and not PET-avid
Patients must have measurable disease as per appropriate guidelines:\r\n* Solid tumors: by RECIST v1.1\r\n* Lymphoma: patient has at least one measurable nodal lesion (>= 2 cm) according to Lugano classification; if the patient has no measurable nodal lesions >= 2 cm in the long axis at screening, then the patient must have at least one measurable extra-nodal lesion
Patient has known nodal or distant metastatic disease; patients with nodal or metastatic disease require systemic chemotherapy; furthermore, they should be excluded from this clinical trial because of their poor overall prognosis
Patients must have clinically or radiographically evident measurable disease at the primary site or at nodal stations; tonsillectomy or local excision of the primary without removal of nodal disease is permitted, as is excision removing gross nodal disease but with intact primary site; limited neck dissections retrieving =< 4 nodes are permitted and considered as non-therapeutic nodal excisions
Pathologic assessment of the mediastinum to document involved nodal stations
Patients with para-aortic nodal disease or who require extended field radiotherapy beyond the pelvis
Subjects must have measurable disease and be a candidate for intralesional therapy administration into cutaneous, subcutaneous, or nodal lesions.
Patients are eligible for this trial either at initial presentation of their melanoma or at the time of the first detected nodal, satellite/in-transit, distant metastases, or recurrent disease in prior lymphadenectomy basin or distant site; nodal, satellite/in-transit metastasis, distant metastases or disease in a prior complete lymphadenectomy basin must have been confirmed histologically by hematoxylin and eosin (H & E) stained slides
Patients with multiple regional nodal basin involvement are eligible; gross or microscopic extracapsular nodal extension is permitted
Residual invasive disease post-neoadjuvant either in the breast or as residual nodal invasion.
at least 1 injectable cutaneous, subcutaneous, or nodal melanoma lesion ? 5 mm in longest diameter
Histologic diagnosis of melanoma with metastatic disease to a visceral organ (lung, liver, brain, adrenal, nodal station outside the regional lymph drainage of the primary, vertebral bodies)
Evidence of positive nodal disease (stage N1)
Extrahepatic metastases including nodal disease
Patients with metastatic disease involving viscera or bones are ineligible; patients with extensive nodal involvement alone classified as stage IV disease, are eligible
Patient's disease must show extracapsular spread (ECS) in their nodal metastasis
Measurable nodal disease by computed tomography
Patients are eligible for this trial either at presentation for primary melanoma with concurrent regional nodal and/or in-transit metastasis, or at the time of clinically detected nodal and/or in-transit recurrence; patients must undergo biopsy (punch) or open biopsy (if done as part of a clinically indicated baseline diagnostic procedure) within 14 days of entry into the study; lymphadenectomy/definitive surgery will be performed after at least 2 and generally not longer than 4 weeks of induction HDI-ipilimumab therapy; additional delays for definitive lymphadenectomy/surgery are allowed if clinically indicated while awaiting the resolution of potential adverse events from HDI-ipilimumab therapy
Untreated N3 mediastinal nodal disease
Any evidence of nodal positivity beyond pathologic stage of pN0(i+)
Patients with nodal involvement are eligible
Stage 1-3 tumors > 1 cm in maximal diameter, any nodal status, multifocal or multi-centric disease is permitted, no evidence of distant metastases
Subjects with negative nodal status (N0)
Patients with nodal disease are eligible
Known N2 nodal disease or distant metastatic disease
Previously treated, histologically confirmed cluster of differentiation (CD)20+ B cell lymphoma; bone marrow biopsies as the sole means of diagnosis are not acceptable, but they may be submitted in conjunction with nodal biopsies or extra nodal biopsies; fine needle aspirates are not acceptable
Patient has at least one measurable nodal lesion (?2 cm) according to Cheson criteria (Cheson 2007). In case where the patient has no measurable nodal lesions ? 2 cm in the long axis at baseline, then the patient must have at least one measurable extra-nodal lesion.
Presence of active nodal metastases (e.g., radiologic or clinical evidence of current nodal disease)
Patients treated by BCS or mastectomy and axillary dissection must have 1-3 positive axillary nodes (macrometastases, > 2 mm)\r\n* Note patients with additional nodal micrometastases (> 0.2-2 mm) or isolated tumor cells (=< 0.2 mm) are eligible; patients with nodal disease limited only to micrometastases or isolated tumor cells are not eligible
Patients treated by BCS and sentinel lymph node biopsy (SLNB) alone must have only 1-2 positive axillary nodes (macrometastases, > 2 mm)\r\n* Note patients with additional nodal micrometastases (> 0.2-2 mm) or isolated tumor cells (=< 0.2 mm) are eligible; patients with nodal disease limited only to micrometastases or isolated tumor cells are not eligible
Patients treated by mastectomy and SLNB alone must have only 1 positive axillary node (macrometastases, > 2 mm)\r\n* Note patients with additional nodal micrometastases (> 0.2-2 mm) or isolated tumor cells (=< 0.2 mm) are eligible; patients with nodal disease limited only to micrometastases or isolated tumor cells are not eligible
Patients must have measurable disease; must have at least one non-nodal lesion
Nodal disease as detected by clinical exam or CT
Symptomatic nodal disease, i.e. scrotal, penile or leg edema
Regional nodal irradiation is part of the treatment plan
No clinical or radiological evidence of hematogenous or distant nodal (retroperitoneal, pelvic, mediastinal, peri-portal or peri-aortic) metastasis
Indications for comprehensive regional nodal irradiation
Patients with local or regional nodal disease are eligible
Clinical stage > T2b or evidence of nodal
Patients with local or regional nodal disease are eligible
Patients with nodal disease or distant metastatic disease
Subjects will have had standard care computed tomography (CT), MRI, or ultrasound, and a fine-needle aspiration biopsy demonstrating PTC or MTC with nodal metastases or recurrent/persistent nodal disease in a patient with known PTC or MTC
Bulky disease (defined as a nodal mass measuring >= 10 cm by CT)
Mediastinal nodal metastases (N2) disease must be confirmed histologically
Negative nodal basin clinical exam
Subject must be candidate for intralesional therapy administration defined as one or more of the following: i. at least 1 injectable cutaneous, subcutaneous, or nodal SCCHN tumor ? 10 mm in longest diameter ii. multiple injectable cutaneous, subcutaneous, or nodal SCCHN tumors that in aggregate have a longest diameter of ? 10 mm Note: Mucosal surfaces of tumor lesions and visceral metastases should not be injected.
Women without histologic confirmation of nodal involvement