Cluster 134: longer whichever lives half preceding investigational drug days dose study Cluster 216: investigational whichever half longer lives product agent prior days study Cluster 540: half lives agents investigational prior days treatment therapy study drug Cluster 1201: taken half investigational lives days shorter whichever agents minimum drug Cluster 1329: immunostimulatory whichever lives half agents systemic shorter treatment drug weeks Cluster 1397: shorter whichever half lives therapy weeks prior investigational chemotherapy treatment Cluster 1678: shorter half lives whichever days investigational dose drug study minimum Cluster 2231: whichever longer half lives drug investigational study days dose weeks Cluster 2326: antibody monoclonal lives half elapsed dose prior antibodies treatment days