Adequate renal function assessed by serum creatinine within reference lab normal limits and creatinine clearance (by Chronic Kidney Disease Epidemiology [CKD-EPI] Collaboration equation) ?60 mL/min.
Creatinine clearance < 50 mL/min calculated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation
Estimated glomerular filtration rate (eGFR) > 45 mL/min (if eGFR is not included on the clinical lab report,\r\nthe chronic kidney disease epidemiology [CKD-EPI] creatinine calculator may be used)
Either an estimated creatinine clearance value of > 50 mL/min as determined by the Chronic Kidney Disease Epidemiology (CKD EPI) or MDRD (Modification of Diet in Renal Disease) formulae or a creatinine clearance value of > 50 mL/min based on a 24 hour urine collection
Calculated creatinine clearance >= 30 mL/min by the modified Cockcroft and Gault formula OR glomerular filtration rate >= 30 mL/min/body surface area (BSA) by Modification of Diet in Renal Disease or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula
Creatinine clearance (CrCl) or estimated glomerular filtration rate (eGFR) >= 60 ml/min; CrCl will be calculated by Cockcroft-Gault method; eGFR will be calculated by either of the following well established formulas: modification of diet in renal disease (MDRD) or the chronic kidney disease (CKD)-epidemiology collaboration (EPI) (institutional standard) equations; if calculated CrCl/eGFR is < 60 mL/min, patient will have a 24 hr urine collection to measure CrCl; the measured CrCl must also be >= 60 ml/min
Creatinine clearance (CrCl) < 30 ml/min/1.73m^2. Creatinine clearance is estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula
GFR ?45 mL/min/1.73 m2 calculated by CKD-EPI
Creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal (by the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation)
Creatinine >1.5 times ULN or creatinine clearance <50 mL/min (measured or calculated by Chronic Kidney Disease Epidemiology (CKD-EPI) Collaboration equation); confirmation of creatinine clearance is only required when creatinine is >1.5 times ULN.
Estimated (by Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] or Cockgroft-Gault equations) or calculated creatinine clearance (CrCl) >= 40 ml/min
Creatinine clearance > 50 mL/min (calculated according to institutional standards or using Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD], or Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] formula)
Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of normal (ULN) OR estimated glomerular filtration rate (GFR) per Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation >= 60 mL/min for subject with creatinine levels > 1.5 X institutional ULN
Calculated (using the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) or measured creatinine clearance < 75% lower limit of normal (LLN)
Estimated glomerular filtration rate (eGFR) (chronic kidney disease [CKD]-epidemiology collaboration [EPI]) >= 50 mL/min/1.73 m^2
TREATMENT: Glomerular filtration rate (GFR) > 30 mL/min (calculated by the Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD] study, or Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] creatinine equations, or equivalent)
Creatinine clearance or glomerular filtration rate ?30 mL/min as estimated by the Cockroft-Gault (C-G) or other medically acceptable formulas, such as MDRD (Modification of Diet in Renal Disease) or CKD-EPI (the Chronic Kidney Disease Epidemiology Collaboration).
Serum creatinine < 1.5 x upper limit normal (ULN) or estimated glomerular filtration rate (GFR) > 50 mL/min based upon Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation. Patients with estimated GFR between 50 - 60 mL/min at baseline will require a 99mTc-DTPA GFR test and only patients with non-obstructive pathology will be included in the study.
Glomerular filtration rate (GFR) ?30 ml/min/1.73 m2 (assessed using the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation)
GFR <60 mL/min/1.73 m2 (assessed using the CKD-EPI equation)
Creatinine within institutional normal limits or glomerular filtration rate >= 30 mL/min/1.73 m^2 by chronic kidney disease (CKD) epidemiology collaboration (EPI) equation
Creatinine clearance >= 50 mL/min by either measured (using the Cockcroft-Gault, Modification of Diet in Renal Disease [MDRD] or Chronic Kidney Disease Epidemiology [CKD-EPI] formula) or calculated clearance (i.e. glomerular filtration rate [GFR])
Estimated glomerular filtration rate (eGFR) >= 50 ml/min/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, obtained within 14 days prior to the first study treatment (cycle 1, day 1)
Creatinine clearance or glomerular filtration rate ?30 mL/min estimated by the Cockroft-Gault (C-G) or other medically acceptable formulas such as MDRD (Modification of Diet in Renal Disease) or CKD-EPI (the Chronic Kidney Disease Epidemiology Collaboration).
