Patients must have evidence of disease progression per RECIST 1.1 prior to enrollment or have evidence of cancer-related pain requiring symptom management with narcotic analgesics
Performance Status of 0- 2 (unless due to bone pain)
Three or more pain crises per year in the 2-year period preceding enrollment (required intravenous pain management in the outpatient or inpatient hospital setting). Clinical documentation of pain management in the inpatient or outpatient setting is required.
Administration of regular RBC transfusion therapy, defined as receiving 8 or more transfusion events per year (in the 12 months before enrollment) to prevent vaso-occlusive clinical complications (i.e. pain, stroke, and acute chest syndrome)
Has developed chest pain in the past month
Severe peripheral vascular disease (i.e., severe claudication [pain occurring after less than 200 meters of walking], rest pain, ischemic ulceration or gangrene) in subjects whose Injectable Lesions are located in an extremity.
Planned palliative procedures for alleviation of bone pain
Participants with uncontrolled or chronic pain, a score greater than 4 on the standard pain scale, will be excluded unless otherwise approved by the principal investigator or PI’s designee
Uncontrolled cancer pain. Participants requiring pain medication must be on a stable regimen at study entry. Symptomatic lesions amenable to palliative radiotherapy should be treated prior to enrollment.
Patients with any anginal chest pain; defined by a known diagnosis of angina; or defined by chest pressure, squeezing, radiating pain to arms, shoulders, or neck from the chest; with or without exertion
use of opiate analgesics for prostate cancer pain within 4 week of treatment start
Symptomatic prostate cancer as determined by cancer-related pain requiring narcotic pain medication or any other clear and unequivocal symptoms related to prostate cancer
Pain symptoms should be stable (of tolerable Grade 2 or less).
Pain due to metastatic prostate cancer requiring treatment intervention
TSS of ?10 on the MPN-SAF TSS 2.0 or patients with a single symptom score of ?5 or two symptoms of ?3, including only the symptoms of left upper quadrant pain, bone pain, itching, or night sweats
Use of opioid medications for cancer-related pain, including codeine and dextropropoxyphene, currently or any time within 4 weeks of Day 1, Cycle 1
Use of opioid analgesics for cancer-related pain
Prostate cancer pain requiring regularly scheduled narcotics
Patients taking steroids for disease control or pain management
Moderate or severe symptomatic metastatic disease; subjects who meet either of the following criteria must be excluded:\r\n* A requirement for treatment with opioid analgesics for any reason within 28 days prior to registration\r\n* Average weekly pain score of 4 or more as reported on the 10-point Visual Analog Scale (VAS) on the Registration Pain Log
Patients must have severe SCD defined as 1 or more of the following:\r\n* Clinically significant neurologic event (stroke) or any neurological deficit lasting > 24 hours\r\n* History of >= 2 episodes of acute chest syndrome (ACS) in the 2-year period preceding enrollment despite the institution of supportive care measures (i.e. asthma therapy and/or hydroxyurea)\r\n* History of >= 3 severe pain crises per year in the 2-year period preceding enrollment despite the institution of supportive care measures (i.e. a pain management plan and/or treatment with hydroxyurea)\r\n* Administration of regular red blood cell (RBC) transfusion therapy, defined as receiving >= 8 transfusions per year for >= 1 year to prevent vaso-occlusive clinical complications (i.e. pain, stroke, and acute chest syndrome)\r\n* An echocardiographic finding of tricuspid valve regurgitant jet (TRJ) velocity >= 2.7 m/sec in adult patients
Report worst pain score ?4/10 at the target treatment site within the past 24 hours
Significant liver metastasis or disease-related bone pain requiring scheduled narcotics
Histologically confirmed advanced cancer or metastasis, which has not responded to standard therapy, producing intractable chronic pain in the target area.
Must have average worst pain score within specific range on the NPRS from assessment.
Subjects with additional loci of pain above the mid-thoracic level or other pain disorder due to non-cancer etiology.
Asymptomatic or minimally symptomatic patients (do not require narcotics for prostate cancer-related pain).
Participants with uncontrolled tumor-related pain\r\n* Symptomatic lesions amenable to palliative radiotherapy (e.g., bone metastases or metastases causing nerve impingement) should be treated prior to enrollment\r\n* Asymptomatic metastatic lesions whose further growth would likely cause functional deficits or intractable pain (e.g., epidural metastases that are not currently associated with spinal cord compression) should be considered for loco-regional therapy if appropriate prior to enrollment
Residual side effects from chemotherapy or radiation, which have not gotten better except for nerve pain or tingling or hair loss.
