Cluster 417: impairment aged patient years known jeopardize mild hepatic renal moderate 
Cluster 501: renal insufficiency failure disease impairment kidney patients creatinine severe history 
Cluster 2183: severe hepatic impairment moderate disease cirrhosis cardiovascular renal existing pre 
Cluster 2337: hearing loss grade impairment sensorineural existing significant cisplatin patients clinically 
Cluster 2422: existing pre interstitial lung disease known cardiovascular carotid ild liver