Cluster 0: albumin dl serum mg days initiation treatment performed gm registration Cluster 1: step registration prior randomization days eligibility crossover criteria dl patients Cluster 2: zubrod performance status patients registration days prior step ps karnofsky Cluster 3: physical examination activity history registration compulsorily detained days prior exam Cluster 4: finding metabolic reasonable suspicion contraindicates examination render dysfunction physical giving Cluster 5: hemorrhage intracranial stroke months history enrollment prior hemoptysis study dose Cluster 6: months survival prior past expected enrollment study history treatment therapy Cluster 7: month prior therapy study investigational treatment patients enrollment hemoptysis use Cluster 8: bilirubin upper normal limit total uln institutional times gilberts syndrome Cluster 9: aminotransferase ast alt aspartate alanine uln upper normal limit times Cluster 10: limits normal institutional bilirubin total upper creatinine serum potassium uln Cluster 11: normal limit upper creatinine uln serum times institutional alt ast Cluster 12: creatinine uln serum times institutional renal days registration obtained prior Cluster 13: liver uln disease metastases chronic cirrhosis alt ast hepatitis patients Cluster 14: alkaline phosphatase uln limit normal upper liver alp times bone Cluster 15: wort st phenytoin carbamazepine phenobarbital cypa rifampin johns inducers rifabutin Cluster 16: lipase amylase uln serum pancreatitis radiologic normal clinical pancreatic evidence Cluster 17: infection requiring systemic active therapy antibiotics antibiotic intravenous treatment days Cluster 18: bacterial fungal viral infection active uncontrolled infections systemic requiring antibiotics Cluster 19: infections active uncontrolled requiring antibiotics systemic illnesses opportunistic patients medical Cluster 20: pulmonary obstructive disease chronic severe requiring copd antibiotics hospitalization history Cluster 21: malignancy active years history concurrent treatment second prior requiring patients Cluster 22: infection active uncontrolled patients ongoing antibiotics eligible presence evidence systemic Cluster 23: uncontrolled medical severe disease active infection conditions seizures concurrent disorder Cluster 24: consent informed procedures study specific provide written prior signed ability Cluster 25: signed informed consent written form dated patient guardian study document Cluster 26: samples research provide purposes correlative blood willing tissue mandatory willingness Cluster 27: willingness understand sign ability written document informed consent subjects subject Cluster 28: consent informed able sign understand willing written form document patient Cluster 29: consent informed written voluntary sign guidelines nature legal accordance patients Cluster 30: board review irb approved institutional consent informed sign understand written Cluster 31: altered prohibit understanding mental rendering dementia consent informed status psychiatric Cluster 32: provide consent informed written able willing trial assent ability patients Cluster 33: heart angina myocardial infarction unstable congestive failure cardiac months uncontrolled Cluster 34: rituximab containing prior therapy treatment regimen refractory months received chemotherapy Cluster 35: platinum based chemotherapy regimen disease progression therapy line prior resistant Cluster 36: hormone releasing lhrh luteinizing therapy agonist thyroid androgen orchiectomy gnrh Cluster 37: adjuvant chemotherapy neoadjuvant therapy prior setting months metastatic neo treatment Cluster 38: myocardial infarction months angina unstable history prior coronary study stroke Cluster 39: metastatic disease evidence patients distant prior chemotherapy therapy recurrent cancer Cluster 40: pregnancy lactation breastfeeding current test positive women testing time standards Cluster 41: childbearing potential pregnancy test negative female serum females urine prior Cluster 42: protein urine ratio mg hour serum light dl proteinuria chain Cluster 43: test pregnancy negative urine serum positive female hours confirmed study Cluster 44: bearing child potential pregnancy test women negative pregnant serum female Cluster 45: women pregnancy test childbearing negative potential serum days prior urine Cluster 46: hcg chorionic gonadotropin beta human test pregnancy negative women potential Cluster 47: cancer diagnosis lung ovarian small cell primary center patients non Cluster 48: carcinoma cell squamous small urothelial adenocarcinoma histologically clear histology renal Cluster 49: bleeding diathesis active history disorder disorders gastrointestinal known significant evidence Cluster 50: heparin low molecular