Cluster 78: reaction antibody monoclonal hypersensitivity severe history mab components infusion allergy Cluster 144: pembrolizumab nivolumab hypersensitivity prior dose treatment received therapy known mk Cluster 467: mannitol hypersensitivity boron bortezomib azacitidine known suspected allergy velcade history Cluster 525: talazoparib components hypersensitivity known capsule suspected bmn treatment previous prior Cluster 684: reaction allergic history prior hypersensitivity involved known severe protocol drug Cluster 851: component hypersensitivity known formulation allergy bevacizumab study reaction history drug Cluster 958: components allergy history drug study known hypersensitivity nivolumab treatment reaction Cluster 1597: fentanyl allergy history propofol opioids patches transdermal tolerant lidocaine midazolam Cluster 1685: formulation components allergy hypersensitivity identified previously study subject treatment known Cluster 2223: formulations allergy components hypersensitivity identified previously component study known cobimetinib