Cluster 1414: uncontrolled arrhythmia significant clinically cardiac condition symptomatic arrhythmias medical confounding Cluster 1559: arrhythmias cardiac uncontrolled ventricular history symptomatic pressor significant disease known Cluster 1813: ventricular pacemaker cardiac arrhythmias contractions medication requiring premature supraventricular pericarditis Cluster 1978: uncontrolled hepatitis heart severe chronic congestive symptomatic disease quantifiable cardiac