History of non-pharmacologically induced prolonged QTc interval
Prolonged rate corrected QT (QTc) interval < 500 msec
Patients with a pre-existing diagnosis of a prolonged QT syndrome (even if corrected QT interval [QTc] is normal at the time of APL diagnosis) are excluded
QTc =< 480 msec; Note: Patients with grade 1 prolonged QTc (450- 480 msec) at the time of study enrollment should have correctable causes of prolonged QTc addressed if possible (i.e., electrolytes, medications)
Patients must not have a history of clinically significant arrhythmia, prolonged corrected QT (QTc) interval, or unexplained syncope not thought to be vasovagal in nature within 6 months prior to registration
Prolonged corrected QT (QTc) interval > 500 msec, calculated according to Fridericia's formula
History of prolonged QTc interval.
Prolonged corrected QT (QTc) interval
Prolonged baseline QTc
Subjects with prolonged corrected QT (QTc) (> 450 msec) will be excluded from the study.
Corrected QT (QTc) interval using Fridericia’s formula (QTcF) >= 450 msec. Bundle branch block and prolonged QTc interval are permitted after discussion with the PI.
Prolonged rate corrected QT (QTc) interval ? 500 msec, calculated according to institutional guidelines
Prolonged rate corrected QT (QTc) interval >= 500 msec, calculated according to institutional guidelines
Unstable or serious concurrent medical conditions in the previous 6 months, eg, pancreatitis, severe/unstable angina, prolonged QT interval corrected by Fridericia’s formula (QTcF) > 470 msec (calculated as average of triplicate readings, taken no greater than 2 minutes apart, and no history of torsades de pointes or symptomatic corrected QT [QTc] abnormality), symptomatic congestive heart failure, myocardial infarction and/or pulmonary hypertension, ongoing maintenance therapy for life-threatening ventricular arrhythmia, stroke, and uncontrolled major seizure disorder
Prolonged rate corrected QT (QTc) interval of > 500 msec, calculated according to institutional guidelines
Adequate cardiac function defined as\r\n* No history of congenital QTc syndrome, New York Heart Association (NYHA) class III or IV congestive heart failure (CHF)\r\n* No clinical significant cardiac arrhythmias, stroke or myocardial infarction within 6 months prior to enrollment\r\n* QTc =< 480 msec; Note: Three electrocardiograms (ECGs) must be performed for eligibility determination; if the average of these three consecutive results for corrected QT using Fridericia's formula (QTcF) is =< 480 msec, the subject meets eligibility in this regard; patients with grade 1 prolonged QTc (450-480 msec) at the time of study enrollment should have correctable causes of prolonged QTc addressed if possible (i.e. electrolytes, medications)
No history of prolonged QTC or cardiomyopathy unless normal QTC and ejection fraction confirmed within 1 month prior to study entry
Prolonged corrected QT (QTc) interval on pre-entry electrocardiogram (>= 450 msec)
A clinically significant ECG abnormality, including a marked baseline prolonged QT or QTc interval (eg, a repeated demonstration of a QTc interval greater than 480 msec).
Patients with known prolonged corrected QT (QTc) syndrome or prolonged QTc syndrome noted on baseline electrocardiography (ECG)
Prolonged rate corrected QT (QTc) interval >= 500 msec, calculated according to institutional guidelines
At increased risk for developing prolonged QT interval unless corrected to within normal limits prior to first dose of SNX-5422
At increased risk for developing prolonged QT interval unless corrected to within normal limits prior to first dose of SNX-5422
History of non-pharmacologically induced prolonged QTc interval >480 milliseconds.
