PARTICIPANTS NOT ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Leukocytes >= 2,000/mm^3, within 2 weeks prior to enrollment
PARTICIPANTS NOT ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Absolute neutrophil count >= 1,000/mm^3, within 2 weeks prior to enrollment
PARTICIPANTS NOT ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Platelets >= 75,000/mm^3, within 2 weeks prior to enrollment
PARTICIPANTS NOT ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Hemoglobin >= 9 g/dL, within 2 weeks prior to enrollment
PARTICIPANTS NOT ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Serum albumin >= 2.8 g/dL, within 2 weeks prior to enrollment
PARTICIPANTS ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Leukocyte count: no lower limit, within 2 weeks prior to enrollment
PARTICIPANTS ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Absolute neutrophil count: > 500/mcL, within 2 weeks prior to enrollment
PARTICIPANTS ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Platelets: > 50,000/mcL, within 2 weeks prior to enrollment
PARTICIPANTS ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Hemoglobin: >= 9 g/dL unless bone marrow involvement secondary to Hodgkin lymphoma is present, within 2 weeks prior to enrollment
PARTICIPANTS ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Serum albumin: >= 2.8 g/dL, within 2 weeks prior to enrollment
PARTICIPANTS ON THE HODGKIN LYMPHOMA EXPANSION COHORT: Creatinine: < 1.5 x upper normal limit (UNL) or CrCl > 50ml/min, within 2 weeks prior to enrollment
Hodgkin lymphoma: must have received and failed frontline therapy
Mature B-Cell non-Hodgkin Lymphoma that is Relapsed/Refractory to standard therapy
NON-HODGKIN LYMPHOMA INCLUSION CRITERIA:
Patients with histologically/cytologically confirmed solid tumor, or lymphoma. For the expansion cohort, only patients with peripheral/cutaneous T cell lymphoma, Hodgkin's lymphoma, and other non-Hodgkin's lymphoma would be considered eligible
PHASE II: CD19+ non-Hodgkin lymphoma (NHL) refractory or relapsed with no known curative therapies available
Patients must have histologically confirmed relapsed or refractory non-Hodgkin's lymphoma or Hodgkin's disease (World Health Organization [WHO] criteria) (Phase I)
Untreated cutaneous T-Cell non-Hodgkin lymphoma (CTCL) (with the exception of untreated tumor stage Mycosis fungoides)
Histopathologically-confirmed diagnosis of classical Hodgkin lymphoma
At least 90 days have elapsed since bone marrow transplant and participant is off immune suppression for >= 2 weeks, if applicable; participants with ALL or non-Hodgkin lymphoma (NHL) who were transplanted in first remission are eligible for this study
Presence of measurable disease defined per the 2008 International workshop on CLL guidelines, or by 2014 Lugano criteria for non-Hodgkin lymphoma
Indolent NHL or Hodgkin lymphoma with POD after most recent salvage chemotherapy.
