The use of immunosuppressive medication within 28 days prior to the first dose of nivolumab; the following are exceptions to this criterion:\r\n* Intranasal, topical, inhaled corticosteroids or local steroid injections (e.g. intra-articular injection)\r\n* Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g. CT scan premedication)
Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab and tremelimumab; the following are exceptions to this criterion:\r\n* Intranasal, inhaled, and topical steroids\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (eg, computed tomography [CT] scan premedication)
EXCLUSION - DURVALUMAB DRUG-SPECIFIC: Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab, with the exceptions of intranasal and inhaled corticosteroids or systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid. The following are exceptions to this criterion:\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab or tremelimumab. The following are exceptions to this criterion:\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication).
Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab or tremelimumab; the following are exceptions to this criterion:\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent\r\n* Steroids as premedication for hypersensitivity reactions (eg, computed tomography [CT] scan premedication)
Current use of immunosuppressive medication, except for the following:\r\n* Intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection)\r\n* Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
Current use of immunosuppressive medication, except for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; c. steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
Current use of immunosuppressive medication, EXCEPT for the following:\r\n* Topical, ocular, intra-articular, intranasal, and inhaled corticosteroids.\r\n* Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone equivalent.\r\n* Steroids as premedication for hypersensitivity reactions
Active autoimmune disease that might deteriorate when receiving an immunostimulatory agent: * Subjects with diabetes type I, vitiligo, psoriasis, hypo- or hyperthyroid disease not requiring immunosuppressive treatment are eligible \r\n* Current use of immunosuppressive medication, EXCEPT for the following: \r\n** Intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); \r\n** Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; \r\n** Steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication).
Current use of immunosuppressive medication, except for the following: \r\n* Intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection)\r\n* Systemic corticosteroids at physiologic doses ? 10 mg/day of prednisone or equivalent \r\n* Steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)
Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab or tremelimumab; the following are exceptions to this criterion:\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra-articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent\r\n* Steroids as premedication for hypersensitivity reactions (eg, computed tomography [CT] scan premedication)
Current use of immunosuppressive medication, EXCEPT for the following:\r\n* Intranasal, inhaled, topical steroids, or local steroid injection (e.g. intra-articular injection)\r\n* Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g. computed tomography [CT] scan premedication)
Current or prior use of immunosuppressive medication(s) within 14 days before study treatment is NOT permitted; the following are EXCEPTIONS to this criterion and are allowed\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)
Current use of immunosuppressive medication, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; c. steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication).
Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab or tremelimumab; the following are exceptions to this criterion:\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (e.g. intra articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed <<10 mg/day>> of prednisone or its equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g. computed tomography [CT] scan premedication)\r\n* Receipt of live attenuated vaccine within 30 days prior to the first dose of IP; Note: patients, if enrolled, should not receive live vaccine whilst receiving IP and up to 30 days after the last dose of IP
Current use of immunosuppressive medication, except for the following: \r\n* Intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection) \r\n* Systemic corticosteroids at physiologic doses ? 10 mg/day of prednisone or equivalent \r\n* Steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)
Current usage of immunosuppressant medication except for a) intranasal, inhaled, and topical corticosteroids and b) systemic corticosteroids equivalent to =< 10 mg/day of prednisone, c) steroids as premedication for hypersensitivity reactions (e.g. computed tomography [CT] scan premedication)
Current use of immunosuppressive medication, EXCEPT for the following:\r\n* Intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection)\r\n* Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
Current use of immunosuppressive medication, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; c. steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)
Current use of immunosuppressive medication, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (eg, intra-articular injection); b. systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; c. steroids as premedication for hypersensitivity reactions (eg, computed tomography [CT] scan premedication)
Subjects with diagnosis of immunodeficiency or who are receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment; the following are exceptions to this exclusion criteria: intranasal, inhaled, topical steroids, or local steroids injections (e.g. intra-articular injection); systemic corticosteroids at physiologic dose not to exceed 10 mg/day of prednisone or equivalent; steroids as premedication for hypersensitivity reactions (eg, computed tomography [CT] scan premedication)
Current or prior use of immunosuppressive medication within 14 days prior to the first dose of MEDI4736 or tremelimumab; the following are exceptions to this criterion:\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra-articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (eg, computed tomography [CT] scan premedication)
Current or prior use of immunosuppressive medication within 14 days before the first dose of investigational product (IP). The following are exceptions to this criterion: • Intranasal, inhaled, topical steroids, or local steroid injections (eg, intra articular injection) • Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent • Steroids as premedication for hypersensitivity reactions (eg, CT scan premedication).
