Cluster 34: inability comply protocol requirements assessments investigator follow available study willing Cluster 523: unable comply protocol requirements opinion investigator follow study patient consent Cluster 617: monitoring safety comply opinion requirements able investigator study eligible patients Cluster 1275: noncompliance regimens medical history haart unreliable protocol comply unable therapy Cluster 1282: unwilling follow unable requirements protocol consent instruction informed render instructions Cluster 1573: abide cooperate fully unwilling designee unable protocol investigator study subject Cluster 1924: addictive preclude psychiatric disorders meeting conditions requirements opinion patient investigator Cluster 2083: unwilling comply unable protocol patients requirements study procedures assessed investigator Cluster 2330: exclude opinion investigator subject presence following study enrollment patient patients Cluster 2466: compliant initiative investigator means protocol patient opinion proximity team study