Any B-cell non-Hodgkin lymphoma would be eligible for phase I portion of the study
Undergoing autologous stem cell transplant for one of the following diagnoses:\r\n* Multiple myeloma\r\n* Non-Hodgkin lymphoma
Hodgkin lymphoma – must have received and failed frontline therapy
Patients with histologically proven Hodgkin lymphoma (HL) will be eligible for transplantation after failing prior therapy
For NHL, detectable PET-positive disease according to the “Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification”
Active CNS involvement of non-Hodgkin lymphoma (NHL)
Patients must have a histopathologically confirmed diagnosis of an aggressive B-cell non-Hodgkin lymphoma that is recurrent or refractory to standard therapy
B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma (grey-zone lymphoma)
Classic Hodgkin Lymphoma (cHL), relapsed or refractory
Patients must have histologically documented or cytologically confirmed Hodgkin lymphoma; confirmation must include CD30 expression
Must not have had second line chemotherapy for Hodgkin lymphoma
Patients must have histologically documented or cytologically confirmed Hodgkin lymphoma with CD30 expression
There must be histological confirmation of relapse after alloSCT of any of the following diseases: any mature B cell lymphoma (classical Hodgkin lymphoma [cHL] or non-Hodgkin lymphoma [NHL]), acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)
Relapsed Hodgkin's disease or non-Hodgkin's lymphoma (NHL)
Hodgkin lymphoma:\r\n* Relapsed disease with progression after autologous bone marrow transplant or are ineligible for this procedure\r\n* Responding to therapy prior to enrollment
Non-Hodgkin lymphoma:\r\n* Responding to therapy prior to enrollment; \r\n* Progression after autologous bone marrow transplant or are ineligible for this procedure
PHASE I: Patients with relapsed or refractory Hodgkin lymphoma or non-Hodgkin lymphoma; patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are also eligible; in addition, patients with NHL other than diffuse large B cell lymphomas (DLBCL) must have received at least 2 prior therapies; patients with DLBCL and Hodgkin lymphoma (HL) will be eligible if there is no available standard therapy
Patients must have histologically documented or cytologically confirmed Hodgkin lymphoma with CD30 expression
Prior ibrutinib for Hodgkin lymphoma is not allowed
Large-cell lymphoma, Hodgkin lymphoma and multiple myeloma with chemotherapy sensitive disease who are ineligible for an autologous transplant
Histologically confirmed diagnosis of Indolent non-Hodgkin's lymphoma (iNHL) in CD20 positive patients, with histological subtype limited to:
Previously untreated non-Hodgkin lymphoma or Hodgkin lymphoma; all stages of disease are allowed; also eligible are patients who have started or completed one or more cycles of treatment as part of a planned first line regimen, or those who have received local radiation or surgery or corticosteroids for disease control
Planned treatment with standard first line therapy for non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL)
Patients must have histologically confirmed transformed indolent B-cell non-Hodgkin lymphoma that is relapsed or refractory to at least one line of therapy
Relapsed or refractory lymphoid malignancies (including non-Hodgkin lymphoma, Hodgkin lymphoma and chronic lymphocytic leukemia) meeting the following criteria:\r\n* Disease status: stable disease, partial remission or 2nd and 3rd complete remission
Patients with refractory B-cell or T-cell non-Hodgkin's lymphoma or Hodgkin's lymphoma who are eligible for allogeneic transplantation
Recipients of first/second ASCT for the treatment of hematologic malignancies (multiple myeloma, Hodgkin's and non Hodgkin's lymphoma)
History of relapsed or refractory CD19+ malignancies (e.g. non Hodgkin lymphoma) who have failed prior treatment and require autologous hematopoietic stem cell transplant; evidence of disease not required (cohort 2)
Histologic diagnosis of classical CD30 positive Hodgkin lymphoma confirmed at enrolling institution
Lymphoma: patients with \r\n* Diagnosis of non-Hodgkin lymphoma (NHL) or Hodgkin's lymphoma (HL), of any histological grade\r\n* Refractory or relapsed disease after standard chemotherapy\r\n* High risk of early relapse following autograft alone
Hodgkin disease: Must have received and failed frontline therapy
Large-cell lymphoma, Hodgkin lymphoma and multiple myeloma with chemotherapy sensitive disease that has failed or patients who are ineligible for an autologous transplant
Non-Hodgkin's lymphomas in the following categories: mediastinal gray zone lymphoma and primary mediastinal B cell lymphoma
Histologically proven within the last 6 months of relapsed or refractory\r\n* Non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL) nodal or extranodal OR\r\n* Cutaneous T-cell lymphoma (CTCL) including mycosis fungoides (MF), as well as transformed MF OR\r\n* Breast adenocarcinoma with nodal or cutaneous metastases (stage 4)\r\n** NOTE: Patients must be refractory to or intolerant of existing therapy(ies) known to provide clinical benefit for their condition\r\n** NOTE: The patient must not be a candidate for any curative therapy or any known life-prolonging therapy
