Cluster 270: bowel inflammatory disease history active gastrointestinal diarrhea patients chronic ongoing Cluster 959: bowel disease celiac colitis diarrhea gastrointestinal inflammatory irritable chronic associated Cluster 2208: diarrhea grade chronic ctcae gastrointestinal persistent patients malabsorption etiology symptom Cluster 2242: fibrosis colitis pneumonitis inflammatory bowel pulmonary disease known history chronic