weight warfarin anticoagulation therapeutic aspirin dose lmwh Cluster 51: coagulopathy bleeding diathesis evidence history anticoagulation significant therapeutic absence disorder Cluster 52: warfarin anticoagulation vitamin antagonists therapeutic use patients receiving concomitant requires Cluster 53: ecog performance status appendix patients score scale equal adequate patient Cluster 54: ps ecog performance eastern cooperative oncology group status score scale Cluster 55: eastern cooperative oncology group ecog performance status karnofsky score scale Cluster 56: score karnofsky lansky performance years age patients kps ambulatory wheelchair Cluster 57: karnofsky performance status kps scale score lansky patients greater ecog Cluster 58: cardiac significant disease arrhythmia function history impaired arrhythmias requiring uncontrolled Cluster 59: retinal rvo occlusion vein history evidence current retinopathy serous risk Cluster 60: significant clinically disease cardiac history uncontrolled pulmonary investigator active ecg Cluster 61: cardiovascular significant disease clinically uncontrolled history including evidence pulmonary condition Cluster 62: pleural ascites effusion effusions pericardial requiring paracentesis drainage clinically thoracentesis Cluster 63: feeding breast pregnant women females pregnancy female patients lactating planning Cluster 64: pregnant women excluded study patients planning currently female females patient Cluster 65: lactating pregnant women females female patients breastfeeding study excluded subject Cluster 66: nursing pregnant women female patients females excluded lactating study mothers Cluster 67: breastfeeding pregnant women females female patients excluded patient subject study Cluster 68: mother breastfeeding discontinued pregnant excluded women treated study agents potential Cluster 69: monoclonal antibody reaction hypersensitivity severe history antibodies reactions infusion mab Cluster 70: contraindication contrast mri hypersensitivity known drugs allergy concomitant including gadolinium Cluster 71: alcohol abuse drug history substance current known dependence active illicit Cluster 72: tuberculosis tb bacillus active known history previous clinical diagnosis latent Cluster 73: pembrolizumab excipients hypersensitivity severe known grade epacadostat substance active history Cluster 74: hamster chinese ovary hypersensitivity recombinant products antibodies known human cell Cluster 75: hypersensitivity known excipients components history component drugs study formulation excipient Cluster 76: allergy known hypersensitivity components history study excipients formulations drug formulation Cluster 77: immediate reaction hypersensitivity idiosyncrasy chemically delayed drugs related dmso excipients Cluster 78: products hypersensitivity blood known murine investigational tobacco containing study allergy Cluster 79: metformin taking hypersensitivity reason subjects insulin currently known patients doxycycline Cluster 80: allergic reactions reaction history anaphylactic severe hypersensitivity humanized proteins antibodies Cluster 81: ul platelet count lymphocyte neutrophils transfusion independent days obtained prior Cluster 82: platelet mm count days cells transfusion prior transfusions obtained independent Cluster 83: equal greater years age dl count platelets hemoglobin mm platelet Cluster 84: platelet count mcl days transfusion prior transfusions plt dl ml Cluster 85: tissue tumor biopsy archival available sample slides obtained fresh paraffin Cluster 86: tumor biopsy primary cm patients biopsies solid accessible size resection Cluster 87: lymph node nodes axillary sentinel cm biopsy dissection disease regional Cluster 88: inr normalized ratio international time uln prothrombin pt thromboplastin partial Cluster 89: aptt activated thromboplastin partial ptt anticoagulant intended anticoagulants time pt Cluster 90: time pt prothrombin thromboplastin ptt partial inr uln normalized ratio Cluster 91: hepatitis positive virus hcv antibody hbv antigen surface infection test Cluster 92: hla donor matched leukocyte antigen unrelated drb related typing human Cluster 93: hepatitis reactive qualitative hbsag rna detected hcv ribonucleic surface acid Cluster 94: therapies prior received number anti patients therapy cancer anticancer treatment Cluster 95: pd programmed anti death ligand cell lymphocyte ctla antibody cytotoxic Cluster 96: concurrent therapy investigational agents chemotherapy cancer treatment use immunotherapy anti Cluster 97: chemotherapy prior received cytotoxic patients regimen treatment cancer regimens systemic Cluster 98: therapy prior anti chemotherapy systemic cancer hormonal treatment patients radiation Cluster 99: radiation therapy prior weeks