Cluster 877: disorder bleeding unrelated significant congenital acquired cancer history cml presence Cluster 1262: disorder bleeding history bipolar psychiatric autoimmune known patients active anxiety Cluster 2054: thrombocytopenia heparin induced history platelets known platelet coagulopathy drug complications Cluster 2182: bleeding active risk high pathologic disorder carry major coagulopathy conditions Cluster 2314: coagulopathy bleeding disorder uncontrolled uncorrectable known existing history disorders patients Cluster 2431: disorders bleeding psychiatric history known patients neurological thrombotic major significant