PRE-REGISTRATION
PRE-REGISTRATION INCLUSION CRITERIA:
PRE-REGISTRATION INCLUSION CRITERIA
Registration must be completed =< 28 days of pre-registration
Pre-registration Eligibility Inclusion Criteria for the PIK3CA Mutant Cohort (closed 03/17/2016)
INCLUSION CRITERIA FOR PRE-REGISTRATION (PATIENTS WITH UNKNOWN HER2 MUTATION STATUS TO HAVE TUMOR TISSUE SCREENED):
PRE-REGISTRATION (OPTIONAL)
PRE-REGISTRATION INCLUSION CRITERIA:
PRE-REGISTRATION
PRE-REGISTRATION- INCLUSION CRITERIA
=< 28 days post pre-registration
FIRST REGISTRATION-INCLUSION:
SECONDARY REGISTRATION-INCLUSION:
PRE-REGISTRATION: Determined by study doctor that patient is unlikely to meet inclusion criteria after screening.
PRE-REGISTRATION:
PRE-REGISTRATION
PRE-REGISTRATION
PRE-REGISTRATION
c-KIT mutation status determination, local versus central assessments; at least one must apply:\r\n* Performed locally by polymerase chain reaction (PCR) and sequencing prior to pre-registration: The melanoma harbors at least one mutation in exon 9, 11, 13, 17 or 18 of the c-KIT gene; NOTE: registration to step 1 may occur upon confirmation of pre-registration Or\r\n* Performed locally by PCR and sequencing prior to pre-registration: if the melanoma harbors at least one mutation in the c-KIT gene but is not in an exon listed or is uncertain whether it is in one of these exons then eligibility to register to step 1 requires approval of a designated central reviewer; submit the cKIT report within 24 hours after pre-registration as indicated Or\r\n* If local assessment is not possible, metastatic (preferred) or primary tumor tissue should be on hand PRIOR to pre-registration and will be submitted to Massachusetts General Hospital – Pathology (MGH) within 5 working days following pre-registration as outlined; if submission of tissue will be submitted more than 5 working days after pre-registration, immediately notify MGH (Massachusetts General Hospital) to discuss the potential submission timeline\r\n* IMPORTANT: if the c-KIT status will be determined by MGH, strict attention is to be paid to the timeframes dictated; specifically, clinical assessments which must fall within 4 weeks of registration to treatment (step 1) may be performed or repeated during pre-registration to fall within the required timeframe
PRE-REGISTRATION INCLUSION CRITERIA: Scheduled for a transurethral resection of bladder tumor (TURBT)
PRE-REGISTRATION INCLUSION CRITERIA: Be a candidate for radical cystectomy
PRE-REGISTRATION INCLUSION CRITERIA: Willing to submit tissue for required correlative research
PRE-REGISTRATION INCLUSION CRITERIA
PRE-REGISTRATION-INCLUSION CRITERIA
PRE-REGISTRATION INCLUSION
REGISTRATION INCLUSION
PRE-REGISTRATION INCLUSION:
REGISTRATION INCLUSION:
PRE-REGISTRATION INCLUSION CRITERIA
PRE-REGISTRATION INCLUSION CRITERIA
PRE-REGISTRATION INCLUSION CRITERIA
PRE-REGISTRATION INCLUSION CRITERIA