Uncontrolled tumor-related pain\r\n* Subjects requiring pain medication must be on a stable regimen at study entry\r\n* Symptomatic lesions amenable to palliative radiotherapy (e.g., bone metastases or metastases causing nerve impingement) should be treated prior to enrollment\r\n* Asymptomatic metastatic lesions whose further growth would likely cause functional deficits or intractable pain (e.g., epidural metastasis that is not currently associated with spinal cord compression) should be considered for loco-regional therapy if appropriate prior to enrollment
Patients must have minimal or no disease related-symptoms (minimal symptoms will include those that do not affect activities of daily living or pain that does not require regularly scheduled narcotics)
A score of 0-1 on Brief Pain Inventory (BPI)-Short Form (SF) question 3 (worst pain in last 24 hours) will be considered asymptomatic, and a score of 2-3 will be considered mildly symptomatic
Numerical rating pain scale within 1 week prior to registration; documentation of the patient’s initial pain score is required; patients taking medication for pain at the time of registration are eligible
Rapidly progressive symptomatic metastatic disease, as defined by the need for increased opioid analgesics within one month of registration for the treatment of pain attributed to a prostate cancer metastatic lesion; patients receiving opioids must receive approval from the principal investigator (PI) for eligibility
Existing chronic bone pain prior to pegfilgrastim usage
Pain due to metastatic prostate cancer requiring opioid analgesics
Pain that developed or worsened since breast cancer diagnosis and is not due to identifiable traumatic event or fracture
Patient-reported worst pain score between 5 and 10 (inclusive) on a 0-10 scale (assessed verbally)
Thumbnail abnormalities on either hand (such as due to chemotherapy or trauma, or artificial nails) that are likely to alter pain perception during testing
Patients must have had a visual analog scoring of pain >= 4 at the planned treated site within 14 days of registration; pain must be ongoing or require narcotic pain medicine to control
Narcotic pain prescription and usage information must be available and documented
Uncontrolled pain that results in patient's lack of compliance with the imaging procedures
Ileus, abdominal pain, extensive denudation of intestinal mucosa or stage 4 GI GvHD.
Patients with persistent distinguishable pain associated with up to 3 tumors of which a maximum of 2 tumors will be treated: o If patient has pain from additional sites that are not planned for treatment, the pain from the additional sites must be evaluated as being less intense by at least 2 points on the NRS compared to the site(s) to be treated.
Patients with persistent undistinguishable pain (pain source unidentifiable)
Patients with pain attributable to their prostate cancer
Patients with pain and oral dysfunction associated with oral mucositis despite conventional therapy
Prostate cancer pain requiring regularly scheduled narcotics
Neuropathic pain =< grade 1
Patients with minimal or no disease related-symptoms (minimal symptoms will include those that do not affect activities of daily living or pain that does not require regularly scheduled narcotics)
Moderate or severe symptomatic metastatic disease, defined as a requirement for treatment with opioid analgesics for cancer-related pain within 21 days prior to registration
Asymptomatic or minimally symptomatic disease as demonstrated by Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 and no need for opiate pain medications to control pain/symptoms
Solid tumors with tumor-induced pain
Current analgesic therapies have failed, the subject is not a candidate for, OR the subject is not experiencing adequate pain relief from current pain therapies (e.g. radiation, analgesics)
The 'worst pain' in the last 24 hours must be reported to be 4 or above on a scale of 0 (no pain) to 10 (pain as bad as subject can imagine)
All subjects must have radiologic or pathologic evidence of ? 2 skeletal lesions with or without pain at baseline on bone scan or axial imaging or 1 skeletal lesion and bone pain within 28 days prior to the registration.
Patients with one-sided, somatic pain due to tumor involvement below the shoulder level (C5 dermatome)
Patients with refractory cancer pain who are seen by the supportive care or pain medicine teams, and who either (1) are on appropriate opioid therapy at the time of consultation, or (2) who undergo an initial consultation and at least 2 clinical follow-up evaluations by these services
history suggestive of hepatitis B infection, e.g., dark urine, jaundice, right upper quadrant pain.
Tumor-related pain increased above baseline for 2 weeks and not controlled by a stable dose of opiates
Steroids for the treatment of hypersensitivity or transfusion reactions, nausea/vomiting or pain
Use of opiate analgesics for prostate cancer pain within 4 weeks before enrollment;
a worst pain of at least 4 at any time during the week preceding the Screening Visit (based on scale of 0 to 10, with 10 representing \pain as bad as you can imagine\).
