Cluster 76: containing platinum regimen chemotherapy progression prior therapy cisplatin disease treatment Cluster 470: lenalidomide prior therapy treatment use cycles patients dexamethasone received refractory Cluster 558: induction chemotherapy aml therapy patients refractory intensive consolidation cr regimen Cluster 1143: grapefruit seville oranges juice study star containing fruits fruit products Cluster 1311: nivolumab predisposition hepatoxicity caution drugs used containing regimen treated hepatotoxicity Cluster 1810: irinotecan prior topotecan hypersensitivity topoisomerase regimen containing treatment hydrochloride patients Cluster 1815: rituximab containing prior therapy treatment months regimen refractory received dose