Cluster 269: line therapy prior chemotherapy received disease patients treatment systemic second Cluster 293: therapy prior systemic received chemotherapy patients treatment disease allowed radiation Cluster 613: therapy prior patients allowed radiation dose weeks days treatment chemotherapy Cluster 644: radiation therapy prior chemotherapy patients treatment days field gy allowed Cluster 1146: therapies prior number received cancer anti patients allowed systemic limit Cluster 1178: sorafenib hcc prior treatment systemic therapy received intolerance progression patients Cluster 2306: conventional therapy chemotherapy radiation curable weeks patients tumor disease treatment