chemotherapy treatment patients study received palliative Cluster 100: pelvic radiation prior radiotherapy irradiation previous abdominal therapy history patients Cluster 101: pd inhibitor ctla prior anti treatment therapy including durvalumab previous Cluster 102: prostate cancer adenocarcinoma prior biopsy therapy diagnosis treatment prostatectomy chemotherapy Cluster 103: neck head radiation squamous carcinoma cancer cell prior therapy cavity Cluster 104: anti pd ctla antibody prior therapy received checkpoint targeting agent Cluster 105: bowel gastrointestinal malabsorption resection vomiting absorption nausea small significantly disease Cluster 106: absorption gastrointestinal gi interfere disease alter oral malabsorption significantly disorders Cluster 107: abdominal perforation fistula gastrointestinal abscess intra history months obstruction gi Cluster 108: metastasis brain leptomeningeal known distant patients symptomatic suspected cns evidence Cluster 109: brain metastases known patients treated stable trial excluded clinical evidence Cluster 110: disease progression progressive patients evidence leptomeningeal therapy refractory treatment prior Cluster 111: nervous central cns metastases active known untreated disease meningitis lymphoma Cluster 112: cord spinal compression brain metastases leptomeningeal untreated symptomatic stable disease Cluster 113: cns metastases nervous central patients disease stable symptomatic treated brain Cluster 114: leukemia aml promyelocytic acute apl mds myeloid diagnosis myelodysplastic patients Cluster 115: risk high intermediate ipss mds prognostic scoring international patients disease Cluster 116: cr remission complete induction response aml leukemia pr patients relapse Cluster 117: blasts marrow bone leukemia aml blood mds peripheral refractory patients Cluster 118: illness compliance social requirements psychiatric intercurrent situations uncontrolled limit study Cluster 119: compliance psychological safety condition protocol study conditions psychiatric medical procedures Cluster 120: staff medical regimens conduct history noncompliance compliance study planning non Cluster 121: trial confound best abnormality results interfere participate laboratory duration current Cluster 122: illness medical psychiatric interfere condition prevent opinion abnormality potentially likely Cluster 123: illness pectoris social situations intercurrent arrhythmia uncontrolled compliance congestive limited Cluster 124: inappropriate make judgment study investigator severe interfere patient entry increase Cluster 125: interfere results study interpretation condition medical investigator participation opinion evaluation Cluster 126: cooperation substance abuse disorders interfere psychiatric requirements trial known study Cluster 127: opinion condition investigator medical study subject compromise patient participation safety Cluster 128: fraction ejection left ventricular lvef cardiac echocardiogram shortening lower normal Cluster 129: muga fraction echocardiogram acquisition ejection scan gated left ventricular lvef Cluster 130: ventricular heart arrhythmias fibrillation uncontrolled history myocardial block infarction failure Cluster 131: vaccines live attenuated influenza flu seasonal allowed inactivated intranasal vaccine Cluster 132: live vaccine days attenuated received prior dose study vaccination receipt Cluster 133: study pregnant inform suspect immediately agree contraception woman barrier duration Cluster 134: contraception dose study agree male method adequate abstinence use starting Cluster 135: access venous internet computer telephone central placement phone adequate sampling Cluster 136: bilirubin mg dl total syndrome gilberts gilbert serum direct unless Cluster 137: bilirubin uln total direct serum syndrome gilbert gilberts levels subjects Cluster 138: syndrome myelodysplastic history poems malabsorption organomegaly endocrinopathy polyneuropathy gilbert changes Cluster 139: testosterone ng dl castrate serum level nmol levels castration androgen Cluster 140: creatinine clearance min ml serum mg dl estimated uln crcl Cluster 141: mm longest measured measurable accurately lesion dimension diameter ct recorded Cluster 142: creatinine calculated clearance min ml serum measured uln crcl mg Cluster 143: mg dl creatinine serum years age maximum male calcium female Cluster 144: filtration glomerular rate min ml gfr creatinine estimated clearance renal Cluster 145: creatinine institutional clearance normal levels min ml uln upper calculated Cluster 146: creatinine gault cockcroft clearance min ml formula calculated using equation Cluster 147: bone marrow function adequate involvement cells blood biopsy patients prior Cluster 148: organ function adequate marrow defined