Phase 1b only: B-cell non-Hodgkin's lymphoma (NHL), relapsed or refractory to standard approved therapies
Classical Hodgkin lymphoma determined by local hematopathology review
Have had prior chemotherapy or radiotherapy for Hodgkin lymphoma
Non-Hodgkin lymphoma with poor risk features not suitable for autologous HCT
Patients must have histologically documented (confirmed at the Laboratory of Pathology, National Cancer Institute [NCI]), relapsed solid tumor malignancy or Hodgkin's disease/non-Hodgkin lymphoma that is metastatic or unresectable for which standard curative measures do not exist, or are associated with minimal patient survival benefit
B-cell non-Hodgkin lymphoma involving the brain, as demonstrated by contrast-enhanced magnetic resonance imaging (MRI) and histologic confirmation by one of the following within 6 weeks prior to registration:             \r\n* A positive cerebral spinal fluid (CSF) cytology for lymphoma or a monoclonal lymphocyte population as defined by cell surface markers\r\n* A biopsy of the vitreous or uvea demonstrating non-Hodgkin lymphoma\r\n* Brain biopsy \r\n* NOTE: patients in whom the type of lymphoma could not be determined or is unknown (e.g., not enough tissue for further analysis) are assumed to have a B-cell lymphoma and are eligible
Hodgkin and non-Hodgkin lymphoma (all types, including mantle cell lymphoma)\r\n* Primary treatment failure\r\n* Relapse after autologous stem cell transplant (SCT)\r\n* Non-CR after salvage regimen
Diagnosis of CD30+ classical Hodgkin lymphoma reconfirmed by histopathology. Note: where reconfirmation is not possible, patients will still be eligible where they have confirmation clearly documented in their medical records.
Relapsed or refractory Hodgkin lymphoma following failure of standard frontline chemotherapy for the treatment of classical Hodgkin lymphoma
AIDS-related non-Hodgkin lymphoma and other non-Hodgkin lymphoma\r\n* Failed standard first-line therapy; and\r\n* Failed autologous stem cell transplant if indicated for histology (i.e diffuse large B-cell lymphoma) or autologous stem cell transplant is not feasible
Subjects with any previously treated advanced (metastatic or refractory) solid tumor type and B-cell non-Hodgkin lymphoma
Subjects must have a previously treated advanced solid tumor or B cell non-Hodgkin's lymphoma to be eligible
Phase I (Cohort T): Participants with non-Hodgkin's lymphoma, regardless of PIK3CA mutation status
non-Hodgkin lymphoma
Pediatric solid tumor (including Hodgkin's and Non-Hodgkin's lymphoma), for which prior treatment had proven to be ineffective (that is, relapsed or refractory) or intolerable
Newly diagnosed and previously untreated classical Hodgkin Lymphoma (cohort D)
Histologically confirmed diagnosis of a non-Hodgkin or Hodgkin lymphoma that has progressed in spite of prior treatment, and for which additional effective standard therapy is not available
Histological evidence of transformation of FL into high-grade B-cell non-Hodgkin's lymphoma (NHL)
Histologically confirmed B-cell non-Hodgkin's lymphoma that has relapsed after or failed to respond to at least one prior treatment regimen and for which no suitable therapy of curative intent or higher priority exists
Patients must have histologically confirmed CD30 positive relapsed or refractory Hodgkin lymphoma
Patient with Hodgkin's lymphoma with relapsed or refractory disease who are not eligible for stem cell transplantation or other standard therapies
Indolent / aggressive B-cell non-Hodgkin's lymphoma (NHL)
Hodgkin's lymphoma (HL)
Histologically confirmed classical Hodgkin Lymphoma (HL)
Any patient, regardless of age or sex, with one or more of the following EBV-positive or associated disorders, regardless of the histological subtype:\r\n* Hodgkin lymphoma\r\n* Non-Hodgkin lymphoma\r\n* Lymphoproliferative disorder\r\n* Nasopharyngeal carcinoma\r\n* Leiomyosarcoma\r\n* Severe chronic active EBV infection syndrome (SCAEBV), defined as high EBV viral load in plasma or peripheral blood mononuclear cell (PBMC) (> 4000 genomes per ug PBMC deoxyribonucleic acid [DNA]) and/or biopsy tissue positive for EBV
Any patients, regardless of age or sex, with one or more of the following EBV-positive or associated disorders, regardless of the histological subtype:\r\n* Hodgkin lymphoma\r\n* Non-Hodgkin lymphoma\r\n* Lymphoproliferative disorder\r\n* Nasopharyngeal carcinoma\r\n* Leiomyosarcoma\r\n* Severe chronic active EBV infection syndrome (SCAEBV), defined as high EBV viral load in plasma or PBMC (> 4000 genomes per Mg PBMC DNA) and/or biopsy tissue positive EBV
Relapsed or refractory de novo classical Hodgkin lymphoma
Patients must have at least one bi-dimensionally measurable lesion (which has not been previously irradiated) according to the Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification.
