Patients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trial; previously treated brain metastases, neurologically stable, and no ongoing or anticipated need for steroid therapy are eligibleXx_NEWLINE_xXPatients with known brain metastases should be excluded from early clinical trialsXx_NEWLINE_xXPatients with known leptomeningeal or brain metastases or spinal cord compression should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXParticipants with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases are excludedXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trial; a scan to confirm the absence of brain metastasis is not requiredXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXParticipants with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trial except as those described belowXx_NEWLINE_xXPatients with known active or history of brain metastases should be excluded from this clinical trialXx_NEWLINE_xXPatients with known brain metastases should be excluded from this clinical trialXx_NEWLINE_xX