hematologic end laboratory bone days Cluster 149: function adequate liver renal marrow bone kidney defined hematological inadequate Cluster 150: pugh child class score hepatic impairment cirrhosis liver severe classification Cluster 151: hepatic function adequate renal marrow bone defined hematological coagulation cardiac Cluster 152: hematologic function adequate renal hepatic inadequate coagulation liver defined toxicity Cluster 153: hiv positive known immunodeficiency virus human infection patients cd aids Cluster 154: hepatitis virus immunodeficiency hiv human infection known active hcv hbv Cluster 155: immunodeficiency hiv virus human known positive infection history antibodies acquired Cluster 156: hepatitis active infection known chronic hiv history positive viral patients Cluster 157: history primary immunodeficiency disease prior known hypertensive pancreatitis leptomeningeal patients Cluster 158: antiretroviral combination hiv immunodeficiency positive ineligible virus human therapy patients Cluster 159: qtc interval qt msec corrected prolongation ecg electrocardiogram prolonged milliseconds Cluster 160: qt long syndrome congenital history family qtc interval msec corrected Cluster 161: msec qtcf interval fridericia qt formula corrected ecg screening correction Cluster 162: ms qt interval corrected qtc qtcf fridericia mean correction ecg Cluster 163: grade toxicity alopecia toxicities prior therapy related recovered resolved previous Cluster 164: ctcae grade nci neuropathy hemorrhage version event bleeding diarrhea alopecia Cluster 165: common terminology adverse ctcae events grade criteria version institute national Cluster 166: neuropathy grade peripheral sensory pain motor greater existing higher patients Cluster 167: measurable disease evaluable lesion patients non defined cm lesions criteria Cluster 168: recist measurable disease version criteria defined according lesion evaluable based Cluster 169: response criteria recist solid evaluation tumors measurable disease version evaluable Cluster 170: english read speak speaking able understand write spanish ability language Cluster 171: swallow capsules tablets able unable patients inability intact pills ability Cluster 172: oral medications able medication inability ability patients absorption gastrointestinal tolerate Cluster 173: use medications prohibited medication drugs taking current study prior concomitant Cluster 174: immunosuppressive systemic corticosteroids medications therapy treatment chronic use medication agents Cluster 175: swallow oral retain able medication ability pills medications orally bowels Cluster 176: inability comply procedures unwillingness follow protocol study swallow requirements pills Cluster 177: expecting conceive trial projected screening children father visit breastfeeding duration Cluster 178: unable unwilling protocol comply follow requirements study consent patients abide Cluster 179: return follow institution enrolling willing monitoring phase active mayo study Cluster 180: rems program revlimid registered mandatory comply willing requirements mitigation able Cluster 181: comply visits procedures willing able study scheduled follow protocol ability Cluster 182: requirements comply able study protocol adhere schedule visit monitoring safety Cluster 183: half lives shorter whichever investigational prior weeks days drug therapy Cluster 184: longer whichever half lives investigational drug days study prior treatment Cluster 185: males females years age older aged time consent old non Cluster 186: age years time patients consent donor men old lansky women Cluster 187: years older age male female aged patients subjects time consent Cluster 188: granulocyte colony stimulating csf factor count mm absolute factors macrophage Cluster 189: neutrophil absolute count anc mm cells days registration prior support Cluster 190: mcl neutrophil absolute count anc days initiation performed treatment registration Cluster 191: ul neutrophil absolute count anc cells days peripheral registration prior Cluster 192: breast cancer invasive diagnosis prior patients inflammatory metastatic carcinoma dcis Cluster 193: therapy steroid immunosuppressive form systemic receiving immunodeficiency diagnosis dose days Cluster 194: sarcoma soft tissue ewing oncogene homolog tumor diagnosis confirmed rhabdomyosarcoma Cluster 195: glioma world organization grade health glioblastoma diagnosis histologically confirmed iv Cluster 196: hcc hepatocellular diagnosis systemic carcinoma sorafenib prior fibrolamellar confirmed liver Cluster 197: patient study subjects prior diagnosis participants subject clinical known blood Cluster 198: phase ii patients aim prior expansion cohort portion study treatment Cluster 199: inclusion criteria apply meet