Confirmed diagnosis of Hodgkin's Lymphoma
Phase I: Patients must have histologically confirmed relapsed or refractory non-Hodgkin lymphoma or Hodgkin lymphoma (World Health Organization [WHO] criteria), with no accepted curative options
Diagnosed or treated for malignancy other than indolent Non-Hodgkin lymphoma
Has received prior therapy for Hodgkin lymphoma, except as noted
Histopathological diagnosis of classical Hodgkin lymphoma
Histologically confirmed relapsed or refractory Hodgkin lymphoma (HL) or anaplastic large cell lymphoma (ALCL)
A concurrent diagnosis of systemic ALCL, or other non Hodgkin lymphoma (excluding LyP) or Sezary syndrome or B2 disease
Patients with non-Hodgkin lymphoma (NHL) other than MCL
Patients must have no evidence or history of non-Hodgkin lymphoma (NHL) outside of CNS
Patients must not have received prior chemotherapy or radiation therapy for the treatment of Hodgkin lymphoma
Hodgkin Lymphoma beyond first remission achieving at least a partial response to most recent therapy with no evidence of progression prior to transplant.
Non-Hodgkin Lymphoma beyond first remission achieving at least a partial response to most recent therapy with no evidence of progression prior to transplant.
Patient must have histologically documented classical Hodgkin lymphoma that was recurrent or refractory to standard chemotherapy
Hodgkin lymphoma patients must have received at least 2 prior regimens and received, declined, or be ineligible for autologous transplant
Patient has histologically confirmed diagnosis of Hodgkin lymphoma
Previously treated or refractory large B-cell lymphomas, grey-zone lymphoma, Hodgkin lymphoma, including lymphocyte predominant Hodgkin lymphoma (LPHL)
Hodgkin lymphoma – must have received and a) failed frontline therapy, b) not be eligible for autologous HCT, or c) or be part of a tandem auto-allo approach for high risk patients
Other non-Hodgkin lymphoma (NHL) histologies
No evidence of systemic non-Hodgkin's lymphoma.
Tumor type criteria: relapsed/refractory non-Hodgkin's lymphoma (NHL) that meets one of the following criteria:
Have biopsy-confirmed non-Hodgkin lymphoma, of any type
Have evidence of progressive non-Hodgkin lymphoma
Patients with relapsed/refractory lymphoma (B cell non-Hodgkin) who have lack of objective response to at least two prior chemotherapy regimens
Plasma cell myeloma and Hodgkin lymphoma are excluded
Patients with confirmed CD30-positive DLBCL or grade 3b follicular non-Hodgkin lymphoma (NHL).
Participants with Hodgkin or Non-Hodgkin lymphoma must meet one of the following criteria:\r\n* Relapsing disease in 2nd or greater relapse and measurable disease, or\r\n* Refractory disease failing to achieve complete response (CR) with >= 2 induction or re-induction attempts
Patient must have relapsed or refractory non-Hodgkin's lymphoma (NHL) or Hodgkin's disease. Patients must have CNS 1 disease. Patient must have histologic verification of disease at original diagnosis. Patient must have measurable disease documented by clinical or radiographic criteria or bone marrow disease present at study entry.