During the 2 weeks prior to randomization, at least 4 of 7 consecutive days of BPI Worst Pain NRS items and Worst Stiffness NRS items completed correctly.
Willingness and ability to complete the Worst Pain NRS item, Worst Stiffness NRS item, PROMIS Physical Function Scale, and other self-assessment instruments throughout the study.
The patient has pain that is persistent and distinguishably associated with the target sites to be treated; the patient’s average Brief Pain Inventory (BPI) pain score (0-10 scale) for last 72 hours at specified location is > 3
Use of controlled schedule III controlled substances for cancer-related pain control
Patients have to meet one of the following criteria to be eligible:\r\n* Disease determined unresectable or entailing unacceptably morbid surgery based on 1 or more of the following characteristics:\r\n** Multifocal disease\r\n** Disease in which there is involvement or inadequate plane from: neurovascular bundle, bone, skin, or viscera\r\n** Large size in relationship to location OR multi-compartment involvement\r\n* Progression by radiographic imaging (10% increase in size by RECIST v1.1 within 6 months of registration)\r\n* Patients with symptomatic disease which meets the following criteria Brief Pain Inventory (BPI) score greater than or equal to 3 AND one of the following:\r\n** Inability to control pain with NSAIDs and considering addition of narcotics OR\r\n** > 30% increase in current use of narcotics OR\r\n** Addition of a new opioid narcotic
Use of opiate analgesics for cancer-related pain, including codeine and dextropropoxyphene, currently or anytime during the 4- week period prior to randomization.
Asymptomatic or mildly symptomatic from prostate cancer\r\n* A score of 0-1 on Brief Pain Inventory-Short Form (BPI-SF) Question #3 (worst pain in last 24 hours) will be considered asymptomatic, and a score of 2-3 will be considered mildly symptomatic
Prostate cancer pain requiring regularly scheduled narcotics.
At least 4 weeks and recovery to grade 0-1 from reversible effects or prior surgery (i.e., incisional pain, wound drainage)
Reporting being bothered by vulvovaginal symptoms of estrogen deprivation (i.e., vulvovaginal dryness or discomfort [pain with intercourse or examination])
Symptomatic metastatic disease, as defined by the need for opioid analgesics for the treatment of pain attributed to a prostate cancer metastatic lesion; patients receiving opioids must receive approval from the principal investigator (PI) for eligibility
Patients with a pelvic mass of any size that is causing pain, or other subjective symptoms that are intolerable to the patient
Patients should be asymptomatic for jaundice and ascites prior to day 1; pain symptoms should be stable
Indwelling post-operative epidural catheter for pain control
Brief Pain Inventory (BPI) worst pain score of ? 4 (irrespective of medication),
Significant clinical morbidities (aside from the index vertebra(e) and recurrent cancer) that may interfere with data collection that affects pain and functional results,
Pain symptoms should be stable and should not require modifications in analgesic management prior to Cycle 1 Day 1.
Subject has chronic low back and leg pain secondary to Failed Back Surgery Syndrome (FBSS)
Subject has an average score of 6 or higher for average daily overall pain on the Numerical Rating Scale (NRS) based on the 7 day pain diary
Subject's pain-related medication regimen is stable 4 weeks prior to the baseline evaluation
Subject agrees not to add or increase pain-related medication throughout the 12 week randomized evaluation phase of the study (starting at activation)
Clear symptomatic deterioration supported by at least two of the following clinical criteria: ? 10% worsening in KPS or ? 1 worsening in ECOG; increasing weakness or fatigue; progressive weight loss; new/worsening pain requiring increased pain medication; new/worsening jaundice, nausea, or vomiting; new/worsening ascites or pleural effusions; other physical or laboratory findings consistent with disease progression.
Current analgesic therapies have failed (worst pain of 4 or above as measured by Brief Pain Inventory [BPI], despite analgesic therapy) OR the subject is experiencing intolerable side effects that preclude analgesic use (resulting in pain of 4 or above, as measured by BPI)
Radiation while on study is not allowed EXCEPT to a localized region for pain control
Pain scale score >= 5
Pain with a focus at the involved vertebral body that is not adequately controlled by medical management
Pain not localized to the region of metastatic disease; this may include:\r\n* Diffuse non-focal back pain\r\n* Radiculopathy
VAS Pain Score > 60mm on 100mm scale. -Impending Fracture-Specific Inclusion Criteria
Impending or actual fracture at any other location that, in the Investigator's opinion, would preclude ability to assess pain and/or function in the target humerus.