registration cohort patients additional specific protocol Cluster 200: following criteria meet patients treatment disease prior therapy defined progression Cluster 201: psa ng ml prostate rising progression value specific antigen prostatectomy Cluster 202: exclusion criteria registration apply cohort treatment specific patients tnbc pre Cluster 203: eligibility criteria medi phase cohort ii study cancer meet registration Cluster 204: cancer cell basal squamous adequately skin treated years situ malignancy Cluster 205: carcinoma cell skin basal squamous situ malignancy years cervix treated Cluster 206: diagnosed newly cancer malignancy patients years previously disease nonmelanoma residual Cluster 207: recovered therapy prior grade note molecule complications targeted administered adequately Cluster 208: cancer skin non melanoma malignancy situ years carcinoma cervix invasive Cluster 209: treated situ cancer adequately carcinoma curatively years curative intent malignancy Cluster 210: bmi mass index body kg obese overweight greater patients weight Cluster 211: weight loss months hearing lbs body past pounds unintentional program Cluster 212: kg body weight area surface bsa cells cd weigh patients Cluster 213: hodgkin lymphoma non nhl cell refractory relapsed classical autologous confirmed Cluster 214: myeloma multiple diagnosis relapsed refractory imwg therapy criteria working prior Cluster 215: lymphoma cell large follicular diffuse dlbcl mantle zone refractory marginal Cluster 216: expectancy life weeks greater patients estimated years equal investigator year Cluster 217: capacity forced predicted dlco carbon monoxide fev expiratory volume diffusing Cluster 218: expectancy life months greater estimated investigator opinion patients anticipated predicted Cluster 219: women contraception men childbearing potential use adequate unwilling pregnant study Cluster 220: contraceptive use potential effective reproductive method study methods men agreed Cluster 221: contraception methods intrauterine barrier device method use condom potential effective Cluster 222: surgically childbearing sterile potential abstain heterosexual activity sterilized study subjects Cluster 223: contraception use effective agree potential study childbearing male method female Cluster 224: fcbp agree contact sexual vasectomy condom latex successful potential lenalidomide Cluster 225: birth control potential effective use study method agree childbearing women Cluster 226: bilateral hysterectomy oophorectomy potential consecutive postmenopausal months childbearing tubal undergone Cluster 227: surgery prior patients weeks days radiation patient major treatment planned Cluster 228: healing wound fracture ulcer non bone presence major days active Cluster 229: traumatic injury major procedure significant surgical open biopsy days study Cluster 230: surgical procedure resection major prior days study weeks biopsy patients Cluster 231: corticosteroids inhaled topical steroids systemic prednisone immunosuppressive mg doses daily Cluster 232: autoimmune disease active history systemic past requiring suspected vitiligo immunosuppressive Cluster 233: autoimmune requiring psoriasis vitiligo diabetes recur hypothyroidism trigger type mellitus Cluster 234: disease inflammatory bowel colitis autoimmune ulcerative history arthritis systemic lupus Cluster 235: replacement systemic modifying thyroxine pituitary disease autoimmune insulin physiologic adrenal Cluster 236: ct pet tomography scan computed emission positron imaging mri disease Cluster 237: imaging resonance magnetic mri ct tomography computed scan disease brain Cluster 238: mri contrast undergo ct patients unable brain scan imaging contraindications Cluster 239: interstitial lung pneumonitis disease history evidence active infectious pulmonary ild Cluster 240: pneumonitis organizing fibrosis idiopathic pneumonia induced pulmonary history chest obliterans Cluster 241: pneumonitis infectious non history steroids required current evidence active known Cluster 242: composition compounds chemical similar attributed allergic reactions biologic history used Cluster 243: oxygen air room pulse oximetry saturation supplemental rest dyspnea pulmonary Cluster 244: severe infection immunodeficiency disease moderate pneumonia bacteremia hospitalization impairment complications Cluster 245: cypa strong inhibitors inducers cytochrome subfamily family polypeptide medications moderate Cluster 246: inhibitor prior treatment kinase therapy received parp mek cdk mtor Cluster 247: inhibitors prior kinase treatment tyrosine therapy mtor patients use pik Cluster 248: egfr alk mutation tki exon kinase mutations epidermal receptor treatment Cluster 249: investigational participated study device participating currently