Ongoing serious, non-healing wound, ulcer, or bone fracture
History of serious or non-healing wound, ulcer, or bone fracture
Serious or non-healing wound, skin ulcer, or bone fracture
Prior osteoporotic fracture
Serious nonhealing wound, ulcer, or bone fracture
Serious non-healing wound, ulcer, or bone fracture within 6 months prior to enrollment
Serious, non-healing wound, active ulcer, or untreated bone fracture
Serious, non-healing wound, ulcer, or bone fracture.
Serious or non-healing wound, peptic ulcer, or bone fracture within 28 days prior to initiation of study treatment;
Patients with serious or non-healing wound, ulcer, or bone fracture
Patients with a serious or nonhealing wound, ulcer, or bone fracture within 28 days prior to enrollment
Serious or non-healing wound, ulcer, or bone fracture.
Presence of a non-healing wound, or non-healing ulcer, (that is not tumor related) or bone fracture
Any patient with a current non-healing wound, bone fracture, or skin ulcer is excluded
Presence of serious or nonhealing wound, ulcer, or bone fracture within 28 days prior to enrollment
Serious, non-healing wound; active ulcer; or untreated bone fracture
Presence of any non-healing wound, fracture, or ulcer within 28 days prior to study registration.
Patients with serious or non-healing wound, ulcer, or bone fracture.
Patients who have non-healing wound, unhealed or incompletely healed fracture, or a compound (open) bone fracture at the time of enrollment are not eligible
Ongoing serious, non-healing wound, ulcer, or bone fracture.
Patients with a serious non-healing wound, active ulcer, or untreated bone fracture
Presence of non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Any severe or poorly controlled systemic disease (e.g., hypertension; clinically significant cardiovascular, pulmonary, or metabolic disease, disorders of wound healing, ulcer or bone fracture)
Serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound or ulcer; bone fracture within 3 months prior to study entry
Serious or non-healing wound, ulcer or bone fracture
History or evidence of arterial thrombotic or hemorrhagic disorders within 3 months before proposed start of treatment, non-healing wound, ulcer, or bone fracture
Patients who have a non-healing wound, ulcer, or bone fracture.
Serious non-healing wound, ulcer or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture.
Non-healing wound, ulcer, non-healing traumatic bone fracture, or abscess within 30 days of enrollment\r\n* Nondisplaced, uncomplicated pathologic fracture due to tumor may be eligible provided adequately treated with radiation, surgery or other treatments with full recovery based upon investigator assessment
Has a known history of non-healing wounds or ulcers, or bone re-fractures within 3 months of fracture
Non-healing wound(s) or ulcer(s) except for ulcerative lesions caused by the underlying neoplasm;
Serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture.
Serious non-healing wound, ulcer or bone fracture
Non-healing wound, ulcer, or bone fracture
Patients who have serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture.
have any non-healing wound, fracture, or ulcer within 28 days prior to the planned start of study treatment;
(Bevacizumab-related exclusion) History of abdominal fistula or gastrointestinal perforation within 6 months prior to the first study treatment. Serious, non-healing wound, active ulcer, or untreated bone fracture (adjuvant trials: bone fractures must be healed)
Serious non-healing or dehiscing wound, active ulcer, or untreated or non-healing bone fracture
FOR ALL PHASES (Ib AND II): Non-healing wound or ulcer
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Serious or non-healing wound, ulcer, or bone fracture.
Serious, non-healing wound, active ulcer, or untreated bone fracture, including tumor-related pathological fracture
Presence of a non-healing wound, non-healing ulcer or bone fracture
History of abdominal fistula or gastrointestinal perforation =< 6 months before cycle 1, day 1; serious non-healing wound, active ulcer, or untreated bone fracture (adjuvant trials: bone fractures must be healed)
Non-healing wound, ulcer, or bone fracture
Serious, non-healing or dehiscing wound or active ulcer
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Participant has a serious, non-healing wound, ulcer, or bone fracture
Active wound, a serious or non-healing wound, an active ulcer or untreated bone fracture
Non-healing wound, bone fracture, or skin ulcer
mCRPC EXPANSION COHORT: Other clinically significant disorders such as:\r\n* Active infection requiring intravenous treatment within 7 days of starting protocol treatment\r\n* Serious non-healing wound/ulcer/bone fracture (excluding stable compression fracture) within 28 days before the first dose of study treatment
The patient has a serious or nonhealing wound, ulcer, or bone fracture within 28 days prior to enrollment
Non-healing wound, ulcer, or bone fracture
REGORAFENIB EXCLUSION CRITERIA: Presence of a non-healing wound, non-healing ulcer, or bone fracture
Non-healing wound, active peptic ulcer or bone fracture
The patient has a serious or non-healing wound, ulcer, or bone fracture within 28 days prior to enrollment
Presence of a non-healing wound, non-healing ulcer, or benign bone fracture (patients with stress insufficiency fractures e.g. from osteoporosis or pathological fracture from tumor are eligible for study)
Serious or nonhealing wound, ulcer, bone fracture, or osteonecrosis of the jaw
Subject has a serious, non-healing wound, ulcer, or bone fracture
Presence of any non-healing wound, fracture, or ulcer
Patients who have serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
Serious non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture
Serious non-healing wound, active peptic ulcer, or untreated bone fracture
Serious non-healing wound, non-healing ulcer, or bone fracture
Serious or non-healing wound, ulcer or bone fracture
The patient has a serious or non-healing wound, ulcer, or bone fracture within 28 days prior to first dose of protocol therapy
Serious, non-healing wound, active ulcer, or untreated bone fracture
A serious, non healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture; any bone fractures must be healed
Serious, non-healing wound, ulcer, or bone fracture
Non-healing wound(s) or ulcer(s) except for ulcerative lesions caused by the underlying neoplasm;
Non healing wound, ulcer or bone fracture
Non-healing serious wound, ulcer, or bone fracture unrelated to the primary tumor
Non?healing wound, ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a serious nonhealing wound, ulcer, or bone fracture
Ongoing significant, uncontrolled medical condition including: o Serious, non-healing wound, skin ulcer (of any grade), or bone fracture.
