No history of the following:\r\n* Active known or suspected autoimmune disease\r\n* Patients with human immunodeficiency virus (HIV) are eligible if the lymphocytes > 350 cluster of differentiation (CD)4+ cells and no detectable viral load\r\n* Symptomatic, untreated, or uncontrolled brain metastases present\r\n* Active autoimmune colitis \r\n* Autoimmune panhypopituitarism \r\n* Autoimmune adrenal insufficiency \r\n* Known active hepatitis B or C\r\n** Hepatitis B can be defined as:\r\n*** Hepatitis B surface antigen (HBsAg) > 6 months\r\n*** Serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) 20,000 IU/ml (105 copies/ml), lower values 2,000-20,000 IU/ml (104-105 copies/ml) are often seen in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B\r\n*** Persistent or intermittent elevation in alanine aminotransferase (ALT)/alanine aminotransferase (AST) levels\r\n*** Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation\r\n** Hepatitis C can be defined as:\r\n*** Hepatitis C antibody (Ab) positive\r\n*** Presence of hepatitis C virus (HCV) ribonucleic acid (RNA)\r\n* Known active pulmonary disease with hypoxia defined as:\r\n** Oxygen saturation < 85% on room air or\r\n** Oxygen saturation < 88% despite supplemental oxygen
No known active hepatitis B or C\r\n* Active hepatitis B can be defined as: \r\n** Hepatitis B virus surface antigen (HBsAg) detectable for > 6 months;\r\n** Serum hepatitis B virus (HBV) DNA 20,000 IU/ml (105 copies/ml); lower values 2,000-20,000 IU/ml (104-105 copies/ml) are often seen in hepatitis B virus e antigen (HBeAg)-negative chronic hepatitis B\r\n** Persistent or intermittent elevation in ALT/AST levels \r\n** Liver biopsy showing chronic hepatitis with moderate or severe necroinflammation\r\n* Active hepatitis C can be defined as: \r\n** Hepatitis C antibody (AB) positive AND \r\n** Presence of hepatitis C virus (HCV) RNA
No history of the following:\r\n* Child Pugh class B or C liver disease\r\n* “Chronic active” hepatitis defined as: \r\n** Hepatitis B surface antigen (HBsAg) > 6 months\r\n** Serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) 20,000 IU/ml (105 copies/ml), lower values 2,000-20,000 IU/ml (104-105 copies/ml) are often seen in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B\r\n** Persistent or intermittent elevation in alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels\r\n** Liver biopsy showing chronic hepatitis with moderate or severe necroin?ammation
Active hepatitis B, either active carrier (hepatitis B surface antigen positive [HBsAg +]) or viremic (hepatitis B virus [HBV] deoxyribonucleic acid [DNA] >= 10,000 copies/mL, or >= 2,000 IU/mL)
Active hepatitis B, either active carrier (hepatitis B surface antigen [HBsAg] +) or viremic (hepatitis B virus [HBV] deoxyribonucleic acid [DNA] >= 10,000 copies/mL, or >= 2,000 IU/mL)
Active hepatitis B, either active carrier (hepatitis B surface antigen positive [HBsAg +]) or viremic (hepatitis B virus [HBV] deoxyribonucleic acid [DNA] >=10,000 copies/mL, or >= 2,000 IU/mL)
Active hepatitis B, either active carrier (hepatitis B surface antigen positive [HBsAg +]) or viremic (hepatitis B virus [HBV] deoxyribonucleic acid [DNA] >= 10,000 copies/mL, or >= 2,000 IU/mL)
Active hepatitis B, either active carrier (hepatitis B virus surface antigen [HBsAg] +) or viremic (hepatitis B virus [HBV] deoxyribonucleic acid [DNA] >= 10,000 copies/mL, or >= 2,000 IU/mL)
Patients with active hepatitis B, either active carrier (hepatitis B surface antigen [HBsAg] +) or viremic (hepatitis b virus [HBV] deoxyribonucleic acid [DNA] >= 10,000 copies/mL, or >= 2,000 IU/mL)
Active hepatitis B, either active carrier (hepatitis B surface antigen [HBsAg] +) or viremic (hepatitis B virus [HBV] deoxyribonucleic acid [DNA] >= 10,000 copies/mL, or >= 2,000 IU/mL)
Active hepatitis B, either active carrier (hepatitis B surface antigen [HBsAg] +) or viremic (hepatitis B virus [HBV] deoxyribonucleic acid [DNA] >/= 10,000 copies/mL, or >= 2,000 IU/mL).
Patients with active hepatitis B, either active carrier (hepatitis B virus surface antigen [HBsAg] +) or viremic (hepatitis B virus [HBV] deoxyribonucleic acid [DNA] >= 10,000 copies/mL, or >= 2,000 IU/mL)
Hepatitis B virus deoxyribonucleic acid (DNA) levels >2,000 international units/mL.
No history of the following: \r\n* Active known or suspected autoimmune disease\r\n* Human immunodeficiency virus (HIV) with CD4+ count < 300 or detectable viral load; patients with HIV, undetectable viral load, and CD4+ count >= 300 are eligible\r\n* Known active hepatitis B or C\r\n** Hepatitis B can be defined as: \r\n*** Hepatitis B virus surface antigen (HBsAg) > 6 months\r\n*** Serum hepatitis B virus (HBV) deoxyribonucleic acid (DNA) 20,000 IU/ml (105 copies/ml), lower values 2,000-20,000 IU/ml (104-105 copies/ml) are often seen in hepatitis B virus e antigen (HBeAg)-negative chronic hepatitis B\r\n*** Persistent or intermittent elevation in alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels\r\n*** Liver biopsy showing chronic hepatitis with moderate or severe necroin?ammation\r\n** Hepatitis C can be defined as:\r\n*** Hepatitis C antibody (AB) positive\r\n*** Presence of hepatitis C virus (HCV) RNA\r\n* Known active pulmonary disease with hypoxia defined as oxygen saturation < 85% on room air
Active hepatitis B, either active carrier (hepatitis B surface antigen [HBsAg] +) or viremic (hepatitis B virus [HBV] DNA >= 10,000 copies/mL, or >= 2,000 IU/mL)