Cluster 114: severe disease uncontrolled systemic infection active concurrent morbidity current septicemia Cluster 824: visceral disease crisis threatening metastases metastasis life rapid liver severe Cluster 1251: infection uncontrolled eligible patients subjects active stratum untreated study participation Cluster 1894: infection controlled antibiotics active eligible uncontrolled patients judged antimicrobial treatment Cluster 2008: threatening life infection uncontrolled active disease untreated patients antimicrobial severe Cluster 2255: spread threatening visceral term life short symptomatic complications risk advanced Cluster 2491: threatening life potentially autoimmune active disease second activated patients history