Between 2 and 10 sickle cell-related pain crises in the past 12 months
Previous extensive radiotherapy except limited field RT for locally advanced nasal NK PTCL or for pain palliation
Subject is experiencing acute pain typical of vaso-occlusive crisis requiring treatment with parenteral analgesia
Zubrod Performance Status (PS) of </= 2; or 3 if of recent onset (i.e. < 2 weeks) and if the compromised performance status is related to uncontrolled pain which is expected to come under control by means of improved pain management.
Persistent clinically significant toxicities from prior chemo ? Grd 1 or Grd 2 neuropathy without pain
Persistent clinically significant toxicities from prior chemo ? Grd 1, or Grd 2 neuropathy without pain.
Significant neuropathy (Grd 3-4 or Grd 2 with pain) at the time of 1st dose
Significant neuropathy (Grd 3-4 or Grd 2 with pain) at the time of 1st dose
Use of opiate analgesics for cancer-related pain, including codeine and dextropropoxyphene, currently or anytime within 4 weeks of Cycle 1 Day 1
Is receiving opioids on a regular schedule, not just as needed to control pain.
Patients must not be currently taking (or have taken in the past 6 months) medication for active, chronic conditions, including rheumatoid arthritis, carpal tunnel syndrome, tenosynovitis, systemic lupus erythematosus, gout, fibromyalgia, or severe osteoarthritis involving the hands, wrists, hips, knees, feet or ankles; this includes analgesic medications or medications being taken with the purpose of treating pain or that may have an effect on pain (e.g. anti-depressants for help with pain or neuropathy, corticosteroid shots for arthritis); (Note: patients taking daily low dose aspirin are allowed to participate in this trial)
Patients must have worst pain rated as no worse than 3 out of 10 on the following question (i.e., a pain score of 0, 1, 2, or 3): “In the past week, how much pain have you had on a scale of 0 to 10, where 0 equals no pain and 10 means the worst pain you can imagine; \ NOTE: this question regarding patient’s pain should be completed within one week prior to registration; this question may be asked orally prior to consent up to 7 days prior to registration; the response will be recorded on the registration checklist
Patients who report a baseline pain score > 3, unrelated to a breast procedure
Having musculoskeletal pain, defined as regional (joints, extremities, back, neck) or more generalized (fibromyalgia or chronic widespread pain)
Having a pain rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week (patients with a neuropathic component to their pain that involves the extremities or back will be eligible)
Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days
Have non-musculoskeletal pain syndromes (headache, facial pain, chest pain, visceral abdominal pain) if these are the sole source of pain, but can be present as co-morbid conditions as long as a patient has a primary musculoskeletal pain condition defined as above
Phantom limb pain
Have a pending pain-related Veterans Administration (VA) or social security or worker's compensation (comp) disability claim by self-report
Patients with pain or dysesthesia
Patient has uncontrolled cancer pain despite analgesic therapy
PATIENT INCLUSION: Worst pain in the past 2 weeks greater than or equal to 4 on the 0-10 pain scale
PATIENT EXCLUSION: Current radiation therapy that in the opinion of the investigator is significantly affecting pain
Pain at baseline as measured by a BPI worst pain score average of >= 3; the BPI worst pain score average will be based on the worst pain scores completed by the patient in the 7 consecutive pretreatment days; a minimum of 4 days of pain scores must be completed by the patient in the 7 day window in order to calculate the average worst pain score; the investigator will optimize the subject’s pain regimen prior to study entry
Patient with NRS (0-10 scale) pain score ? 4 irrespective of medication
Worst pain NRS still ? 4 And
Patients with persistent distinguishable pain associated with 1 site to be treated (if patient has pain from additional sites, the pain from the additional sites must be evaluated as being less intense by at least 2 points on the NRS compared to the site to be treated).
Patients with persistent undistinguishable pain (pain source unidentifiable of the targeted lesion)
Moderate to severe CIPN, defined by symptoms such as numbness, tingling, or pain ratings of 4 or greater on a 0–10 NRS scale
Moderate to severe CIPN, defined by symptoms such as numbness, tingling, or pain ratings of 4 or greater on a 0-10 numeric rating scale (NRS)
Evidence of >= grade 2 gastrointestinal toxicity (including, but not limited to: nausea, vomiting, anorexia, gastrointestinal pain)
Patients with previous pain disorders or drug abuse requiring chronic narcotic use
Pain in the abdomen with an average daily pain rating of >= 4 out of 10, using the following question from the Brief Pain Inventory (BPI): “Please rate your pain by circling the one number that best describes your (abdominal) pain/discomfort on average over the past week (Scale 0-10; 0= No pain, 10= Pain as bad as you can imagine)”
Under formal pain management contract with a pain management specialist.
