Inadequate organ or bone marrow function
Inadequate hematologic function as evidenced by any of the following:
Inadequate liver function as evidenced by any of the following:
Inadequate bone marrow function
Inadequate renal function as defined by serum creatinine > 3x normal for age
Inadequate performance status/organ function.
Inadequate performance status/organ function.
Participants with prior Hepatitis B or C infection with inadequate liver function
Impaired hepatic or renal function, inadequate bone marrow reserve or organ function, Cardiac dysfunction
Inadequate liver function at screening as demonstrated by the following:
Inadequate pulmonary function
Inadequate marrow function in cohort 1:
Inadequate marrow function in cohort 2:\r\n* These patients will not have marrow function criteria
Inadequate liver, renal function as defined below for both cohorts:
An inadequate tumor specimen as defined by the local pathologist
Unstable/inadequate cardiac function:
Inadequate washout from prior therapy
Evidence of inadequate renal function (creatinine > 2 g/dL)
Inadequate bone marrow or organ function
Inadequate performance status/ organ function
Inadequate organ function, evidenced by the following laboratory results:
Pregnancy or inadequate contraception.
have inadequate organ function per protocol
Inadequate lung function
Inadequate hepatic function
Inadequate renal function
Inadequate bone marrow function
Inadequate organ function per protocol-specified total bilirubin, AST and ALT, creatinine clearance and alkaline phosphatase.
Inadequate organ function including:
Unstable/inadequate cardiac function:
Inadequate organ function including:
Inadequate organ function including:
Inadequate hematologic function (unless due to underlying lymphoma)
Inadequate organ function
Inadequate hematologic, renal, and liver function (unless due to underlying lymphoma)
Inadequate renal or liver function
Inadequate hematological, liver, renal, cardiac function
Has a history or presence of inadequate liver, renal, hematopoietic and/or cardiac function parameters outside protocol-defined range
Inadequate hematologic function, renal function, and liver function
Subject has inadequate marrow, hepatic, and/or renal function at the Screening Visit defined as:
Inadequate hematologic or hepatic function
Inadequate liver, renal or bone marrow function within 2 weeks of first dose
Inadequate renal function
Inadequate renal function
Inadequate bone marrow, renal, or liver function
Inadequate bone marrow function or evidence of end-organ damage
Inadequate hematologic, renal or liver function
Inadequate organ function as described
Inadequate hematologic, renal or liver function
Inadequate bone marrow, renal, or hepatic function as defined above, or an active coagulopathy that precludes tissue biopsy
E 17. Inadequate organ and bone marrow function
Inadequate liver function at screening and Day 1 (before drug administration) as demonstrated by:
Abnormal/inadequate blood values, liver and kidney function
abnormal/inadequate blood values, liver, and kidney function
Inadequate cardiac function
Inadequate heart function
Inadequate lung function
Inadequate renal, hepatic or bone marrow function
Inadequate renal function (Blood creatinine > 1.5 times the institutional ULN)
Inadequate hematopoietic, liver, endocrine or renal function
Inadequate lung function
Inadequate heart function
Inadequate hematologic or biologic function as determined by the following laboratory tests:
Inadequate organ and bone marrow function as evidenced by:
Inadequate bone marrow or other organ function (excluding hepatic impairment per eligibility criteria).
An inadequate tumor specimen as defined by the central pathologist.
Inadequate organ function as defined on laboratory tests
Inadequate lung function
Inadequate hematologic, biochemical, and organ function
Subject's laboratory results indicate inadequate organ function
Adequate hematological function unless inadequate function is due to underlying disease
Inadequate hematologic, liver, or renal function
Inadequate hematological, biochemical or organ function
Inadequate kidney, liver, blood clotting function
Inadequate blood count
Inadequate hematologic function as evidenced by any of the following:
Inadequate liver function as evidenced by any of the following:
Inadequate housing arrangements
Inadequate hemostasis
Inadequate hepatic function
Inadequate renal function
Inadequate bone marrow function