Cluster 385: prostate cancer prior chemotherapy diagnosis therapy treatment resistant metastatic castration Cluster 1323: adjuvant neo chemotherapy therapy prior treatment months cancer received completion Cluster 1971: chemotherapy received prior patients radiation therapy cancer radiotherapy previous adjuvant Cluster 2149: fulvestrant treatment prior combination endocrine cohort therapy received study dose Cluster 2413: endocrine therapy breast cancer prior adjuvant chemotherapy metastatic treatment received Cluster 2470: remains received chemotherapy prior localized pelvic adjuvant years abdominal cancer