Cluster 20: renal hepatic disease significant pulmonary cardiovascular endocrine investigator gastrointestinal metabolic 
Cluster 33: cardiac significant clinically disease history uncontrolled dysfunction pulmonary active months 
Cluster 361: cardiovascular significant including disease clinically uncontrolled pulmonary poorly active condition 
Cluster 1182: cardiovascular significant disease clinically uncontrolled history pulmonary active diseases months 
Cluster 1569: tolerance impair opinion investigator significant diseases treatment example trial inflammatory 
Cluster 1696: cardiac impaired function clinically significant diseases disease following including patients 
Cluster 1749: significant clinically disease history uncontrolled metabolic heart immunosuppression medical study 
Cluster 2232: morbidities active clinically disease significant compromise pulmonary uncontrolled participation condition 
Cluster 2260: uncontrolled concurrent significant compromise clinically medical severe participation neurological pulmonary 
Cluster 2278: cardiovascular history conditions disease evidence risk following uncontrolled unstable current 
Cluster 2304: significant disease interpretation affect diseases pulmonary uncontrolled concomitant results compliance