Steroids as premedication for hypersensitivity reactions are permitted;
Subject is currently using or has used immunosuppressive medication within 14 days prior to the first dose of study treatment; the following are exceptions:\r\n* Intranasal, topical, inhaled, or local steroid injections (e.g., intra-articular injection)\r\n* Chronic systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reaction (e.g., infusion-related reactions, computed tomography [CT] scan premedication)
Current or prior use of systemic immunosuppressive medication within 28 days before the first dose of durvalumab + trabectedin, with the exception of systemic corticosteroids at physiological doses, which are not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid; the following are exceptions to this criterion:\r\n* Steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)
Steroids as premedication for hypersensitivity reactions (eg, computed tomography (CT) scan premedication);
Steroids as premedication for hypersensitivity reactions (eg, computed tomography [CT] scan premedication)
Use of immunosuppressive medications within 14 days before the first dose of study drug; the following are exceptions to this criterion: intranasal, inhaled, topical steroids, or local steroid injections (e.g. intra articular injection); systemic corticosteroids at physiological doses not to exceed 10mg/day of prednisone or its equivalent; steroids as premedication for hypersensitivity reactions (e.g. computed tomography [CT] scan premedication)
Current use of immunosuppressive medication, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; c. steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)
Current or prior use of immunosuppressive medication within 28 days before the first dose of durvalumab or tremelimumab; the following are exceptions to this criterion:\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
Current use of immunosuppressive medication, except for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; c. steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)
The use of immunosuppressive medication within 28 days prior to the first dose of durvalumab; the following are exceptions to this criterion:\r\n* Intranasal, topical, inhaled corticosteroids or local steroid injections (e.g. intraarticular injection)\r\n* Systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g. CT scan premedication)
Current or prior use of immunosuppressive medication within 7 days prior to enrollment with the following exceptions to this exclusion criterion: \r\n* Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra-articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab or tremelimumab; the following are exceptions to this criterion:\r\n* Intranasal, inhaled, topical steroids, or local steroid injections (e.g., intra articular injection)\r\n* Systemic corticosteroids at physiologic doses not to exceed <<10 mg/day>> of prednisone or its equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication)
Subject is currently using or has used immunosuppressive medication within 14 days prior to the study agent administration; the following are exceptions:\r\n* Intranasal, topical, inhaled, or local steroid injections (e.g., intra-articular injection)\r\n* Chronic systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or equivalent\r\n* Steroids as premedication for hypersensitivity reactions (e.g., infusion-related reactions, CT scan premedication)
Current use of immunosuppressive medication, EXCEPT for the following: a. intranasal, inhaled, topical steroids, or local steroid injection (e.g., intra-articular injection); b. systemic corticosteroids at physiologic doses =< 10 mg/day of prednisone or equivalent; c. steroids as premedication for hypersensitivity reactions (e.g., computed tomography [CT] scan premedication)
Patients with evidence of significant intracranial mass effect that requires > 4 mg of dexamethasone or bioequivalent per day for 5 consecutive days for management of symptoms at any time within 14 days of registration\r\n* Subjects on a standard high-dose steroid taper after craniotomy may receive a higher dose of corticosteroids within 14 days of registration, however must be at a dose =< 4 mg of dexamethasone or bioequivalent per day within 5 days prior to registration\r\n* Administration of steroids through a route known to result in a minimal systemic exposure (i.e., intranasal, intraocular, inhaled, topical, or local injection [e.g., intra-articular injection] corticosteroids [< 5% of body surface area]) are permitted\r\n* Subjects requiring hormone replacement with corticosteroids are eligible if the steroids are at doses =< 10 mg prednisone or bioequivalent per day\r\n* Steroids as premedication for hypersensitivity reactions (e.g., CT scan premedication) are allowed