Patients with seizure disorder may be enrolled if on anti-convulsants and well controlled
History of seizure disorder or active use of anticonvulsants
History of uncontrolled seizure disorder
Current or history of seizure disorder
Patients with seizure disorder requiring medication
Patients who have an uncontrolled seizure disorder, or active neurological disease
Subjects with a seizure disorder that is not well controlled or who have required a change in seizure medications within 60 days of enrollment to the trial.
History of seizure disorder.
history of seizure disorder
Patients with a seizure disorder should be well controlled
Patients with seizure disorder may be enrolled if seizure disorder is well controlled
Patients with seizure disorder requiring medication
Patients with seizure disorder requiring medication
Patients with seizure disorder requiring medication
Patients who have a history of a seizure disorder requiring anti-seizure medication.
History of seizure disorder not related to underlying cancer
Serum albumin ? 2 g/dL. Neurologic Function: • Patients with seizure disorder may be enrolled if seizure disorder is well controlled.
History of seizure disorder
Diagnosis of seizure disorder
Patients will not be eligible if they present or have a history of seizure disorder
FOR ALL PHASES (Ib AND II): Patients with seizure disorder requiring medication
Patients with seizure disorder requiring medication
Seizure disorder requiring medication
Patients with seizure disorder requiring medication
Known seizure disorder
Clinically evident CNS metastases or leptomeningeal disease not controlled by prior surgery or radiotherapy; history of seizure disorder not controlled by anti-seizure medication at the time of enrollment. Patients with primary CNS malignancies are excluded.
Patients with seizure disorder requiring medication
Seizure disorder requiring enzyme-inducing anti-epileptic drugs (EIAEDs)\r\n* Note: If the seizure disorder can be managed with agents that are not EIAEDs (e.g., levetiracetam or valproate), the patient should not be excluded
REGORAFENIB EXCLUSION CRITERIA: Patients with seizure disorder requiring medication
Patients with seizure disorder requiring medication
Prior history of seizure disorder
Seizure disorder requiring medication
Documented uncontrolled seizure disorder– a seizure disorder controlled with medication (i.e. no seizures in the previous 6 months) will not exclude a patient
Reports diagnosis of seizure disorder
Clinically evident central nervous system metastases or leptomeningeal disease not controlled by prior surgery or radiotherapy; history of seizure disorder not controlled by anti-seizure medication at the time of enrollment.
Patients with any seizure disorder
Patients with any history of seizure or seizure disorder
History of seizure disorder
History of seizure disorder
History of seizure disorder or clinically treated bipolar disorder
Have a seizure disorder where > 1 seizure has occurred within the last year.
Patients with seizure disorder requiring medication (such as steroid anti-epileptics)
Patients with seizure disorder requiring medication
Active seizure disorder uncontrolled by medication
Patient has no known history of seizure disorder
Uncontrolled seizure disorder
Patients with seizure disorder may be enrolled if well controlled
Active seizure or history of seizure disorder
Patients with seizure disorder requiring medication
Uncontrolled seizure disorder
Patients with seizure disorder requiring medication
Uncontrolled, active seizure disorder or a history of seizure
History of uncontrolled severe seizure disorder
History of uncontrolled severe seizure disorder
Patients who have an uncontrolled seizure disorder, or active neurological disease
Patients who have had a seizure within 12 months prior to enrollment and patients receiving anti-convulsant therapy for a seizure disorder.
Patients with seizure disorder requiring medication.
Uncontrolled seizure disorder, active neurological disease, or known CNS disease.
Patients with seizure disorder requiring medication
Patients with seizure disorder requiring medication.
Uncontrolled seizure disorder
Patients with seizure disorder requiring medication
Patients with seizure disorder requiring medication
Patients with seizure disorder requiring medication
Patients with any seizure disorder requiring medication
Patients with seizure disorder requiring medication
Patients with seizure disorder requiring medication
History of epilepsy or seizure disorder
A history of uncontrolled seizure disorder
Patients with seizure disorder requiring medication
Seizure disorder
Patients with seizure disorder may be enrolled if well controlled
Active central nervous system (CNS) disorder or seizure disorder
Uncontrolled seizure disorder or other serious neurological diseases
Subjects with seizure disorder currently requiring medication.
Past or current history of epilepsy or seizure disorder
Have a seizure disorder requiring medication.
History of seizure disorder
Prior history of seizure disorder
Uncontrolled seizure disorder or active neurologic disease
Known brain metastases, uncontrolled seizure disorder, or active neurologic disease
Known brain metastases, uncontrolled seizure disorder, or active neurologic disease
Uncontrolled seizure disorder or active neurologic disease
Uncontrolled seizure disorder or active neurologic disease
Uncontrolled seizure disorder requiring therapy (such as steroids or anti-epileptics with significant CYP interaction)
Seizure disorder requiring anticonvulsant therapy (such as steroids or anti-epileptics)
Uncontrolled seizure disorder.
History of seizure disorder not related to underlying cancer.
Donor must have adequate neurologic function as defined by NO evidence of a severe central or peripheral neurologic abnormality and no history of cerebrovascular accident or seizure disorder requiring anticonvulsant medication.
Uncontrolled seizure disorder, active neurological disease, or greater than Grade 2 neuropathy.
Patients with seizure disorder requiring medication
History of intractable epilepsy, or uncontrolled seizure disorder
History of seizure disorder
Uncontrolled seizure disorder
Patients with seizure disorder requiring medication
History of a seizure disorder or requirement for anti-seizure medication
Uncontrolled seizure disorder
Participant has uncontrolled seizure disorder in past 12 months
Patient must not have a seizure disorder
Subjects with a history of seizure disorder taking anti-seizure medication within 30 days prior to randomization.
Seizure disorder
Known history of epilepsy/seizure disorder
History of epileptic disorder or any seizure history unrelated to tumor
Huntington’s disease, hydrocephalus or seizure disorder
Seizure disorder