History of cardiac disease (arrhythmia, conduction abnormality, congenital prolonged QT syndrome, or prolonged corrected QT [QTc] rhythm noted during initial electrocardiogram [EKG] > 480 ms)
Documented history of prolonged QTc interval =< 6 months prior to registration
Clinically significant active cardiovascular disease or history of prolonged QT interval corrected for heart rate (QTc)
Corrected QT (QTc) =< 480 msec\r\n* Note: patients with grade 1 prolonged QTc (450-480 msec) at the time of study enrollment should have correctable causes of prolonged QTc addressed if possible (i.e. electrolytes, medications)
Prolonged corrected QT interval (QTc) on pre-entry electrocardiogram (> 470 msec for men and > 480 msec for women per American Heart Association (AHA)/American College of Cardiology (ACC) 2011 scientific statement
A prolonged QTc of >= 480 ms interval on electrocardiogram
Patients with a history of prolonged corrected QT (QTc) syndrome
Patients with a known history of a prolonged QT interval (corrected QT interval [QTc] > 480) may not be enrolled in this study
Patients may not have any clinically significant cardiovascular disease including the following:\r\n* Myocardial infarction or ventricular tachyarrhythmia within 6 months\r\n* Prolonged corrected QT (QTc) > 480 msec (Fridericia correction)\r\n* Known ejection faction less than institutional normal\r\n* Major conduction abnormality (unless a cardiac pacemaker is present)
Documentation of the patient’s history of corrected QT interval (QTc) prolongation, family history of prolonged QTc, and relevant cardiac disease within 10 days prior to registration
Prolonged corrected QT interval (QTC) on electrocardiogram (EKG)
Prolonged QTC
Has clinically active heart disease including prolonged corrected QT interval
Patients with a left ventricular cardiac ejection fraction < 50% as assessed by an echocardiogram or MUGA scan or prolonged QTc interval of Grade 2 or higher or history of prolonged QTc interval from other drugs.
Prolonged corrected QT (QTc) interval on pre-entry electrocardiogram (> 450 msec) within 30 days prior to study registration
Patients with a baseline QTc > 500 msec and patients with a family history of prolonged QT syndrome
Participants with a history of congenitally prolonged corrected QT interval (QTc), a first degree relative with unexplained sudden death under 40 years of age, or a measured QTcB (Bazett’s correction) longer than 480 msec on electrocardiogram (ECG); ECGs should be performed after correction of electrolyte abnormalities; participants with a prolonged QTcB should have a repeat ECG twice, at least 24 hour apart, and the average of the 3 QTcBs should not exceed 480 msec; history of QT prolongation associated with other medications that required discontinuation of that medication
Prolonged rate corrected QT (QTc) interval >= 500 msec, calculated according to institutional guidelines
Prolonged QTc interval on pre-entry electrocardiogram (>/= 450 msec)
Prolonged corrected QT (QTc) interval (>= 500 msec), as calculated by Bazett's formula
Patients must not have a prolonged PR interval (defined as > 200 ms).
History of significant cardiovascular disease, defined as:\r\n* Congestive heart failure greater than New York Heart Association (NYHA) class III according to the NYHA functional classification \r\n* Unstable angina or myocardial infarction within 6 months of enrollment\r\n* Serious cardiac arrhythmia\r\n* A prolonged QT/corrected QT (QTc) interval (QTc > 500 ms) demonstrated on electrocardiogram (ECG) at screening or baseline; a history of risk factors for torsade de pointes (e.g., heart failure, hypokalemia, family history of long QT syndrome) or the use of concomitant medications that prolonged the QT/QTc interval
Prolonged QTc interval on pre-entry electrocardiogram (> 470 msec)
Clinically active heart disease including prolonged QTc or prolonged PR interval, or history of arrhythmias
Prolonged rate corrected QT interval (QTc) >=500 millisecond (msec), calculated according to institutional guidelines.
Prolonged QTcF
Mean corrected QT (QTc) interval >= 450 (triplicate electrocardiograms [ECGs]) or history congenital prolonged QT interval
Patients may not have any clinically significant cardiovascular disease including the following:\r\n* Myocardial infarction or ventricular tachyarrhythmia within 6 months\r\n* Prolonged corrected QT interval (QTc) > 480 msec\r\n* Ejection fraction less than 50%\r\n* Major conduction abnormality (unless a cardiac pacemaker is present)
Patient with prolonged QT/QTc (defined as QTc interval > 450 msec) are not eligible.
Documented history of prolonged QTc interval =< 6 months prior to registration
Prolonged QTc interval on pre-entry electrocardiogram (> 450 msec) on the Bazett’s correction
Prolonged QTC interval >450ms
Medical disorder that would endanger subject’s well-being (e.g., uncorrected hypothyroidism, cardiac arrhythmia, hypertension requiring treatment, sick sinus syndrome, prolonged corrected QT [QTc])
Diagnosis of narcolepsy, sick sinus syndrome, arrhythmia, or prolonged corrected QT interval (QTc)
Subjects having an electrocardiogram with a prolonged corrected QT (QTc) interval by manual reading: QTc greater than 490 msec
Prolonged QTc interval >450 msec
Prolonged QTc interval defined as greater than 480 ms.
Subjects with prolonged QT interval.