Cluster 246: pugh child score class liver function hepatic disease points ascites Cluster 1448: pugh cirrhosis child liver class score classification present patients worse Cluster 1532: pugh hepatic impairment child class severe moderate patients baseline liver Cluster 1833: pugh child impairment hepatic classification according currently clinically significant class Cluster 2296: childs cirrhosis pugh class score liver severe hepatic known disease