Cluster 386: investigational device drug study days treatment participation currently agent trial Cluster 481: month participation study clinical product investigational involved preceding involving medication Cluster 623: trial trials included participation agents investigational duration clinical start days Cluster 1571: trial investigational participation clinical agent days drug prior treatment study Cluster 1646: participation study investigational clinical involving drug days weeks studies prior Cluster 1648: therapeutic weeks study participation drug treatment clinical molecule participated procedures Cluster 1652: investigation participated clinical dosing investigational month currently drug prior patients Cluster 2111: product participation clinical investigational study weeks days receipt months prior Cluster 2450: allergy suspected agent given trial known course sorafenib association investigational