At least moderate pain (pain score >= 4) at recruitment
Numeric pain rating scale of >= 7 out of 10
Patients with uncontrolled pain related to cancer or cancer treatment; uncontrolled pain will be defined as\r\n* Pain which persists for more than 7 days and is rated >= 6 on NPRS\r\n* Use of breakthrough medication more than 4 times in 24 hours or being treated with oral morphine equivalent of 100 mg/d or more
Patients who are willing and able to maintain a daily pain diary
Use of narcotic pain medication, benzodiazepines, or illicit drugs for seven days prior to and during study participation
Pre-existing pain in the axilla affecting ability to use extremity for activities of daily living or requiring medication for treatment
Patient must be on a stable dose of adjuvant pain therapies for one week prior to screening or after 4-5 half-lives of adjuvant pain therapies (i.e., glucocorticoids, nonsteroidal antiinflammatory drug [NSAIDs], anticonvulsants, pharmaceutical cannabinoids, tricyclic antidepressants)
Patient has uncontrolled or rapidly escalating background pain
Uncontrolled pain; if patient is on opioids for the treatment of cancer pain, he/she must have had no major dose change (> 25%) for at least 48 hours prior to study entry; the dose of morphine equivalent daily should not exceed 120 mg/day unless approved by the principal investigator (PI); change in opioid dose after study entry is allowed
Significant pain during core biopsy as reported by the patient
Must either be getting her first mammogram or based on prior experience be expecting level 3, 4 or 5 pain
May not have taken ibuprofen or other pain medication within the last 12 hours (aspirin [ASA] 81 mg dose is allowed)
Having a pain intensity rating of >= 5; a pain score of 5 is considered to be moderate pain
Have persistent pain (unrelated to aromatase inhibitors or chemotherapy-induced peripheral neuropathy) for at least 3 months following treatment for breast cancer
Have pain severity (arithmetic mean of four pain severity items) >= 2 on Brief Pain Inventory (BPI)
Have worst pain >= to 4 (0-10 numeric rating scale [NRS]) in the preceding week
Patients with chronic pain syndromes
Pain score of at >= 5 on a scale of 0 – 10 within a week of enrollment OR pain score < 5 with >= 60 mg of morphine (or equivalent) per day
Significant preoperative chronic pain (requiring daily narcotics) or neuropathic pain (requiring daily use of pregabalin or gabapentin) within the previous 3 months
Experiencing ongoing pain and/or stiffness in one or more joints, which started or worsened after initiation of AI therapy
Having a baseline worst pain score over the past week on the Brief Pain Inventory–Short Form (BPI-SF) of >= 3 on a 0 to 10 scale
Has developed chest pain in the past month
Moderate-to-severe bone pain (i.e., National Cancer Institute’s Common Terminology Criteria for Adverse Events grade 2-3 bone pain)
Pain score >= 4 on a 0-10 numeric pain scale and/or grade 3 neuropathic symptoms according to the National Cancer Institute’s 4 point grading scale
Patients must report neuropathic pain for a minimum of 3 months
No plans to change pain medication regimen during the course of the study
Patients with pain at rest or with movement measured by numeric rating scale (NRS) > 2
Patient must self-report having chronic pain for at least the past 3 months that has interfered with their daily functioning, as assessed by the Pain Interference Index (must get a mean score of 2.0 or higher, or score a 3 on three or more individual items)
No anticipated major changes in their pain treatment regimen (i.e., new class of pain medication starting or change in the class of pain medication) or enrollment on a new treatment study presumed to impact pain in the near future
Subjects who are participating in any other treatment studies, either medical or behavioral, specifically for pain management
Subjects who began a medical intervention for treatment of their disease that has a possible impact on pain (including mitogen-activated protein kinase kinase [MEK] trials) will not be eligible until after one year on the medical treatment; at that time, eligibility will be discussed with the PI of the medical study to assess the stability of the patient’s pain and whether further pain-related changes due to the medical treatment are likely
Current pain level >= 3 and at least one prior score >= 3 on a 0-10 scale as reported in inquiries of electronic health records (EPIC)
Report average pain >= 3 during the first nine months after surgery on the Breast Cancer Pain Questionnaire
Patients must have the ability to understand visual and verbal pain scales
Distal symmetric pain distribution (both feet, with or without pain in hands)
Score of 4 or more on Douleur Neuropathique 4 (DN4) neuropathic pain questionnaire
Pain duration > 2 months
