Creatinine no greater than the institutional upper limits of normal Creatinine within 1.5 x the ULN institutional limits Creatinine within normal institutional limits Creatinine ? 1.5 x upper limits of normal Creatinine within normal laboratory limits Creatinine =< upper normal institutional limits PIK3CA WILD TYPE COHORT (closed 03/17/2016): Creatinine =< upper normal institutional limits ENDOCRINE RESISTANT COHORT: Creatinine =< upper normal institutional limits Free T4 within institutional normal limits. Creatinine within normal institutional limits Serum creatinine within normal institutional limits OR Creatinine within normal institutional limits Creatinine within institutional normal limits Serum creatinine ? 1.5 X age-adjusted upper limits of normal (ULN) Creatinine within normal institutional limits Creatinine within normal institutional limits OR Creatinine within 1.5 x normal institutional limits. Creatinine within 1.5 x upper limit of normal institutional limits Creatinine within 1.5 x normal institutional limits Serum creatinine within the institutional normal limits, OR if the creatinine is elevated Creatinine within normal institutional limits OR Serum creatinine < 1.5 x upper limits of normal (ULN) Serum creatinine =< 1.5 x normal institutional limits Creatinine within normal institutional limits, assessed within 14 days prior to registration OR PHASE II: Serum creatinine within normal institutional limits Creatinine within normal institutional limits Glucose within normal institutional limits Creatinine < 1.5 x institutional upper limits of normal (ULN) Creatinine within normal institutional limits OR according to Johns Hopkins MRI policy Creatinine =< 1.5 X upper limits of normal Creatinine within normal institutional limits OR Creatinine within normal institutional limits OR Creatinine within or below normal institutional limits Creatinine =< 1.5 X upper limits of normal (ULN) Creatinine < 2 times the upper limits of normal (ULN) Creatinine within normal institutional limits OR Serum creatinine < 2.0 x the upper limits of institutional normal (ULN) Serum creatinine less than 1.5 times the upper limits of normal within 7 days prior to starting treatment Creatinine within normal limits Creatinine within normal institutional limits Urinalysis within normal institutional limits Serum creatinine < 2.0 x the upper limits of institutional normal (ULN) Cardiac function within institutional normal limits on echocardiogram Creatinine within normal institutional limits OR Creatinine =< 1.5 x upper limits of normal Creatinine within normal institutional limits OR Creatinine within normal institutional limits OR Creatinine =< 2 x institutional upper limits of normal Regimens I and II: Creatinine =< 1.5 x institutional upper limit normal (ULN), CTCAE grade 1\r\n* Regimen III: Creatinine no greater than the institutional upper limits of normal Creatinine =< 1.5 x upper limits of normal (ULN) Creatinine =< normal institutional limits OR Creatinine =< 2 times the upper limits of normal (ULN) Serum creatinine within 3 times the upper limits of normal Renal insufficiency: anything over institutional normal limits for creatinine that is also clinically documented Within 14 days of registration: Creatinine within normal institutional limits OR Creatinine < 2 x institutional limits Creatinine within 1.5 x the upper limit of normal (ULN) institutional limits Creatinine =< 2 x upper limits of normal (ULN) Creatinine =< 2 times the upper limits of normal (ULN) Obtained within 2 weeks from study entry: Creatinine =< 1.5 X upper limits of normal Free thyroxine (T4) within normal limits Creatinine within normal institutional limits OR creatinine within normal institutional limits OR Creatinine < 1.5 x institutional upper limits of normal Creatinine =< 2 x normal institutional limits Troponin T or I within normal institutional limits Serum creatinine within normal limits within 90 days prior to registration creatinine within normal institutional limits OR Serum creatinine =< 1.5 X upper limits of normal or creatinine clearance > 60 mg/min for subjects with creatinine levels >= 1.5 X upper limits of normal Cardiac function within institutional normal limits on echocardiogram Serum creatinine within normal institutional limits Troponin I or T within normal limits Serum creatinine less than 1.5 times the upper limits of normal Serum creatinine (Cr) within normal limits (WNL) or Electrolytes within normal limits Coagulation: INR within normal limits, PTT within normal limits Serum creatinine within normal limits Creatinine up to 1.5 X normal institutional limits Creatinine within normal institutional limits OR Hemoglobin within institutional normal limits Platelet count within institutional normal limits Creatinine within normal institutional limits for age Creatinine =< 1.5 x upper limits of normal Creatinine within normal limits Creatinine =< institutional upper limits of normal (ULN) Creatinine =< the upper institutional limits Creatinine within normal institutional limits Serum creatinine < 1.5 x upper limits of normal, or Serum creatinine =< 2.0 x upper limits of normal, or Creatinine within normal institutional limits Normal renal function (defined as creatinine within normal institutional limits) Known chronic kidney disease with creatinine greater than normal institutional limits Within 30 days of eligibility confirmation: Creatinine not above the upper limit of normal institutional limits Renal insufficiency (i.e., serum creatinine outside of normal limits) Platelets within normal institutional limits Creatinine =< the upper institutional limits Creatinine within institutional normal limits Creatinine clearance within normal limits Creatinine within normal institutional limits Creatinine within normal institutional limits serum creatinine w/in normal limits or