Cluster 158: excipients hypersensitivity known drugs intolerance study allergies allergy ribociclib history Cluster 338: pembrolizumab excipients hypersensitivity severe known grade epacadostat substance active history Cluster 735: palbociclib ribociclib cdk possible hypersensitivity fulvestrant endocrine excipients abemaciclib previous Cluster 859: various analogues formulations excipients allergy medications agent known study allergic Cluster 2078: sirolimus temsirolimus everolimus hypersensitivity rapamycins known excipients analogs rapamycin intolerance Cluster 2274: classes excipients formulations hypersensitivity study drugs allergy suspected given drug Cluster 2416: allergies known drug intolerance subjects classes separate history vaccine adhesives Cluster 2454: azd structure similar inactive excipients chemical osimertinib drugs hypersensitivity class