Cluster 453: evidence disease metastatic radiologic clinical definitive imaging patients time residual Cluster 1157: lipase uln serum times institutional registration pancreatitis capmatinib screened institutions Cluster 1753: lipase pancreatitis radiologic clinical evidence uln upper limit normal cabozantinib Cluster 2377: amylase pancreatitis lipase history increased pancreatic symptoms uln cholecystitis suggestive