Cluster 498: allergy known history intolerance patients hypersensitivity reaction products egg gadolinium Cluster 676: hypersensitivity known history reaction patients ingredients products intolerance reactions comparator Cluster 1362: hypersensitivity perflutren known drug suspected products study acyclovir definity patients Cluster 1798: sensitivity known products components administered allergy derived dosing component ingredients Cluster 2401: murine products hypersensitivity containing protein reactions history allergy bovine known