Patients must have corrected QT (QTc) =< 480 msec by electrocardiogram (ECG) (corrected using the Bazett’s formula) within 28 days prior to registration
Corrected QT interval (QTc) < 470 milliseconds (msec) on a 12-lead electrocardiogram (ECG) =< 28 days before registration
Corrected QT interval (QTc) on electrocardiogram (EKG) > 480 msec
Screening electrocardiogram (ECG) with a corrected QT interval (QTc) > 450 msec
Participants must have a corrected QT (QTc) of =< 470 msec for females and =< 450 for males on the screening electrocardiogram (EKG)
Documented within 14 days of registration: Cardiac corrected QT (QTc) interval < 450 msec on electrocardiogram (EKG)
Have a mean QT interval corrected for heart rate (QTc) of ?470 milliseconds on screening electrocardiogram (ECG) as calculated using the Bazett's formula at several consecutive days of assessment.
Subject has corrected QT (QTc) interval < 500 msec on baseline electrocardiogram
Patients who have corrected QT (QTc) interval of > 470 msec on a screening electrocardiogram
QT interval corrected for rate (QTc) > 450 msec on the electrocardiogram (ECG) obtained at Screening
Patients with prolonged corrected QT (QTc) interval (> 450 msec) (for cohort 2a and 2b [belinostat cohorts] only, electrocardiogram [ECG] nor required for cohort 1)
Electrocardiogram (ECG) abnormalities of Q-wave infarction, unless identified 6 or more months prior to screening or QTc Fridericia (F) interval >460 msec
Electrocardiogram (ECG) corrected QT (QTC) < 450 msec
Have QT corrected interval of >450 milliseconds (msec) on screening electrocardiogram (ECG)
Baseline electrocardiogram (EKG) with corrected QT interval (QTc) > 470 msec (including subjects on medication); subjects with ventricular pacemaker for whom QT interval is not measurable will be eligible on a case-by-case basis
Corrected QT (QTc) interval ? 470 msec on screening electrocardiogram (ECG)
STRATUM A: Participants with QTc interval of > 450 msec on screening electrocardiogram (ECG)
Electrocardiogram (ECG) without evidence of clinically significant ventricular arrhythmias or ischemia as determined by the investigator and a rate-corrected QT interval (QTc, Bazett's formula) of < 480 msec
Baseline electrocardiogram (EKG) with corrected QT (QTc) > 470 msec (including subjects on medication); subjects with ventricular pacemaker for whom QT interval is not measurable will be eligible on a case-by-case basis at medical doctor (MD) discretion
Cardiac electrophysiologic stability as defined by an electrocardiogram (ECG) with a corrected QT (QTc) interval < 500 msec at screening
Patients with a corrected QT (QTc) interval of > 450 milliseconds (msec) on screening electrocardiogram (ECG) for men or > 470 msec for women
Electrocardiogram (ECG) - corrected QT (QTc) < 480 msec, within 2 weeks of registration (except where specified otherwise)
Baseline corrected QT Interval (QTc) > 470 milliseconds (msec) in women and > 450 msec in men; concomitant treatment with medications that prolong the QT interval and have a known risk of Torsades De Pointes is not contraindicated, but should be avoided if possible and will require more frequent electrocardiogram (EKG) monitoring
Corrected QT interval (QTc) > 480 msec on screening electrocardiogram; if QTc prolongation is felt to be related to electrolyte imbalance, an electrocardiogram (EKG) can be repeated after correction of electrolytes
Electrocardiogram (EKG) corrected QT interval (QTc) < 450 msec (females)
Normal electrocardiogram with corrected QT (QTc) =< 450
Resting electrocardiogram (ECG) with corrected QT interval (QTc) > 470 msec (Fridericia’s scale)
QT interval corrected for rate (QTc) ? 480 msec on the electrocardiogram (ECG) obtained at Screening
12-lead electrocardiogram (EKG) showing no active ischemia and corrected QT (QTc) interval less than 480 msec
Subject has corrected QT (QTc) interval < 500 msec on baseline electrocardiogram
QT interval corrected for rate (QTc) ? 480 msec on the electrocardiogram (ECG) obtained at Screening (average of 3 readings)
Rate-corrected QT interval of electrocardiograph (QTc) > 470 msec on a 12-lead electrocardiogram (ECG) during screening
Baseline electrocardiogram (EKG) with corrected QT interval (QTc) > 470 msec (including subjects on medication); subjects with ventricular pacemaker for whom QT interval is not measurable will be eligible on a case-by-case basis
Screening electrocardiogram (ECG) with a corrected QT interval (QTc) > 460 msec confirmed by central laboratory prior to enrollment to the study
