Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise, grade 2 dyspnea Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) REGORAFENIB EXCLUSION CRITERIA: Pleural effusion or ascites causing respiratory compromise (dyspnea grade 2 or higher) Pleural effusion or ascites that causes respiratory compromise (? NCI-CTCAE version 4.03 Grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (ie, >= grade 2 dyspnea) Pleural effusion or ascites that causes > grade 1 dyspnea Pleural effusion or ascites that causes respiratory compromise (? CTCAE Grade 2 dyspnea). Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (eg, >= grade 2 dyspnea) Active signs and symptoms of interstitial lung disease pleural effusion or ascites that causes respiratory compromise (>= grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (? NCI-CTCAE version 4.03 Grade 2 dyspnea). Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (? NCI CTCAE version 4.0 Grade 2 dyspnea). Pleural effusion or ascites that causes respiratory compromise (>= NCI-CTCAE version 4.0 grade 2 dyspnea); patients may undergo thoracentesis and paracentesis to improve symptoms prior to enrollment Pleural effusion or ascites that causes respiratory compromise Pleural effusion or ascites that causes respiratory compromise (>= grade 2 dyspnea) Pleural effusion or ascites that causes respiratory compromise (>= grade 2 dyspnea CTCAE)