Patient report of average daily pain intensity > 3 on 0-10 Numerical Rating Scale (NRS) in the past week
Inability to complete pain self-report
Patients who have frank mechanical pain
Taking daily antihistamines for allergies, asthma, or other indications, not including bone pain
Having 2 clinical pain ratings of >= 3 gathered as part of their routine clinic visits at least 3 weeks apart but not more than 12 months apart
Current or past (< 6 months) engagement in pain coping skills training protocol for cancer
Evaluation by a pain management physician and confirmation that cancer is the primary etiology of patient’s pain
Moderate to severe pain, as specified by a baseline pain rating score of 5 or above on a scale from 0 (no pain) to 10 (worst pain imaginable) despite current opioid therapy
Pain management plan (as developed by Interventional Pain Service, patient and primary service) that includes placement of an intrathecal drug delivery system for pain management
Acute coronary syndrome as defined by active chest pain, dynamic electrocardiogram (ECG) changes, troponin greater than 2.5
Report a clinical pain score of >= 3/10
Subjects with mucositis pain refractory to topical management, defined as any self-reported pain score of >= 2 in the 24 hours prior to enrollment despite use of topical agents as prescribed
Pain or symptoms of neuropathy or pain of >= 1 month (30 days) duration for which the patient wants intervention
Participants have to relate that tingling or pain was at least a four out of ten problem during the prior week, on a 0-10 scale where zero was no problem and ten was the worst possible problem and expected to have tingling or pain of at least 4/10 at the time of the first treatment
Subjects report persistent pain in the distribution of the intercostobrachial nerve (ICBN): The residual breast, surgical bed, ipsilateral medial arm, and/or axilla following tissue healing (> 3 months post-procedure)
Positive response to local anesthetic peripheral nerve block performed under imaging guidance, defined as a >= 50% change in Visual Analog Scale (VAS) pain intensity
Diagnosis of cancer related pain currently treated with first line strong oral opioid analgesics such as morphine, oxycodone, oxymorphone, hydromorphone or hydrocodone
Presence of pain primarily due to chemotherapy induced peripheral neuropathy
Non-malignant pain
Neuropathic pain score >= 4 on a 0-10 numeric pain scale (numeric rating scale [NRS]) and/or grade 3 or higher neuropathic symptoms according to the National Cancer Institute’s 4 point grading scale.
No plans to change pain medication regimen during the course of the study.
Patients with pain requiring opioid pain medication; NOTE: over the counter analgesics such as Tylenol or ibuprofen are allowed
Patients scoring greater than 4 on a 0 to 10 scale with regard to sleep troubles or pain
Patients who are on medications for chronic pain
Patients with chronic pain syndrome or requiring/using chronic pain medications
History of chronic pain and/or daily opioid use
Numerical Rating Pain Scale within 1 week prior to registration; the patient must have a score on the scale of >= 5 for at least one of the planned sites for spine radiosurgery; documentation of the patient's initial pain score is required; patients taking medication for pain at the time of registration are eligible
Widespread chronic pain conditions such as fibromyalgia
Any patients prescribed medications for chronic pain and/or neuropathy will be excluded, including patients under treatment of a pain specialist or substance-abuse programs
Patients already enrolled on other studies of systemic pain control agents
Change in pain medications/sleeping medications/anxiety medications/antiemetics during the trial
Cancer patients with pain that is not curable and who have not responded to opioids at reasonable doses
Able to verbally report pain
Able to indicate pain on a VAS
Arthralgia is moderate to severe joint symptoms-pain, stiffness or achiness-defined as a score of >= 3 on the Patient Reported Outcomes Measurement Information System (PROMIS) Pain Intensity scale (inquiring about pain, stiffness or achiness); the “at its worst” score will be used to determine study eligibility
Less than moderate to severe joint symptoms-pain, stiffness or achiness-defined as a score of =< 3 on the PROMIS Pain Intensity Short Form (SF) 3a (inquiring pain, stiffness or achiness); the “at its worst” score will be used to determine study ineligibility
Having 1 clinical pain rating of >= 3 gathered as part of routine clinic visits or reports pain of > 3 at least three days in the last two week upon accrual