Creatinine clearance < 30 mL/min, not eligible for bisphosphonate; estimated glomerular filtration rate will be calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and/or the Cockcroft-Gault equation
Estimated glomerular filtration rate (GFR) ?30 mL/min as assessed by CKD-epi, MDRD or the Cockcroft-Gault Equation
Estimated glomerular filtration rate (GFR) (calculated using Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) >= 30 mL/min/1.73 sq.m.
Estimated glomerular filtration rate >= 60 ml/min/1.73m^2 using the chronic kidney disease (CKD)-epidemiology (EPI) equation
Absence of renal failure attributed to the plasma cell disorder*: calculated creatinine clearance (according to Cockcroft-Gault method, Modification of Diet in Renal Disease [MDRD], or CKD Epidemiology Collaboration [CKD-EPI] formulae) > 30 mL/min (or alternatively based on standard creatinine level criteria of 2 mg/dl)\r\n* To be determined based on clinical and laboratory assessment by the primary oncologist
Serum creatinine > 2.0 x ULN; if creatinine 1.5 - 2.0 x ULN, creatinine clearance will be calculated according to Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and patients with creatinine clearance < 30 mL/min should be excluded
Creatinine clearance >= 60 ml/min using the Cockcroft-Gault method, Modification of Diet in Renal Disease (MDRD), or Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. If the calculated creatinine clearance (CrCl) based on Cockcroft-Gault method, MDRD, or CKD-EPI is < 60 mL/min, patient will have a 24 hour (hr) urine collection to measure CrCl.
Creatinine clearance >= 60 ml/min; creatinine clearance (CrCl) can be measured or estimated using Cockcroft-Gault method, modification of diet in renal disease (MDRD), or chronic kidney disease-epidemiology (CKD-EPI) formulae
Estimated glomerular filtration rate >= 60 ml/min/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation
Estimated glomerular filtration rate (eGFR) ?25 mL/min/1.73 m2 as estimated by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation, or measured GFR ?25 mL/min/1.73 m2
Creatinine =< 2 x upper limit of normal, unless there is known chronic kidney disease (CKD) (creatinine must be at baseline for subjects with chronic kidney disease)
Serum creatinine > 2 x upper limit of normal, unless there is known CKD (creatinine must be at baseline for subjects with CKD)
Creatinine within institutional normal limits or glomerular filtration rate >= 50 mL/min/1.73 m^2 by Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation
Creatinine clearance (CrCl) of greater than or equal to 40 mL/min. using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula; if the CrCl based on the CKD-EPI formula is < 40 mL/min, the patient will have a 24 hour (hr) urine collection to measure CrCl; the measured CrCl must also be >= 40 ml/min
Creatinine =< 1.5 x ULN OR creatinine clearance >= 40 mL/min/1.73 m^2 (calculated using the Chronic Kidney Disease-Epidemiology Collaboration [CKD-EPI] equation or Cockroft-Gault formula) for patients with creatinine levels above institutional normal
Preoperative eGFR >= 45 cc/min/1.73 m^2 as measured by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) study equation
Severe renal impairment (stage 3B) defined as eGFR < 45 cc/min/1.73 m^2 as measured by the CKD-EPI calculation
Have kidney disease, defined as either CKD II-V, determined by estimated glomerular filtration rate (GFR) of < 90 and derived from serum creatinine measurements, or albuminuria/proteinuria, determined by albumin to creatinine ratio or protein to creatinine ratio of > 30 mg/gm within 3 months of recruitment, or on dialysis or having received a kidney transplant or have biopsy proven kidney disease