Prior HSCT for Hodgkin's Lymphoma: Patients with Hodgkin's lymphoma must have had prior attempt at autologous HSCT.
Diagnosis of multiple myeloma or non-Hodgkin lymphoma
Diagnosis of Hodgkin lymphoma or non-Hodgkin lymphoma
Chronic lymphocytic leukemia, Hodgkin lymphoma, and non-Hodgkin lymphoma are excluded
Histologically confirmed, previously untreated Hodgkin lymphoma
Non-Hodgkin's lymphoma (NHL) or Hodgkin's disease (HD) in 2nd or greater complete remission, partial remission
Patients must have histologically documented or cytologically confirmed Hodgkin lymphoma with CD 30 expression
Chemotherapy-sensitive relapsed lymphoma (complete or partial response), Hodgkin or non-Hodgkin lymphoma, no evidence of \bulky\ disease (> 10 cm in diameter)
Diagnosis of AML, Multiple myeloma, Hodgkin's or Non-Hodgkin's lymphoma for whom standard curative or palliative measures do not exist or are no longer effective
Diagnosis of leukemia, non-Hodgkin's lymphoma, Hodgkin's disease or other hematologic malignancy.
T-cell non-Hodgkin's lymphoma (T-NHL) with one of the following: \r\n* Primary refractory (=< CR to 1st line or relapse within 6 months); or\r\n* Nonresponsive (SD/PD) to >= 1 line of salvage
Histologic confirmation of classical Hodgkin lymphoma after imaging documenting primary refractory or relapsed disease
Received > 1 line of therapy for Hodgkin lymphoma
Histologic diagnosis of classical Hodgkin lymphoma
Participants must have histologically or cytologically confirmed multiple myeloma, or non-Hodgkin lymphoma and must be undergoing melphalan conditioning for autologous HSCT
Previously untreated stage IA, IB, IIA or IIB classical Hodgkin lymphoma
Large-cell lymphoma, Hodgkin lymphoma and multiple myeloma with chemotherapy sensitive disease that has failed or patients who are ineligible for an autologous transplant
Hodgkin lymphoma beyond CR1 with chemosensitive disease, stable disease (SD) may be included if no mass > 3 cm
Hodgkin and non-Hodgkin lymphoma: must have a complete or partial response with prior therapy
Diagnosis of recurrent Hodgkin's lymphoma (HL) with a treatment plan that will include high dose chemotherapy with/without total body irradiation and autologous cell transplantation
Hodgkin lymphoma – must have received and failed frontline therapy
Large-cell lymphoma, Hodgkin lymphoma and multiple myeloma with chemotherapy sensitive disease that has failed or patients who are ineligible for an autologous transplant
Any malignancy metastatic to other organ, excluding Hodgkin’s or non-Hodgkin's lymphoma
Lymphoma (including Hodgkin's)
History of histologically confirmed non-Hodgkin lymphoma (NHL) as assessed per medical record review
Clinically stable patients undergoing I-131 tositumomab (Bexxar) or Y-90 ibritumomab tiuxetan (Zevalin) for treatment of non-Hodgkin lymphoma
Previously untreated stage I or II non-bulky (defined as a mass measuring < 10 cm in the longest dimension by CT) Hodgkin lymphoma
EBV-positive or KSHV-associated malignancy, including but not limited to:\r\n* EBV+ Hodgkin lymphoma\r\n* EBV+ non-Hodgkin lymphoma or lymphoproliferative disease\r\n* Primary effusion lymphoma\r\n* Kaposi's sarcoma\r\n* EBV+ gastric cancer\r\n* EBV+ nasopharyngeal cancer
Diagnosis of leukemia, non-Hodgkin's lymphoma, Hodgkin's disease, or other hematologic malignancy.