>= 5/10 arthralgia (in hands, wrist, knees, or hips) while being treated with anastrozole or letrozole which is felt by the patient to be caused by their aromatase inhibitor, as measured by verbally addressing the following question: please rate your pain by picking a number, from 0 to 10 (0 being none and 10 being as bad as you can imagine) that best describes your pain from your aromatase inhibitor breast cancer medication on AVERAGE, over the past week\r\n* Note: Patients may, or may not, be taking non-opioid analgesics
Patients must have completed the S1202 Brief Pain Inventory-Short Form (BPI-SF) within 7 days prior to registration; patients must have an “average pain” of at least 4 on the BPI-SF
Able and willing to go at least 24-36 hours without narcotic pain medicine, muscle relaxants, sedatives, sleeping pills and alcohol prior to their cognitive testing; they should not have required chronic sedatives, sleeping aids, or narcotic pain medications on a daily basis prior to their diagnosis
Individuals who are not likely to be able to go for 24 yours without sleeping pills, sedatives, narcotic pain medications, or chlorpromazine (ativan)
Have an average pain intensity score in their feet and/or hands of >= 3 on a 0 to 10 numeric rating scale (NRS) and/or a rating of >= 3 on a 0 to 10 NRSs on any one of the following sensations from the Pain Qualities Assessment Scale (i.e., numb, tender, shooting, sensitive, electrical, tingling radiating, throbbing, unpleasant)
Have pain and or changes in sensation in their feet and/or hands of at least one month duration
Does NOT have changes in sensation and/or pain in their hands or feet
Patients have to relate that tingling or pain was at least a four out of ten problem =< 7 days prior to registration, on a 0-10 scale where zero was no problem and ten was the worst possible problem\r\n* Note: the patient is expected to have tingling or pain of at least 4/10 at the time of the first treatment
An average daily pain rating of >= 4 out of 10
Prior celiac plexus block, or other neurolytic pain control treatment
Persistent post-surgical pain at least 3 months after completion of surgery, chemotherapy, and/or radiation
Opioid tolerant, taking daily doses of strong opioid pain medication in the past 1 week
Background cancer pain that is =< 3/10 in the last 24 hours
Breakthrough cancer pain that is >= 4/10 in the last 24 hours
Stable pain control defined as rescue doses =< 6 in last 24 hours
Patients who report persistent or intermittent pain, including aching, tenderness, soreness
Patients who do not report any pain, including aching, tenderness, and soreness
Ability and willingness to communicate the intensity of pain using NRS at the frequency dictated by the protocol
Numeric pain rating scale of >= 7 out of 10
At least 4 (out of 10) patient-reported oral pain related to oral mucositis secondary to RT for which the patient seeks relief, as measured on the Oral Pain Assessment; Note: The pain score must be at least 4 at the time that the patient starts the first dose of study medication; the patient may be enrolled to the study if s/he, at times, has a pain score of at least 4, so long as initiation of study treatment begins when the pain score is at least 4
Previously experienced paclitaxel induced pain during a current or past paclitaxel treatment that the treating healthcare provider thinks is consistent with the paclitaxel-induced acute pain syndrome; note: formal documentation of prior pain is not required
Patient reports moderate to severe bother for at least one symptom, defined by a Rotterdam Symptom item score >= 2 on a 1-4 scale, for depressive symptoms, anxiety, pain, fatigue, sleep problems, or breathlessness
Planned use of an epidural for surgery for post-operative pain relief
Pain that is post-operative (< 3 months since surgery) or neuropathic pain; (Note: grade 1 chemotherapy-induced peripheral neuropathy [CIPN] is not anticipated to meet threshold criteria on the Neuropathic Pain Screening questionnaire); patients with more than one type of pain who are able to isolate and identify a non-neuropathic pain experience (e.g., persons with diabetic neuropathic foot pain as well as nociceptive cancer-related abdominal pain) may be included with the principal investigator (PI)’s approval
Patients with no pain and with stable pain (defined as pain under control and on stable doses of opioids for 1 week) are eligible
Controlled pain and depression symptoms, if present (defined as no change in the morphine equivalent dose of 30% or change in the dose of antidepressant medication in the past 2 weeks)
Patients must have completed the S1200 Brief Pain Inventory-Short Form (BPI-SF) within 14 days prior to registration; patients must have a worst pain score of at least 3 on the Brief Pain Inventory (item #2) that has started or increased since starting AI therapy
Controlled pain and depression symptoms, if present (defined as no change in the morphine equivalent dose of 30% or change in the dose of antidepressant medication in the past 2 weeks)
