Cluster 420: pulmonary hypertension embolism disease severe significant history fibrosis cardiac patients Cluster 654: heart clinically significant history hypertension qt ecg labile cardiac msec Cluster 1542: cardiomyopathy restrictive hypertrophic documented causes heart history cardiomegaly treatment significant Cluster 1976: qt cardiac heart ventricular coronary history screening block significant left Cluster 2120: abnormalities laboratory following cardiac significant ecg baseline history chemistry hematologic