Cluster 309: dihydropyrimidine deficiency dehydrogenase dpd known fluorouracil fluoropyrimidine hypersensitivity capecitabine severe 
Cluster 722: gpd phosphate deficiency dehydrogenase glucose known history patients hereditary normal 
Cluster 1551: deficiency phosphate glucose dehydrogenase known history pd patients porphyria phosphatase 
Cluster 2437: oxaliplatin irinotecan fluoropyrimidine fluorouracil fu leucovorin bevacizumab capecitabine chemotherapy therapy