No history of skeletal related events (SRE) within past 3 months\r\n* Excruciating bone pain requiring radiation therapy (RT)\r\n* Cord compression\r\n* Hypercalcemia (serum calcium > 10.5) \r\n* Pathologic fracture
Patients will also be excluded if they have active bleeding, acute thrombosis, ischemia, hemodynamically unstable, and uncontrolled pain
chronic narcotic pain medication users
Self-report of moderate or higher pain on average during the last week (> 3 on a 0-10 pain intensity numeric scale)
Must report at least one of the following: a. “How tired did you feel in the past week?” at least 4 on a 10 point scale (with 0 = not tired at all and 10 = extremely tired) b. “Did you have trouble sleeping in the past week?” with the answer “yes” c. “What was your average pain in the past week?” at least 4 on a 10 point scale (with 0 = no pain and 10 = extremely severe pain)
Inadequately controlled pain even with the use of morphine (visual analog scale [VAS] score > 5)
Patient with rapidly escalating pain that require hospitalization or an intravenous opioid therapy
Chronic narcotic pain medication user
Unremitting pain that resulted in a return visit to the oncologist. The 'worst pain' in the last 24 hours must be reported to be 4 or above on a scale of 0 (no pain) to 10 (pain as bad as subject can imagine) despite pharmaceutical pain management
Stable use of pain medications (no changes within 2 weeks prior to the cryoablation procedure)
History of chronic pain, long-term narcotic use or being considered for chronic pain consultation postoperatively
Any condition that causes severe pain with exertion
Pain or significant arthritis in the toes of either foot;
Able to walk at least 2 blocks without chest pain, dyspnea, shortness of breath or fainting
CONTROL (HEALTHY) GROUP: Able to walk at least 2 blocks without chest pain, dyspnea, shortness of breath or fainting
Any hematologic disorder involving platelets or clotting abnormalities or any condition requiring treatment with transfusions, anticoagulants except platelet inhibitors (NSAIDs as needed for pain are permitted)
Patients who are not awake, not alert, or who cannot express pain or discomfort related to the catheter locks
Signs and symptoms of localized catheter-related infection (tenderness and/or pain, erythema, swelling, purulent exudates within 2 cm of entry site)
Willingness to self-report level of oral pain using Visual Analog Scale (VAS) and the Normalcy Diet Scale (NDS) throughout each stomatitis event, as required in the patient diary. At baseline, patient's self-reported oral pain level, using VAS, must be 0 and the normalcy diet scale score should ? 60
New onset of chest pain or arrhythmia in the past 2 months
Chest pain, angina, or heart failure
Pain in supine position
Uncontrolled tumor-related pain: patients requiring narcotic pain medication must be on a stable regimen at registration; symptomatic lesions (e.g., bone metastases or metastases causing nerve impingement) amenable to palliative radiotherapy should be treated prior to randomization; patients should be recovered from the effects of radiation; there is no required minimum recovery period; asymptomatic metastatic lesions whose further growth would likely cause functional deficits or intractable pain (e.g., epidural metastasis that is not presently associated with spinal cord compression) should be considered for loco-regional therapy if appropriate prior to randomization
GROUP B (no pain group): Must either have subjective symptoms of painless neuropathy (loss of sensation, worsening balance, strange sensation in fingers and/or toes) or no complaints related to neuropathy
Has pain rated 50 or higher on a scale of 0-100, with 0 = no pain at all and 100 = worst pain imaginable on the day of the first DLss test
Presence of pain that developed or worsened since breast cancer diagnosis (not specifically due to an identifiable trauma [eg fracture or injury]) and has been present for at least 3 months; average pain must be at least 4 on a 0-10 scale over the past 7 days
Thumbnail abnormalities on either hand (such as due to chemotherapy or trauma, or artificial nails) that are likely to alter pain perception during testing
Significant symptom burden from presumed diagnosis including large volume ascites, pain requiring narcotic medication, or shortness of breath on exertion
Significant symptom burden from presumed diagnosis including large volume ascites, pain requiring narcotic medication, or shortness of breath on exertion
Poorly-controlled pain with a self-reported pain score of 7/10 at the time of enrollment (PCS study)
Patients who are unable to validate their understanding of the pain scale
Nausea, anorexia, abdominal pain or altered bowel habit
Neuropathy with or without pain
Significant neurotoxicity (Grade 2 with pain or higher) at the time of enrolment