Disease that can be accessed by a bronchoscopic, surgical or percutaneous biopsy, eligible for biopsy from safety perspective, and agrees to biopsy prior to study; the pre-study biopsy can be waived if there is an archival biopsy specimen that was obtained after the most recent therapy or if the risks of biopsy are judged to be excessive by the study principal investigator (PI)
Disease that can be safely accessed via bronchoscopic, thoracoscopic or percutaneous biopsy, and willingness to undergo biopsy before and after treatment