Cluster 457: thalidomide lenalidomide hypersensitivity known pomalidomide rash prior imids immunomodulatory applicable 
Cluster 491: proteasome inhibitor immunomodulatory imid prior therapy bortezomib lenalidomide refractory lines 
Cluster 1809: carfilzomib treatment prior bortezomib received therapy lenalidomide refractory dose days