Cluster 94: hemoglobin dl mg minimum patients enrollment phase weeks anemia arm Cluster 220: zubrod performance registration status days prior step documented patients study Cluster 468: step registration prior crossover days patients treatment mcl optional dl Cluster 1555: exclusion registration criteria randomization neratinib secondary intraperitoneal experiencing mucinous borderline Cluster 2349: step randomization prior registration ii days criteria dl enrollment hemoglobin