206 Baseline electrocardiogram (ECG) QTc > 470 msec.
Obtained =< 7 days prior to registration: Corrected QT (QTc) interval =< 500 msec on the baseline electrocardiogram
Corrected QT (QTc) interval > 480 msec on baseline electrocardiogram (EKG)
Electrocardiogram (ECG) corrected QT (QTc) =< 450 msec
Corrected QT (QTc) interval on electrocardiogram must be =< 480 msec (Fridericia correction)
Patients must have corrected QT (QTc) interval < 500 msec on baseline electrocardiogram (EKG)
Patient must have a corrected QT interval (QTc) interval < 461 msec on the 12 lead electrocardiogram (ECG) within 42 days prior to registration, patients with asymptomatic or incidental bundle branch blocks may have QTc measured by a cardiologist or standard formulas such as Bazett’s or Fridericia’s to adjust for pre-existing blocks
Patients with prolonged corrected QT (QTc) interval (> 500 msec) determined by electrocardiogram (EKG) within 28 days prior to registration
Patient must have a corrected QT (QTc) interval on electrocardiogram (ECG) =< 0.48 seconds by Bazett’s calculation at screening
For purposes of this data analysis, Bazett's formula will be used as the primary method of calculating the corrected QT interval. The QTc should be based on either a single Electrocardiogram (ECG) or an average of 3 sequential ECGs obtained within 24 hours of each other.
Patients must have a baseline electrocardiogram (ECG) showing corrected QT (QTc) interval =< 460 msec within 28 days prior to registration
On electrocardiogram, corrected QT (QTc) interval > 500 msec
Electrocardiogram (ECG) without evidence of clinically significant ventricular arrhythmias or ischemia as determined by the investigator and a rate-corrected QT interval (QTc, Bazett's formula) of < 480 msec
Corrected QT (QTc) =< 500 msec on baseline electrocardiogram (ECG)
Baseline corrected QT (QTc) > 480 msec or other clinically significant baseline electrocardiogram (ECG) abnormality
At eltrombopag dose levels 200 mg and above cohorts, subjects with a corrected QT (QTc) > 480 msec at screening, if other drugs known to cause prolonged QT are stopped an electrocardiogram (EKG) documenting QTc below 480 msec is required
Has electrocardiogram (ECG) abnormalities that make QT interval corrected (QTc) evaluation difficult.
Grade >= 2 QT interval corrected (QTc) prolongation on screening electrocardiogram (ECG) within 28 days of enrollment, or history of ventricular arrhythmia
QT/QTc interval >480 msec, before C1D1 treatment administration, as determined by screening electrocardiogram (ECG)
Cardiac function: 12-lead electrocardiogram (ECG) with normal tracing, or non-clinically significant changes that do not require medical intervention; corrected QT (QTc) interval is to be < 470 msec
Corrected QT interval (QTc) prolongation (defined as a QTc interval > 480 msec) or other significant electrocardiogram (ECG) abnormalities
Patients with corrected QT (QTc) prolongation (defined as a QTc interval equal to or greater than 500 msec) or other significant electrocardiogram (ECG) abnormalities are excluded
Screening electrocardiogram (EKG) with a corrected QT (QTc) > 450 msec
Have corrected QT (QTc) interval of >470 milliseconds on screening electrocardiogram (ECG).
Corrected QT interval (QTc) > 500 milliseconds in a 12-lead electrocardiogram (ECG) during screening.
Baseline corrected QT interval (QTc) > 470 msec (average of triplicate electrocardiogram [ECG] recordings); a consistent method of QTc calculation must be used for each patient's QTc measurements; QTcF (Fridericia's formula) is preferred
Patients must not have prolonged corrected QT (QTc) interval (> 500 msec) determined by electrocardiogram (EKG) within 28 days prior to registration
QT/QTc interval >450 msec, as determined by screening electrocardiogram (ECG)
Corrected QT interval (QTc) < 480 msec (with Bazett’s correction) in screening electrocardiogram
Electrocardiogram (EKG) with mean corrected QT (QTc) interval < 450 msec
Corrected QT (QTc) interval > 500 msec on baseline electrocardiogram (EKG)
Have QTc interval of >500 msec on screening electrocardiogram
Patients must have electrocardiogram with corrected QT (QTc) with correction within 28 days prior to registration
QTc interval < 480 milliseconds (msec) on the baseline electrocardiogram.
Corrected QT interval (QTc) > 450 msec (male) or > 470 msec (female) on 12-lead electrocardiogram
Have corrected QT interval of >500 millisecond (msec) on screening electrocardiogram (ECG).
Have corrected QT interval of >470 milliseconds on screening electrocardiogram (ECG).