History of serious or non-healing wound, ulcer, or bone fracture
Patients with a non-healing wound, fracture, or ulcer
Non-healing wound, ulcer or bone fracture
Patients with serious non-healing wound, ulcer, or bone fracture within 28 days before registration; patients should not have had any major surgical procedures within 28 days of registration
Serious, non-healing wound, active ulcer, or untreated bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Prior major surgery within the previous 28 days of study registration and/or presence of any non-healing wound, fracture, or ulcer
Subjects with a non-healing serious wound, ulcer, or bone fracture unrelated to the primary tumor
Patients who have a serious or non-healing wound, ulcer, or bone fracture at the time of study enrollment are not eligible
Serious or non-healing wound, ulcer or bone fracture
Serious non-healing wound, ulcer, bone fracture, or abscess
Serious, non-healing wound, ulcer, or bone fracture
Patients with a serious or non-healing wound, ulcer, or bone fracture are not eligible for this study
Patients with serious non-healing wound, ulcer, or bone fracture; this includes history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 28 days; patients with granulating incisions healing by secondary intention with no evidence of fascial dehiscence or infection are eligible but require weekly wound examinations
Serious, non-healing wound, ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
The participant has a serious nonhealing: (a) wound, (b) peptic ulcer, or (c) bone fracture.
Serious, non-healing wound, infection, ulcer, bone fracture, or uncontrolled seizures
Patients with a serious or nonhealing wound, ulcer, or bone fracture within 28 days prior to enrollment
Patient must not have serious or non-healing wound, ulcer, or bone fracture at the time of randomization
Presence of any non-healing wound, fracture, or ulcer, or presence of symptomatic peripheral vascular disease
Patients are excluded if they have a non-healing wound or ulcer
Presence of non-healing wound, non-healing ulcer, or bone fracture.
Have had a serious or non-healing wound, ulcer, or bone fracture within 28 days prior to enrollment.
Serious non-healing wound, ulcer or bone fracture
Patients with serous non-healing wound, ulcer, or bone fracture.
Serious, non-healing wound, ulcer, or bone fracture requiring surgical intervention.
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Serious non-healing wound, ulcer, or bone fracture
Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture
Non-healing wound, ulcer or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture.
Has history of a non-healing wound, ulcer, or bone fracture within 90 days (3 months) prior to entry in to the trial
Serious non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture as judged by treating physician
Serious, non-healing wound, ulcer, or bone fracture
Patients with a history of a serious non-healing wound, ulcer, or bone fracture are not eligible
Serious, non-healing wound, ulcer, or bone fracture
Serious or non-healing wound, active ulcer or bone fracture
Non-healing wound, ulcer or bone fracture
Serious, non-healing wound, ulcer, or bone fracture as so judged by the treating physician
Presence of a non-healing wound or non-healing ulcer that is not tumor related
Presence of any non-healing wound, fracture, or ulcer within 28 days prior to the first dose of study drug.
Other clinically significant disorders such as:\r\n* Active infection requiring systemic treatment within 28 days before the first dose of study treatment\r\n* Serious non-healing wound/ulcer/bone fracture within 28 days before the first dose of study treatment
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Non-healing wound, ulcer, or bone fracture
Presence of any non-healing wound, fracture, or ulcer within 28 days prior to study registration.
Has a history of non-healing wounds or ulcers, or bone refractures within 3 months of fracture
Patients with serious non-healing wound, ulcer, or bone fracture
Serious or non-healing wound, ulcer, or bone fracture
Non-healing wound, ulcer, or bone fracture
Patients with serious non-healing wound, ulcer, or bone fracture, including history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 28 days; patients with granulating incisions healing by secondary intention with no evidence of fascial dehiscence or infection are eligible but require weekly wound examinations
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound or non-healing ulcer that is not tumor related
Serious non-healing wound, ulcer, or bone fracture
Ongoing serious, non-healing wound, ulcer, or bone fracture
Ongoing serious, non-healing wound, ulcer, or bone fracture
Serious or non-healing wound, skin ulcer, or bone fracture.
Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture
Participants who have non-healing wound, unhealed or incompletely healed fracture, or a compound (open) bone fracture at the time of enrollment
Serious non-healing wound, ulcer, or bone fracture
Serious non-healing wound, ulcer, or bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Patients with a serious, non-healing wound, ulcer, or bone fracture are not eligible for participation
Non-healing wound, bone fracture or skin ulcer
Presence of a non-healing wound, non-healing ulcer, or bone fracture
No history of serious (i.e., requiring active medical therapy with medication or medical device under the supervision of a physician) non-healing wound, ulcer, trauma, or bone fracture within 28 days prior to study entry
Non-healing wound, ulcer or fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Serious or non-healing wound, ulcer or bone fracture
History of a non-healing wound, ulcer, or bone fracture within 90 days (3 months) prior to registration
Non-healing wound, ulcer (including gastrointestinal), or fracture
Serious or non-healing wound, ulcer or bone fracture; if patient develops a serious or non-healing wound, ulcer or bone fracture after enrollment, but prior to study drug initiation, patient is not eligible to begin protocol therapy
Non-healing wound, ulcer or bone fracture
No serious non-healing wound, ulcer or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
Serious or non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
History of serious or non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
Patients with a history of non-healing wounds or ulcers, or bone refractures within 3 months of fracture
Non-healing wound, ulcer, or bone fracture
Patients with documented chronic non-healing wound, ulcer or bone fracture
Subject has a serious, non-healing wound, ulcer, or bone fracture
Serious or non-healing active wound, ulcer, or bone fracture
Serious non-healing wound, active ulcer, or unhealed bone fracture.
Patients with serious non-healing wound, ulcer, or untreated bone fracture. This includes a history of abdominal fistula or gastrointestinal perforation within 6 months prior to Day 1. Patients with granulating incisions healing by secondary intention with no evidence of fascial dehiscence or infection are eligible but require weekly wound examinations until closure.
Serious or non-healing wound, ulcer or bone fracture
Serious, non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture
Non-healing wound, ulcer, or bone fracture.
Serious non-healing wound or ulcer on scalp
Severe acute infection; serious non-healing wound or ulcer on scalp
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Presence of a non-healing wound, non-healing skin ulcer, or bone fracture
Presence of a non-healing wound or bone fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture
Patients with a serious non-healing wound ulcer, or bone fracture, or major surgical procedure within 21 days prior to starting treatment
Non-healing wound, ulcer, or bone fracture.
Have a serious or nonhealing wound, peptic ulcer, or bone fracture within 28 days prior to receiving study drugs.
Serious, non-healing wound, ulcer, or bone fracture.
Uncontrolled diabetes, active liver disease, poorly controlled chronic obstructive pulmonary disease, serious or non-healing wound, ulcer, or fracture;
Serious, non-healing wound, ulcer, or bone fracture
Severe, nonhealing or open wound, active ulcer, or untreated bone fracture
Serious and non-healing wound, active ulcer, or untreated bone fracture.
Non-healing wound, ulcer, or bone fracture
Patients must not have a non-healing wound or fracture
Presence of any non-healing wound, fracture, or ulcer
Non-healing wound, skin ulcer, or bone fracture
Serious or non-healing wound, active ulcer, or untreated bone fracture
Serious, non-healing wound, skin ulcer (of any grade), or bone fracture.
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Serious, non-healing wound, ulcer, or bone fracture
Serious or non-healing active wound, ulcer, or bone fracture
Ongoing serious non-healing wound, ulcer, or bone fracture
Non-healing wound, ulcer (including gastrointestinal), or fracture
Serious, non-healing wound, active ulcer, or untreated bone fracture; bone fractures must be healed
Serious non-healing wound, ulcer, or bone fracture
Serious non-healing wound, ulcer, or active bone fracture;
Serious or non-healing wound, ulcer, or bone fracture
Has had a serious nonhealing wound, ulcer, or bone fracture within 4 weeks prior to randomization
Serious nonhealing wound, ulcer, or bone fracture within 28 days prior to randomization
Patients with serious non-healing wound, ulcer or bone fracture; this includes history of abdominal fistula or intra-abdominal abscess within 6 months; patients with granulating incisions healing by secondary intention with no evidence of fascial dehiscence or infection are eligible but require weekly wound examinations
Serious non-healing wound, ulcer, or bone fracture
A serious, non-healing wound, ulcer, or bone fracture
Serious, non-healed wound, ulcer, or bone fracture
No history of serious non-healing wound, ulcer, or bone fractures
Serious, non-healing or dehiscing wound or active ulcer
Any serious or non-healing wound, ulcer, or bone fracture
Serious, non-healing wound, active ulcer, or unhealed bone fracture
Presence of a non-healing wound, non-healing ulcer, or bone fracture
Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture
Patients with serious, non-healing wound, ulcer or bone fracture (other than pathologic fracture)
Serious, non-healing or dehiscing wound or active ulcer
History of recent fracture (within 3 months of recruitment), complicated non-healing fracture, hip arthroplasty, knee arthroplasty
Patient must not have a serious or non-healing wound, ulcer, or bone fracture