agent weeks therapy dose Cluster 250: received prior therapy patients treatment previously systemic days study weeks Cluster 251: patients eligible study excluded therapy prior treated treatment receiving receive Cluster 252: participant research study received treatment therapy prior disease receiving investigator Cluster 253: concurrently investigational receiving agents study patients therapy treatment agent using Cluster 254: drug study dose days administration prior weeks investigational therapy experimental Cluster 255: agents investigational receiving patients currently participants study anti eligible cancer Cluster 256: investigational agent days treatment study prior weeks received drug receiving Cluster 257: transaminase serum aminotransferase glutamic oxaloacetic sgot sgpt upper normal pyruvate Cluster 258: transaminase aminotransferase serum uln sgpt glutamic sgot alt oxaloacetic alanine Cluster 259: pressure mmhg blood systolic diastolic hypertension bp uncontrolled controlled antihypertensive Cluster 260: diabetes mellitus type uncontrolled controlled poorly ac insulin hbac glucose Cluster 261: seizure disorder history patients seizures medication brain requiring uncontrolled controlled Cluster 262: hypertension uncontrolled diabetes controlled despite pulmonary poorly history medical hypertensive Cluster 263: donor donors matched unrelated related blood cell infusion lymphocyte haploidentical Cluster 264: hg pressure mm blood systolic hypertension diastolic uncontrolled bp despite Cluster 265: vascular peripheral aortic disease aneurysm significant arterial repair thrombosis collagen Cluster 266: ischemic transient thrombosis attack cerebrovascular accident deep months embolism history Cluster 267: pacemaker metal implanted clips implants mri metallic devices pacemakers aneurysm Cluster 268: stage iv iii cancer disease ajcc melanoma ii breast nsclc Cluster 269: receptor er ihc negative estrogen positive progesterone hybridization fish breast Cluster 270: heart york association new failure class congestive nyha iv iii Cluster 271: platelets mm cells days anc prior transfusion registration obtained plt Cluster 272: platelets ul plt ml microliter cells days transfusion registration prior Cluster 273: mcl platelets days initiation performed treatment registration prior transfusion obtained Cluster 274: white wbc blood cell cells ul count mm mcl days Cluster 275: leukocytes mcl ul mm microliter days registration obtained ml phase Cluster 276: effects recovered prior toxic therapy acute fully grade chemotherapy radiotherapy Cluster 277: days prior registration study therapy treatment dose radiotherapy enrollment growth Cluster 278: weeks earlier administered adverse events recovered agents prior entering study Cluster 279: treatment prior previous study patients weeks therapy allowed dose anti Cluster 280: laboratory values parameters clinical following abnormalities study places clia range Cluster 281: major surgery weeks prior study days recovered drug dose effects Cluster 282: stable dose decreasing corticosteroids prior days patients weeks corticosteroid enrollment Cluster 283: weeks prior radiotherapy therapy chemotherapy study treatment dose nitrosoureas mitomycin Cluster 284: mg equivalent prednisone day dose corticosteroids daily corticosteroid systemic steroids Cluster 285: start treatment prior study weeks days trial investigational therapy radiotherapy Cluster 286: organ transplant history allogeneic solid allograft allografts corneal marrow bone Cluster 287: transplant stem cell allogeneic autologous prior hematopoietic months received patients Cluster 288: host graft gvhd versus disease transplant active stem allogeneic acute Cluster 289: transplantation allogeneic stem organ cell prior solid autologous hematopoietic marrow Cluster 290: histologically confirmed cytologically adenocarcinoma diagnosis prostate metastatic cancer nsclc cell Cluster 291: advanced locally metastatic unresectable disease histologically cancer confirmed solid recurrent Cluster 292: standard therapy care advanced solid metastatic refractory available histologically confirmed Cluster 293: hemoglobin dl transfusion days mmol prior transfusions registration erythropoietin transfused Cluster 294: hgb hemoglobin dl transfusion achieve intervention acceptable days note use Cluster 295: hemoglobin dl mmol gm hb mg greater level weeks phase Cluster 296: fasting glucose mg dl mmol triglycerides cholesterol serum plasma diabetes Cluster 297: leukemia acute plasma chronic cell lymphoblastic myeloid myelogenous lymphoma cml Cluster 298: involvement nervous central cns known active lymphoma leukemia patients malignancy Cluster 299: cll lymphocytic sll leukemia chronic iwcll diagnosis lymphoma transformation treatment